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Enzymatic Synthesis and Characterization of Hydrophilic Sugar Based Polyesters and Their Modification with Stearic Acid.
Polymers (Basel) 2016; 8(3)P

Abstract

Biodegradable and hydrophilic functional polyesters were synthesized enzymatically using xylitol or d-sorbitol together with divinyl adipate and lipase B from Candida antartica (CAL-B). The resulting polyesters had pendant OH-groups from their sugar units which were esterified to different degrees with stearic acid chloride. The structure and the degrees of polymerization of the resulting graft copolymers based on poly(xylitol adipate) and poly(d-sorbitol adipate) were characterized by ¹H NMR spectroscopy and SEC. DSC, WAXS and SAXS measurements indicated that a phase separation between polymer backbone and stearoyl side chains occurred in the graft copolymers, and, additionally, the side chains were able to crystallize which resulted in the formation of a lamellar morphology. Additionally, nanoparticles of the graft copolymers in an aqueous environment were studied by DLS and negative stain TEM.

Authors+Show Affiliations

Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany. muhammad.bilal@chemie.uni-halle.de.Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany. Marko.prehm@chemie.uni-halle.de.Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany. andrew.njau@student.uni-halle.de.Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany. muhammad.samiullah@chemie.uni-halle.de.Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany. annette.meister@chemie.uni-halle.de.Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany. joerg.kressler@chemie.uni-halle.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30979182

Citation

Bilal, Muhammad Humayun, et al. "Enzymatic Synthesis and Characterization of Hydrophilic Sugar Based Polyesters and Their Modification With Stearic Acid." Polymers, vol. 8, no. 3, 2016.
Bilal MH, Prehm M, Njau AE, et al. Enzymatic Synthesis and Characterization of Hydrophilic Sugar Based Polyesters and Their Modification with Stearic Acid. Polymers (Basel). 2016;8(3).
Bilal, M. H., Prehm, M., Njau, A. E., Samiullah, M. H., Meister, A., & Kressler, J. (2016). Enzymatic Synthesis and Characterization of Hydrophilic Sugar Based Polyesters and Their Modification with Stearic Acid. Polymers, 8(3), doi:10.3390/polym8030080.
Bilal MH, et al. Enzymatic Synthesis and Characterization of Hydrophilic Sugar Based Polyesters and Their Modification With Stearic Acid. Polymers (Basel). 2016 Mar 16;8(3) PubMed PMID: 30979182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enzymatic Synthesis and Characterization of Hydrophilic Sugar Based Polyesters and Their Modification with Stearic Acid. AU - Bilal,Muhammad Humayun, AU - Prehm,Marko, AU - Njau,Andrew Efraim, AU - Samiullah,Muhammad Haris, AU - Meister,Annette, AU - Kressler,Jörg, Y1 - 2016/03/16/ PY - 2016/02/18/received PY - 2016/03/04/revised PY - 2016/03/09/accepted PY - 2019/4/14/entrez PY - 2016/3/16/pubmed PY - 2016/3/16/medline KW - biodegradable polyesters KW - crystallization KW - enzymatic synthesis KW - graft copolymers KW - nanoparticles KW - stearic acid KW - sugars JF - Polymers JO - Polymers (Basel) VL - 8 IS - 3 N2 - Biodegradable and hydrophilic functional polyesters were synthesized enzymatically using xylitol or d-sorbitol together with divinyl adipate and lipase B from Candida antartica (CAL-B). The resulting polyesters had pendant OH-groups from their sugar units which were esterified to different degrees with stearic acid chloride. The structure and the degrees of polymerization of the resulting graft copolymers based on poly(xylitol adipate) and poly(d-sorbitol adipate) were characterized by ¹H NMR spectroscopy and SEC. DSC, WAXS and SAXS measurements indicated that a phase separation between polymer backbone and stearoyl side chains occurred in the graft copolymers, and, additionally, the side chains were able to crystallize which resulted in the formation of a lamellar morphology. Additionally, nanoparticles of the graft copolymers in an aqueous environment were studied by DLS and negative stain TEM. SN - 2073-4360 UR - https://www.unboundmedicine.com/medline/citation/30979182/Enzymatic_Synthesis_and_Characterization_of_Hydrophilic_Sugar_Based_Polyesters_and_Their_Modification_with_Stearic_Acid_ L2 - http://www.mdpi.com/resolver?pii=polym8030080 DB - PRIME DP - Unbound Medicine ER -