TY - JOUR T1 - The effect of transcutaneous vagus nerve stimulation on fear generalization and subsequent fear extinction. AU - Burger,A M, AU - Van Diest,I, AU - Van der Does,W, AU - Korbee,J N, AU - Waziri,N, AU - Brosschot,J F, AU - Verkuil,B, Y1 - 2019/04/12/ PY - 2018/3/5/received PY - 2019/4/6/revised PY - 2019/4/11/accepted PY - 2019/4/16/pubmed PY - 2019/12/25/medline PY - 2019/4/16/entrez SP - 192 EP - 201 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 161 N2 - Fear overgeneralization is thought to be one of the cardinal processes underlying anxiety disorders, and a determinant of the onset, maintenance and recurrence of these disorders. Animal studies have shown that stimulating the vagus nerve (VNS) affects neuronal pathways implicated in pattern separation and completion, suggesting it may reduce the generalization of a fear memory to novel situations. In a one-day study, 58 healthy students were subjected to a fear conditioning, fear generalization, and fear extinction paradigm. Participants were randomly assigned to receive either transcutaneous auricular VNS (tVNS; final N = 29) or sham stimulation (final N = 29) during the generalization and extinction phases. tVNS did not affect fear generalization, as reflected by US expectancy ratings and fear potentiated startle responses. However, participants who received tVNS reported lower US expectancy ratings to the CS+ during the extinction phase, possibly reflecting a stronger declarative extinction of fear. No effects of tVNS on fear potentiated startle responses during extinction were found. The pattern of findings regarding extinction of declarative fear suggest a facilitating effect of tVNS. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/30986531/The_effect_of_transcutaneous_vagus_nerve_stimulation_on_fear_generalization_and_subsequent_fear_extinction_ DB - PRIME DP - Unbound Medicine ER -