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Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation with Infants' Parameters.
Breastfeed Med 2019 Jul/Aug; 14(6):404-407BM

Abstract

Background:

Breastfeeding provides optimal nutrition and health protection for the infant; it contains many anti-inflammatory factors, including transforming growth factor beta-1 (TGF-β1). Our study aimed to measure the level of TGF-β1 in human milk and to find its correlation with some infant anthropometric characteristics. Subjects and

Methods:

A milk sample was collected from 84 mothers and the level of TGF-β1 was measured using enzyme-linked immunosorbent assay.

Results:

TGF-β1 was significantly higher in vegetarian mothers compared with nonvegetarian mothers (p = 0.044). Additionally, the mean value of breast milk TGF-β1 was significantly higher in mothers using contraceptive pills compared with those who do not (p = 0.021). Also, the mean value of TGF-β1 was significantly higher in infants 3-6 months than those <3 months (p = 0.010); also there was a significant difference regarding infants' weight and length with average weight and length (p = 0.042) and (p = 0.009), respectively.

Conclusions:

TGF-β1 in human milk may play a role in infants' growth and development; mothers' diet is known to influence TGF-β1 level and its relation to infants' age and weight. Contraceptive method could have an influence on TGF-β1 levels during breastfeeding.

Authors+Show Affiliations

1 Department of Pediatrics, National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt.2 Faculty of Medicine, Cairo University, Cairo, Egypt.2 Faculty of Medicine, Cairo University, Cairo, Egypt.3 Central Labs of Egypt, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30990330

Citation

Alsharnoubi, Jehan, et al. "Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation With Infants' Parameters." Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine, vol. 14, no. 6, 2019, pp. 404-407.
Alsharnoubi J, Ishaak M, Elsheikh S, et al. Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation with Infants' Parameters. Breastfeed Med. 2019;14(6):404-407.
Alsharnoubi, J., Ishaak, M., Elsheikh, S., & Ezzat, S. (2019). Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation with Infants' Parameters. Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine, 14(6), pp. 404-407. doi:10.1089/bfm.2018.0214.
Alsharnoubi J, et al. Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation With Infants' Parameters. Breastfeed Med. 2019;14(6):404-407. PubMed PMID: 30990330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation with Infants' Parameters. AU - Alsharnoubi,Jehan, AU - Ishaak,Marian, AU - Elsheikh,Suzan, AU - Ezzat,Sara, Y1 - 2019/04/26/ PY - 2019/4/17/pubmed PY - 2019/4/17/medline PY - 2019/4/17/entrez KW - TGF-β1 KW - human milk KW - infant anthropometric characteristics SP - 404 EP - 407 JF - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine JO - Breastfeed Med VL - 14 IS - 6 N2 - Background: Breastfeeding provides optimal nutrition and health protection for the infant; it contains many anti-inflammatory factors, including transforming growth factor beta-1 (TGF-β1). Our study aimed to measure the level of TGF-β1 in human milk and to find its correlation with some infant anthropometric characteristics. Subjects and Methods: A milk sample was collected from 84 mothers and the level of TGF-β1 was measured using enzyme-linked immunosorbent assay. Results: TGF-β1 was significantly higher in vegetarian mothers compared with nonvegetarian mothers (p = 0.044). Additionally, the mean value of breast milk TGF-β1 was significantly higher in mothers using contraceptive pills compared with those who do not (p = 0.021). Also, the mean value of TGF-β1 was significantly higher in infants 3-6 months than those <3 months (p = 0.010); also there was a significant difference regarding infants' weight and length with average weight and length (p = 0.042) and (p = 0.009), respectively. Conclusions: TGF-β1 in human milk may play a role in infants' growth and development; mothers' diet is known to influence TGF-β1 level and its relation to infants' age and weight. Contraceptive method could have an influence on TGF-β1 levels during breastfeeding. SN - 1556-8342 UR - https://www.unboundmedicine.com/medline/citation/30990330/Transforming_Growth_Factor_Beta-1_in_Human_Breast_Milk_and_Its_Correlation_with_Infants'_Parameters L2 - https://www.liebertpub.com/doi/full/10.1089/bfm.2018.0214?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -