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Erythrocyte enzymes in polycythemia vera: a comparison to erythrocyte enzyme activities of patients with iron deficiency anemia.
Acta Haematol. 1986; 76(1):37-43.AH

Abstract

Fifteen cytoplasmic erythrocyte enzyme activities were determined in patients with polycythemia vera (PV), iron deficiency anemia (IDA), and a group of healthy volunteers. Among the PV patients, the erythrocyte enzyme activities were compared between 2 groups: patients treated solely with phlebotomy and patients treated with phlebotomy, Myleran (busulfan) and/or radioactive phosphorus 32P. Significant reduction in glutathione reductase activity was found in the PV group of patients. This activity was normalized by the addition of flavin adenine dinucleotide. In contrast to previous reports, no other enzyme activity was found to be significantly reduced. The activities of the enzymes known to be age-dependent were significantly elevated in all the groups tested except for phosphofructokinase and 3-phosphoglycerate mutase. The former was not elevated in any of the groups studied, while the latter was elevated only in the group of patients treated with Myleran and/or 32P. It was concluded that glutathione reductase (GR) deficiency is the only acquired enzyme deficiency in our group of PV patients and that radiation and chemotherapy did not induce further reduction in the activities of any of the enzymes tested. The possible involvement of GR deficiency in the etiology of the red cell life span shortening was discussed.

Authors

Avissar N
No affiliation info available
Farkash Y
No affiliation info available
Shaklai M
No affiliation info available

MeSH

Anemia, HypochromicBloodlettingBusulfanCombined Modality TherapyCytoplasmErythrocyte AgingErythrocytesFemaleFlavin-Adenine DinucleotideGlutathione ReductaseHumansMalePhosphorus RadioisotopesPolycythemia Vera

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3098025

Citation

Avissar, N, et al. "Erythrocyte Enzymes in Polycythemia Vera: a Comparison to Erythrocyte Enzyme Activities of Patients With Iron Deficiency Anemia." Acta Haematologica, vol. 76, no. 1, 1986, pp. 37-43.
Avissar N, Farkash Y, Shaklai M. Erythrocyte enzymes in polycythemia vera: a comparison to erythrocyte enzyme activities of patients with iron deficiency anemia. Acta Haematol. 1986;76(1):37-43.
Avissar, N., Farkash, Y., & Shaklai, M. (1986). Erythrocyte enzymes in polycythemia vera: a comparison to erythrocyte enzyme activities of patients with iron deficiency anemia. Acta Haematologica, 76(1), 37-43.
Avissar N, Farkash Y, Shaklai M. Erythrocyte Enzymes in Polycythemia Vera: a Comparison to Erythrocyte Enzyme Activities of Patients With Iron Deficiency Anemia. Acta Haematol. 1986;76(1):37-43. PubMed PMID: 3098025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte enzymes in polycythemia vera: a comparison to erythrocyte enzyme activities of patients with iron deficiency anemia. AU - Avissar,N, AU - Farkash,Y, AU - Shaklai,M, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 37 EP - 43 JF - Acta haematologica JO - Acta Haematol VL - 76 IS - 1 N2 - Fifteen cytoplasmic erythrocyte enzyme activities were determined in patients with polycythemia vera (PV), iron deficiency anemia (IDA), and a group of healthy volunteers. Among the PV patients, the erythrocyte enzyme activities were compared between 2 groups: patients treated solely with phlebotomy and patients treated with phlebotomy, Myleran (busulfan) and/or radioactive phosphorus 32P. Significant reduction in glutathione reductase activity was found in the PV group of patients. This activity was normalized by the addition of flavin adenine dinucleotide. In contrast to previous reports, no other enzyme activity was found to be significantly reduced. The activities of the enzymes known to be age-dependent were significantly elevated in all the groups tested except for phosphofructokinase and 3-phosphoglycerate mutase. The former was not elevated in any of the groups studied, while the latter was elevated only in the group of patients treated with Myleran and/or 32P. It was concluded that glutathione reductase (GR) deficiency is the only acquired enzyme deficiency in our group of PV patients and that radiation and chemotherapy did not induce further reduction in the activities of any of the enzymes tested. The possible involvement of GR deficiency in the etiology of the red cell life span shortening was discussed. SN - 0001-5792 UR - https://www.unboundmedicine.com/medline/citation/3098025/Erythrocyte_enzymes_in_polycythemia_vera:_a_comparison_to_erythrocyte_enzyme_activities_of_patients_with_iron_deficiency_anemia_ DB - PRIME DP - Unbound Medicine ER -