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Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats.
Neural Plast 2019; 2019:2098083NP

Abstract

Although referred pain or hypersensitivity has been repeatedly reported in irritable bowel syndrome (IBS) patients and experimental colitis rodents, little is known about the neural mechanisms. Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. Herein, we sought to determine whether spinal LTP contributes to the referral hyperalgesia in colitis rats and particularly whether electroacupuncture (EA) is effective to alleviate somatic hyperalgesia via suppressing spinal LTP. Rats in the colitis group (induced by colonic infusion of 2,4,6-trinitrobenzenesulfonic acid, TNBS), instead of the control and vehicle groups, displayed evident focal inflammatory destruction of the distal colon accompanied not only with the sensitized visceromotor response (VMR) to noxious colorectal distension (CRD) but also with referral hindpaw hyperalgesia indicated by reduced mechanical and thermal withdrawal latencies. EA at Zusanli (ST36) and Shangjuxu (ST37) attenuated the severity of colonic inflammation, as well as the visceral hypersensitivity and referral hindpaw hyperalgesia in colitis rats. Intriguingly, the threshold of C-fiber-evoked field potentials (CFEFP) was significantly reduced and the spinal LTP was exaggerated in the colitis group, both of which were restored by EA treatment. Taken together, visceral hypersensitivity and referral hindpaw hyperalgesia coexist in TNBS-induced colitis rats, which might be attributed to the enhanced LTP of nociceptive synaptic transmission in the spinal dorsal horn. EA at ST36 and ST37 could relieve visceral hypersensitivity and, in particular, attenuate referral hindpaw hyperalgesia by suppressing the enhanced spinal LTP.

Authors+Show Affiliations

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China. Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30984253

Citation

Lv, Pei-Ran, et al. "Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia Via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats." Neural Plasticity, vol. 2019, 2019, p. 2098083.
Lv PR, Su YS, He W, et al. Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats. Neural Plast. 2019;2019:2098083.
Lv, P. R., Su, Y. S., He, W., Wang, X. Y., Shi, H., Zhang, X. N., ... Jing, X. H. (2019). Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats. Neural Plasticity, 2019, p. 2098083. doi:10.1155/2019/2098083.
Lv PR, et al. Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia Via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats. Neural Plast. 2019;2019:2098083. PubMed PMID: 30984253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats. AU - Lv,Pei-Ran, AU - Su,Yang-Shuai, AU - He,Wei, AU - Wang,Xiao-Yu, AU - Shi,Hong, AU - Zhang,Xiao-Ning, AU - Zhu,Bing, AU - Kan,Yu, AU - Chen,Li-Zhen, AU - Wu,Qiao-Feng, AU - Yu,Shu-Guang, AU - Jing,Xiang-Hong, Y1 - 2019/03/11/ PY - 2018/06/20/received PY - 2018/11/09/revised PY - 2019/02/03/accepted PY - 2019/4/16/entrez PY - 2019/4/16/pubmed PY - 2019/4/16/medline SP - 2098083 EP - 2098083 JF - Neural plasticity JO - Neural Plast. VL - 2019 N2 - Although referred pain or hypersensitivity has been repeatedly reported in irritable bowel syndrome (IBS) patients and experimental colitis rodents, little is known about the neural mechanisms. Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. Herein, we sought to determine whether spinal LTP contributes to the referral hyperalgesia in colitis rats and particularly whether electroacupuncture (EA) is effective to alleviate somatic hyperalgesia via suppressing spinal LTP. Rats in the colitis group (induced by colonic infusion of 2,4,6-trinitrobenzenesulfonic acid, TNBS), instead of the control and vehicle groups, displayed evident focal inflammatory destruction of the distal colon accompanied not only with the sensitized visceromotor response (VMR) to noxious colorectal distension (CRD) but also with referral hindpaw hyperalgesia indicated by reduced mechanical and thermal withdrawal latencies. EA at Zusanli (ST36) and Shangjuxu (ST37) attenuated the severity of colonic inflammation, as well as the visceral hypersensitivity and referral hindpaw hyperalgesia in colitis rats. Intriguingly, the threshold of C-fiber-evoked field potentials (CFEFP) was significantly reduced and the spinal LTP was exaggerated in the colitis group, both of which were restored by EA treatment. Taken together, visceral hypersensitivity and referral hindpaw hyperalgesia coexist in TNBS-induced colitis rats, which might be attributed to the enhanced LTP of nociceptive synaptic transmission in the spinal dorsal horn. EA at ST36 and ST37 could relieve visceral hypersensitivity and, in particular, attenuate referral hindpaw hyperalgesia by suppressing the enhanced spinal LTP. SN - 1687-5443 UR - https://www.unboundmedicine.com/medline/citation/30984253/Electroacupuncture_Alleviated_Referral_Hindpaw_Hyperalgesia_via_Suppressing_Spinal_Long-Term_Potentiation_(LTP)_in_TNBS-Induced_Colitis_Rats L2 - https://dx.doi.org/10.1155/2019/2098083 DB - PRIME DP - Unbound Medicine ER -