Tags

Type your tag names separated by a space and hit enter

Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris.
J Cosmet Dermatol. 2019 Dec; 18(6):1998-2003.JC

Abstract

BACKGROUND

Many dermatological diseases have a great impact on the psychological state of patients, like urticaria, psoriasis, atopic dermatitis, and acne vulgaris. Finding a "gold standard" biomarker for chronic stress in acne patients is challenging because of the complex etiology of the chronic stress and its variable manifestations.

AIMS

The aim of this study was to evaluate the correlation between serum levels of BDNF and the presence and severity of acne vulgaris and to assess the relationship of this biomarker to both the degree of psychological stress and the quality of patients' lives (QoL).

PATIENTS AND METHODS

Sixty patients with acne vulgaris were included, together with twenty apparently healthy, age-, and sex-matched individuals as a control group. Patients filled a Dermatology Life Quality Index (DLQI) questionnaire; both patients and controls filled a Hospital Anxiety and Depression scale (HADS) and perceived stress scale-10 (PSS) questionnaires. Serum levels of BDNF were measured for patients and controls using ELISA technique.

RESULTS

Patients with acne had significantly lower levels of BDNF and significantly higher HADS and PSS-10 questionnaires scores. A significant negative correlation was found between serum levels of BDNF and PSS questionnaire scores.

CONCLUSION

Patients with acne are at a high risk to develop chronic stress, anxiety, and depression. BDNF is a good predictor for assessment of chronic stress in such patients.

Authors+Show Affiliations

Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30980616

Citation

Mikhael, Nancy W., et al. "Serum Levels of Brain-derived Neurotrophic Factor in Patients With Acne Vulgaris." Journal of Cosmetic Dermatology, vol. 18, no. 6, 2019, pp. 1998-2003.
Mikhael NW, Hamed AM, Mansour AI, et al. Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris. J Cosmet Dermatol. 2019;18(6):1998-2003.
Mikhael, N. W., Hamed, A. M., Mansour, A. I., & Abdelrahman, E. S. (2019). Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris. Journal of Cosmetic Dermatology, 18(6), 1998-2003. https://doi.org/10.1111/jocd.12940
Mikhael NW, et al. Serum Levels of Brain-derived Neurotrophic Factor in Patients With Acne Vulgaris. J Cosmet Dermatol. 2019;18(6):1998-2003. PubMed PMID: 30980616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris. AU - Mikhael,Nancy W, AU - Hamed,Ahmed M, AU - Mansour,Amira I, AU - Abdelrahman,Eman S, Y1 - 2019/04/13/ PY - 2018/04/29/received PY - 2018/09/27/revised PY - 2019/03/08/accepted PY - 2019/4/14/pubmed PY - 2020/6/5/medline PY - 2019/4/14/entrez KW - acne KW - brain-derived neurotrophic factor KW - quality of life KW - stress SP - 1998 EP - 2003 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 18 IS - 6 N2 - BACKGROUND: Many dermatological diseases have a great impact on the psychological state of patients, like urticaria, psoriasis, atopic dermatitis, and acne vulgaris. Finding a "gold standard" biomarker for chronic stress in acne patients is challenging because of the complex etiology of the chronic stress and its variable manifestations. AIMS: The aim of this study was to evaluate the correlation between serum levels of BDNF and the presence and severity of acne vulgaris and to assess the relationship of this biomarker to both the degree of psychological stress and the quality of patients' lives (QoL). PATIENTS AND METHODS: Sixty patients with acne vulgaris were included, together with twenty apparently healthy, age-, and sex-matched individuals as a control group. Patients filled a Dermatology Life Quality Index (DLQI) questionnaire; both patients and controls filled a Hospital Anxiety and Depression scale (HADS) and perceived stress scale-10 (PSS) questionnaires. Serum levels of BDNF were measured for patients and controls using ELISA technique. RESULTS: Patients with acne had significantly lower levels of BDNF and significantly higher HADS and PSS-10 questionnaires scores. A significant negative correlation was found between serum levels of BDNF and PSS questionnaire scores. CONCLUSION: Patients with acne are at a high risk to develop chronic stress, anxiety, and depression. BDNF is a good predictor for assessment of chronic stress in such patients. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/30980616/Serum_levels_of_brain_derived_neurotrophic_factor_in_patients_with_acne_vulgaris_ L2 - https://doi.org/10.1111/jocd.12940 DB - PRIME DP - Unbound Medicine ER -