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Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation with Infants' Parameters.

Abstract

Background:

Breastfeeding provides optimal nutrition and health protection for the infant; it contains many anti-inflammatory factors, including transforming growth factor beta-1 (TGF-β1). Our study aimed to measure the level of TGF-β1 in human milk and to find its correlation with some infant anthropometric characteristics. Subjects and

Methods:

A milk sample was collected from 84 mothers and the level of TGF-β1 was measured using enzyme-linked immunosorbent assay.

Results:

TGF-β1 was significantly higher in vegetarian mothers compared with nonvegetarian mothers (p = 0.044). Additionally, the mean value of breast milk TGF-β1 was significantly higher in mothers using contraceptive pills compared with those who do not (p = 0.021). Also, the mean value of TGF-β1 was significantly higher in infants 3-6 months than those <3 months (p = 0.010); also there was a significant difference regarding infants' weight and length with average weight and length (p = 0.042) and (p = 0.009), respectively.

Conclusions:

TGF-β1 in human milk may play a role in infants' growth and development; mothers' diet is known to influence TGF-β1 level and its relation to infants' age and weight. Contraceptive method could have an influence on TGF-β1 levels during breastfeeding.

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  • Authors+Show Affiliations

    ,

    1 Department of Pediatrics, National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt.

    ,

    2 Faculty of Medicine, Cairo University, Cairo, Egypt.

    ,

    2 Faculty of Medicine, Cairo University, Cairo, Egypt.

    3 Central Labs of Egypt, Cairo, Egypt.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    30990330

    Citation

    Alsharnoubi, Jehan, et al. "Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation With Infants' Parameters." Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine, 2019.
    Alsharnoubi J, Ishaak M, Elsheikh S, et al. Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation with Infants' Parameters. Breastfeed Med. 2019.
    Alsharnoubi, J., Ishaak, M., Elsheikh, S., & Ezzat, S. (2019). Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation with Infants' Parameters. Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine, doi:10.1089/bfm.2018.0214.
    Alsharnoubi J, et al. Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation With Infants' Parameters. Breastfeed Med. 2019 Apr 26; PubMed PMID: 30990330.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Transforming Growth Factor Beta-1 in Human Breast Milk and Its Correlation with Infants' Parameters. AU - Alsharnoubi,Jehan, AU - Ishaak,Marian, AU - Elsheikh,Suzan, AU - Ezzat,Sara, Y1 - 2019/04/26/ PY - 2019/4/17/pubmed PY - 2019/4/17/medline PY - 2019/4/17/entrez KW - TGF-β1 KW - human milk KW - infant anthropometric characteristics JF - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine JO - Breastfeed Med N2 - Background: Breastfeeding provides optimal nutrition and health protection for the infant; it contains many anti-inflammatory factors, including transforming growth factor beta-1 (TGF-β1). Our study aimed to measure the level of TGF-β1 in human milk and to find its correlation with some infant anthropometric characteristics. Subjects and Methods: A milk sample was collected from 84 mothers and the level of TGF-β1 was measured using enzyme-linked immunosorbent assay. Results: TGF-β1 was significantly higher in vegetarian mothers compared with nonvegetarian mothers (p = 0.044). Additionally, the mean value of breast milk TGF-β1 was significantly higher in mothers using contraceptive pills compared with those who do not (p = 0.021). Also, the mean value of TGF-β1 was significantly higher in infants 3-6 months than those <3 months (p = 0.010); also there was a significant difference regarding infants' weight and length with average weight and length (p = 0.042) and (p = 0.009), respectively. Conclusions: TGF-β1 in human milk may play a role in infants' growth and development; mothers' diet is known to influence TGF-β1 level and its relation to infants' age and weight. Contraceptive method could have an influence on TGF-β1 levels during breastfeeding. SN - 1556-8342 UR - https://www.unboundmedicine.com/medline/citation/30990330/Transforming_Growth_Factor_Beta-1_in_Human_Breast_Milk_and_Its_Correlation_with_Infants'_Parameters L2 - https://www.liebertpub.com/doi/full/10.1089/bfm.2018.0214?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -