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[Core prescription excavation of launched Chinese patent medicines for treating different syndromes of angina pectoris].
Zhongguo Zhong Yao Za Zhi. 2019 Mar; 44(5):1041-1047.ZZ

Abstract

To analyze the medication features and regularity of prescriptions of traditional Chinese medicines in treating patients with coronary heart disease angina pectoris based on the launched Chinese patent medicines. In the article,we collected all of the launched Chinese patent medicines for treating coronary heart disease and angina pectoris from the Chinese patent medicine value assessment information database,and set up a medical record normalized database,then carried out the classification of syndromes. The medication features and prescription rules for angina pectoris were analyzed by frequency statistics and association rules(IBM SPSS Modeler 14. 1 Premiums software,Apriori algorithm). Finally,a total of 170 prescriptions were selected,and 197 Chinese herbs were included,involving to totally 11 syndrome types,in which blood stasis syndrome,Qi stagnation and blood stasis syndrome,Qi deficiency and blood stasis syndrome,Qi-Yin deficiency and blood stasis syndrome were the main syndrome types. The frequency of single-herb medicines for the four main syndrome types,the combination of commonly used medicines,and the core prescriptions were summarized. After comparing the core prescriptions of the four syndrome types,we could analyze the medication features and prescription rules. In conclusion,the therapeutic principle is blood-activating and stasis-dissolving,and consideration was also given to promoting Qi,invigorating Qi and resuscitation and invigorating Qi-Yin. The main medicines include Danshen(Salvia Miltiorrhizae Radix et Rhizoma) and Chuan-xiong(Chuanxiong Rhizoma). According to different types of syndromes,Chinese herbal medicines are added,such as Jiangxiang(Dalbergiae Odoriferae Lignum), Chishao(Paeoniaeradix Rubra), Sanqi(Notoginseng Radix et Rhizoma), Honghua(Carthami Flos),Bingpian(Borneolum Syntheticum),Renshen(Ginseng Radix et Rhizoma). Frequency statistics and association rules are combined to explore the medication features and core prescriptions,which provide ideas for the treatment of angina pectoris and the development of new drugs.

Authors+Show Affiliations

Institution of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.Institution of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.Institution of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.Institution of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.Institution of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.Institution of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.Institution of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

30989867

Citation

Wei, Peng-Lu, et al. "[Core Prescription Excavation of Launched Chinese Patent Medicines for Treating Different Syndromes of Angina Pectoris]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 44, no. 5, 2019, pp. 1041-1047.
Wei PL, Gu H, Guan S, et al. [Core prescription excavation of launched Chinese patent medicines for treating different syndromes of angina pectoris]. Zhongguo Zhong Yao Za Zhi. 2019;44(5):1041-1047.
Wei, P. L., Gu, H., Guan, S., Su, Y. Y., Liu, Q., Liu, J., & Wang, Z. (2019). [Core prescription excavation of launched Chinese patent medicines for treating different syndromes of angina pectoris]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 44(5), 1041-1047. https://doi.org/10.19540/j.cnki.cjcmm.2019.0020
Wei PL, et al. [Core Prescription Excavation of Launched Chinese Patent Medicines for Treating Different Syndromes of Angina Pectoris]. Zhongguo Zhong Yao Za Zhi. 2019;44(5):1041-1047. PubMed PMID: 30989867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Core prescription excavation of launched Chinese patent medicines for treating different syndromes of angina pectoris]. AU - Wei,Peng-Lu, AU - Gu,Hao, AU - Guan,Shuang, AU - Su,Yuan-Yuan, AU - Liu,Qiong, AU - Liu,Jun, AU - Wang,Zhong, PY - 2019/4/17/entrez PY - 2019/4/17/pubmed PY - 2019/8/15/medline KW - angina pectoris KW - core prescription KW - data mining KW - listed Chinese patent medicine SP - 1041 EP - 1047 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 44 IS - 5 N2 - To analyze the medication features and regularity of prescriptions of traditional Chinese medicines in treating patients with coronary heart disease angina pectoris based on the launched Chinese patent medicines. In the article,we collected all of the launched Chinese patent medicines for treating coronary heart disease and angina pectoris from the Chinese patent medicine value assessment information database,and set up a medical record normalized database,then carried out the classification of syndromes. The medication features and prescription rules for angina pectoris were analyzed by frequency statistics and association rules(IBM SPSS Modeler 14. 1 Premiums software,Apriori algorithm). Finally,a total of 170 prescriptions were selected,and 197 Chinese herbs were included,involving to totally 11 syndrome types,in which blood stasis syndrome,Qi stagnation and blood stasis syndrome,Qi deficiency and blood stasis syndrome,Qi-Yin deficiency and blood stasis syndrome were the main syndrome types. The frequency of single-herb medicines for the four main syndrome types,the combination of commonly used medicines,and the core prescriptions were summarized. After comparing the core prescriptions of the four syndrome types,we could analyze the medication features and prescription rules. In conclusion,the therapeutic principle is blood-activating and stasis-dissolving,and consideration was also given to promoting Qi,invigorating Qi and resuscitation and invigorating Qi-Yin. The main medicines include Danshen(Salvia Miltiorrhizae Radix et Rhizoma) and Chuan-xiong(Chuanxiong Rhizoma). According to different types of syndromes,Chinese herbal medicines are added,such as Jiangxiang(Dalbergiae Odoriferae Lignum), Chishao(Paeoniaeradix Rubra), Sanqi(Notoginseng Radix et Rhizoma), Honghua(Carthami Flos),Bingpian(Borneolum Syntheticum),Renshen(Ginseng Radix et Rhizoma). Frequency statistics and association rules are combined to explore the medication features and core prescriptions,which provide ideas for the treatment of angina pectoris and the development of new drugs. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/30989867/[Core_prescription_excavation_of_launched_Chinese_patent_medicines_for_treating_different_syndromes_of_angina_pectoris]_ L2 - https://medlineplus.gov/angina.html DB - PRIME DP - Unbound Medicine ER -