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[Nature-effect relationship research of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos based on nature combination].
Zhongguo Zhong Yao Za Zhi. 2019 Jan; 44(2):224-228.ZZ

Abstract

Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are commonly traditional Chinese medicines with invigorating blood circulation and eliminating blood stasis,but they are different in effects due to differences in five tastes and four properties. In this study,Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are selected as research vectors to obtain the active ingredients and targets through TCMD,TCMSP database and Ch EMBL database. The protein interaction information of the target is used to obtain from STRING online database,then imported into Cytoscape software to plot the protein interaction network and perform GO enrichment analysis.The results show that the heart-liver protein interaction network,involving blood circulation and hepatic lipid metabolism,thereby exerting the effect of activating blood circulation. The cold-bitter protein interaction network involves the biological process of vasoconstriction,thereby exerting cooling blood and the efficacy of eliminating phlegm. The warm-pungent protein interaction network involves blood coagulation,lipid metabolism and other biological processes to play the role of phlegm pain. Through analysis,it is found that the relationship between pharmacological efficacy and medicinal properties has a certain degree of specificity,which facilitates the subsequent scientific and systematic study of medicinal properties on the basis of this study.

Authors+Show Affiliations

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

30989937

Citation

Hou, Ning, et al. "[Nature-effect Relationship Research of Salviae Miltiorrhizae Radix Et Rhizoma and Carthami Flos Based On Nature Combination]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 44, no. 2, 2019, pp. 224-228.
Hou N, Wu DX, Liu M, et al. [Nature-effect relationship research of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos based on nature combination]. Zhongguo Zhong Yao Za Zhi. 2019;44(2):224-228.
Hou, N., Wu, D. X., Liu, M., Li, J., Zhang, Y. L., & Qiao, Y. J. (2019). [Nature-effect relationship research of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos based on nature combination]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 44(2), 224-228. https://doi.org/10.19540/j.cnki.cjcmm.20180903.002
Hou N, et al. [Nature-effect Relationship Research of Salviae Miltiorrhizae Radix Et Rhizoma and Carthami Flos Based On Nature Combination]. Zhongguo Zhong Yao Za Zhi. 2019;44(2):224-228. PubMed PMID: 30989937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Nature-effect relationship research of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos based on nature combination]. AU - Hou,Ning, AU - Wu,Dong-Xue, AU - Liu,Min, AU - Li,Jing, AU - Zhang,Yan-Ling, AU - Qiao,Yan-Jiang, PY - 2019/4/17/entrez PY - 2019/4/17/pubmed PY - 2019/8/6/medline KW - Carthami Flos KW - Salviae Miltiorrhizae Radix et Rhizoma KW - cold-bitter KW - nature combination KW - promoting blood circulation and removing blood stasis KW - warm-pungent SP - 224 EP - 228 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 44 IS - 2 N2 - Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are commonly traditional Chinese medicines with invigorating blood circulation and eliminating blood stasis,but they are different in effects due to differences in five tastes and four properties. In this study,Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are selected as research vectors to obtain the active ingredients and targets through TCMD,TCMSP database and Ch EMBL database. The protein interaction information of the target is used to obtain from STRING online database,then imported into Cytoscape software to plot the protein interaction network and perform GO enrichment analysis.The results show that the heart-liver protein interaction network,involving blood circulation and hepatic lipid metabolism,thereby exerting the effect of activating blood circulation. The cold-bitter protein interaction network involves the biological process of vasoconstriction,thereby exerting cooling blood and the efficacy of eliminating phlegm. The warm-pungent protein interaction network involves blood coagulation,lipid metabolism and other biological processes to play the role of phlegm pain. Through analysis,it is found that the relationship between pharmacological efficacy and medicinal properties has a certain degree of specificity,which facilitates the subsequent scientific and systematic study of medicinal properties on the basis of this study. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/30989937/[Nature_effect_relationship_research_of_Salviae_Miltiorrhizae_Radix_et_Rhizoma_and_Carthami_Flos_based_on_nature_combination]_ DB - PRIME DP - Unbound Medicine ER -