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Lower serum 25-hydroxyvitamin D is associated with colorectal and breast cancer, but not overall cancer risk: a 20-year cohort study.
Nutr Res. 2019 07; 67:100-107.NR

Abstract

Studies of the relationship between circulating 25-hydroxyvitamin D (25(OH)D) and cancer risk have been inconsistent. We hypothesized that serum 25(OH)D was associated with total non-skin cancer incidence and mortality, and/or specifically with colorectal, lung, breast or prostate cancer in an Australian cohort. Serum 25(OH)D was measured in 3818 participants (2166 females) in the 1994/1995 Busselton Health Survey aged 25 to 84 years at baseline. Cancer mortality and events over 20 years follow-up were determined by data linkage. The mean serum 25(OH)D concentration was 60.6 ± 18.0 nmol/L, with 28%, 54% and 18% of participants in the lower (<50 nmol/L), middle (50-75 nmol/L) and higher (≥75 nmol/L) vitamin D status groups, respectively. During follow-up (excluding the first 2 years), 212 participants died from non-skin cancer and 634, 110 and 44 participants had non-skin, colorectal and lung cancer events, respectively; 113 women had breast cancer and 122 men had prostate cancer events. For colorectal cancer, lower circulating 25(OH)D was associated with significantly higher risk compared with the middle group (covariate-adjusted HR 1.62, 95% CI 1.04, 2.53). For breast cancer, women with a higher 25(OH)D level had lower risk than women in the middle group (HR 0.38, 95% CI 0.16, 0.89) and the lower group (HR 0.37, 95% CI 0.15, 0.89). Serum 25(OH)D was not associated with overall cancer death or event, or with lung or prostate cancer. In this community-based cohort, lower 25(OH)D levels were associated with increased risk of colorectal and breast cancer, but not overall cancer risk.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhu K
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia; Medical School, University of Western Australia, Perth, WA 6009, Australia. Electronic address: kun.zhu@uwa.edu.au.
Knuiman M
School of Population and Global Health, University of Western Australia, Perth, WA 6009, Australia.
Divitini M
School of Population and Global Health, University of Western Australia, Perth, WA 6009, Australia.
Hung J
Medical School, University of Western Australia, Perth, WA 6009, Australia.
Lim EM
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia; Department of Clinical Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, WA 6009, Australia.
Cooke BR
Department of Clinical Biochemistry, PathWest Laboratory Medicine, Fiona Stanley Hospital, Perth, WA 6150, Australia.
Walsh JP
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia; Medical School, University of Western Australia, Perth, WA 6009, Australia.

MeSH

AdultAgedAged, 80 and overAustraliaBreast NeoplasmsCohort StudiesColorectal NeoplasmsComorbidityFemaleHumansMaleMiddle AgedNeoplasmsRisk FactorsVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30982554

Citation

Zhu, Kun, et al. "Lower Serum 25-hydroxyvitamin D Is Associated With Colorectal and Breast Cancer, but Not Overall Cancer Risk: a 20-year Cohort Study." Nutrition Research (New York, N.Y.), vol. 67, 2019, pp. 100-107.
Zhu K, Knuiman M, Divitini M, et al. Lower serum 25-hydroxyvitamin D is associated with colorectal and breast cancer, but not overall cancer risk: a 20-year cohort study. Nutr Res. 2019;67:100-107.
Zhu, K., Knuiman, M., Divitini, M., Hung, J., Lim, E. M., Cooke, B. R., & Walsh, J. P. (2019). Lower serum 25-hydroxyvitamin D is associated with colorectal and breast cancer, but not overall cancer risk: a 20-year cohort study. Nutrition Research (New York, N.Y.), 67, 100-107. https://doi.org/10.1016/j.nutres.2019.03.010
Zhu K, et al. Lower Serum 25-hydroxyvitamin D Is Associated With Colorectal and Breast Cancer, but Not Overall Cancer Risk: a 20-year Cohort Study. Nutr Res. 2019;67:100-107. PubMed PMID: 30982554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower serum 25-hydroxyvitamin D is associated with colorectal and breast cancer, but not overall cancer risk: a 20-year cohort study. AU - Zhu,Kun, AU - Knuiman,Matthew, AU - Divitini,Mark, AU - Hung,Joseph, AU - Lim,Ee Mun, AU - Cooke,Brian R, AU - Walsh,John P, Y1 - 2019/03/21/ PY - 2018/08/13/received PY - 2019/02/07/revised PY - 2019/03/15/accepted PY - 2019/4/16/pubmed PY - 2020/9/26/medline PY - 2019/4/16/entrez KW - 25-Hydroxyvitamin D KW - Breast cancer KW - Cancer death KW - Colorectal cancer KW - Follow-up study KW - Risk factors SP - 100 EP - 107 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 67 N2 - Studies of the relationship between circulating 25-hydroxyvitamin D (25(OH)D) and cancer risk have been inconsistent. We hypothesized that serum 25(OH)D was associated with total non-skin cancer incidence and mortality, and/or specifically with colorectal, lung, breast or prostate cancer in an Australian cohort. Serum 25(OH)D was measured in 3818 participants (2166 females) in the 1994/1995 Busselton Health Survey aged 25 to 84 years at baseline. Cancer mortality and events over 20 years follow-up were determined by data linkage. The mean serum 25(OH)D concentration was 60.6 ± 18.0 nmol/L, with 28%, 54% and 18% of participants in the lower (<50 nmol/L), middle (50-75 nmol/L) and higher (≥75 nmol/L) vitamin D status groups, respectively. During follow-up (excluding the first 2 years), 212 participants died from non-skin cancer and 634, 110 and 44 participants had non-skin, colorectal and lung cancer events, respectively; 113 women had breast cancer and 122 men had prostate cancer events. For colorectal cancer, lower circulating 25(OH)D was associated with significantly higher risk compared with the middle group (covariate-adjusted HR 1.62, 95% CI 1.04, 2.53). For breast cancer, women with a higher 25(OH)D level had lower risk than women in the middle group (HR 0.38, 95% CI 0.16, 0.89) and the lower group (HR 0.37, 95% CI 0.15, 0.89). Serum 25(OH)D was not associated with overall cancer death or event, or with lung or prostate cancer. In this community-based cohort, lower 25(OH)D levels were associated with increased risk of colorectal and breast cancer, but not overall cancer risk. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/30982554/Lower_serum_25_hydroxyvitamin_D_is_associated_with_colorectal_and_breast_cancer_but_not_overall_cancer_risk:_a_20_year_cohort_study_ DB - PRIME DP - Unbound Medicine ER -