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The clinical characteristic and prognostic factors of leptomeningeal metastasis in patients with non-small-cell lung cancer-a retrospective study from one single cancer institute.
Cancer Med. 2019 06; 8(6):2769-2776.CM

Abstract

BACKGROUND

Leptomeningeal metastasis (LM) is a detrimental complication of advanced non-small-cell lung cancer (NSCLC), and the optimal therapeutic approach for LM patients is in shortage. This retrospective study aimed to investigate the clinical features and prognostic factors of NSCLC patients with LM.

METHODS

We retrospectively reviewed the medical records of NSCLC patients with LM at the Shandong Cancer Hospital and Institute between July 2014 and March 2018. Identified cases had pathology-proven NSCLC with either positive cerebrospinal fluid cytology or leptomeningeal enhancement by MRI.

RESULTS

One hundred and thirty-six NSCLC patients (58 men, 78 women) with LM were enrolled in the retrospective study; median age was 55 years (range, 29-89 years). Fifty-one patients harbored EGFR mutations, ALK rearrangement was detected in 6 patients. Treatment for LM consisted of EGFR-TKIs alone in 11 patients, whole brain radiotherapy (WBRT) alone in 19 patients, Chemotherapy (ChT) alone in 12 patients, EGFR-TKIs plus WBRT in 30 patients, WBRT plus ChT in 25 patients, and EGFR-TKIs plus ChT in 24 patients. The median progression-free survival was 3.9 months (95% confidence interval [CI]: 3.178-4.622), and the median overall survival (OSLM) was 9.8 months (95% CI:7.5-12.1). Thirty patients who received WBRT plus EGFR-TKIs achieved longer survival than those who only received WBRT (median 13.6 vs 8.8 months; P = 0.027), but did not add any survival benefit than those only received EGFR-TKIs (median 13.6 vs 13.9 months; P = 0.352). A multivariate analysis indicated that KPS ≥ 80 (hazard ratio [HR] = 0.592, 95% CI:0.369-0.95; P = 0.03) and EGFR-TKIs (HR = 0.507, 95% CI:0.283-0.908; P = 0.022) after LM diagnosis were independent favourable predictors of survival, whereas smoking (HR = 1.181, 95% CI:1.009-3.246; P = 0.047) was an independent predictor of poor survival.

CONCLUSIONS

Our results suggest that patients with good performance statuses, non-smoking patients, and the administration of EGFR-TKIs might improve clinical outcomes in NSCLC patients with LM.

Authors+Show Affiliations

School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China. Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30993909

Citation

Yan, Weiwei, et al. "The Clinical Characteristic and Prognostic Factors of Leptomeningeal Metastasis in Patients With Non-small-cell Lung Cancer-a Retrospective Study From One Single Cancer Institute." Cancer Medicine, vol. 8, no. 6, 2019, pp. 2769-2776.
Yan W, Jing W, An N, et al. The clinical characteristic and prognostic factors of leptomeningeal metastasis in patients with non-small-cell lung cancer-a retrospective study from one single cancer institute. Cancer Med. 2019;8(6):2769-2776.
Yan, W., Jing, W., An, N., Tian, Y., Guo, D., Kong, L., Zhu, H., & Yu, J. (2019). The clinical characteristic and prognostic factors of leptomeningeal metastasis in patients with non-small-cell lung cancer-a retrospective study from one single cancer institute. Cancer Medicine, 8(6), 2769-2776. https://doi.org/10.1002/cam4.2156
Yan W, et al. The Clinical Characteristic and Prognostic Factors of Leptomeningeal Metastasis in Patients With Non-small-cell Lung Cancer-a Retrospective Study From One Single Cancer Institute. Cancer Med. 2019;8(6):2769-2776. PubMed PMID: 30993909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The clinical characteristic and prognostic factors of leptomeningeal metastasis in patients with non-small-cell lung cancer-a retrospective study from one single cancer institute. AU - Yan,Weiwei, AU - Jing,Wang, AU - An,Ning, AU - Tian,Yaru, AU - Guo,Dong, AU - Kong,Li, AU - Zhu,Hui, AU - Yu,Jinming, Y1 - 2019/04/16/ PY - 2019/02/11/received PY - 2019/03/27/revised PY - 2019/03/27/accepted PY - 2019/4/18/pubmed PY - 2020/7/7/medline PY - 2019/4/18/entrez KW - EGFR-TKIs KW - WBRT KW - leptomeningeal metastasis KW - non-small-cell lung cancer KW - survival SP - 2769 EP - 2776 JF - Cancer medicine JO - Cancer Med VL - 8 IS - 6 N2 - BACKGROUND: Leptomeningeal metastasis (LM) is a detrimental complication of advanced non-small-cell lung cancer (NSCLC), and the optimal therapeutic approach for LM patients is in shortage. This retrospective study aimed to investigate the clinical features and prognostic factors of NSCLC patients with LM. METHODS: We retrospectively reviewed the medical records of NSCLC patients with LM at the Shandong Cancer Hospital and Institute between July 2014 and March 2018. Identified cases had pathology-proven NSCLC with either positive cerebrospinal fluid cytology or leptomeningeal enhancement by MRI. RESULTS: One hundred and thirty-six NSCLC patients (58 men, 78 women) with LM were enrolled in the retrospective study; median age was 55 years (range, 29-89 years). Fifty-one patients harbored EGFR mutations, ALK rearrangement was detected in 6 patients. Treatment for LM consisted of EGFR-TKIs alone in 11 patients, whole brain radiotherapy (WBRT) alone in 19 patients, Chemotherapy (ChT) alone in 12 patients, EGFR-TKIs plus WBRT in 30 patients, WBRT plus ChT in 25 patients, and EGFR-TKIs plus ChT in 24 patients. The median progression-free survival was 3.9 months (95% confidence interval [CI]: 3.178-4.622), and the median overall survival (OSLM) was 9.8 months (95% CI:7.5-12.1). Thirty patients who received WBRT plus EGFR-TKIs achieved longer survival than those who only received WBRT (median 13.6 vs 8.8 months; P = 0.027), but did not add any survival benefit than those only received EGFR-TKIs (median 13.6 vs 13.9 months; P = 0.352). A multivariate analysis indicated that KPS ≥ 80 (hazard ratio [HR] = 0.592, 95% CI:0.369-0.95; P = 0.03) and EGFR-TKIs (HR = 0.507, 95% CI:0.283-0.908; P = 0.022) after LM diagnosis were independent favourable predictors of survival, whereas smoking (HR = 1.181, 95% CI:1.009-3.246; P = 0.047) was an independent predictor of poor survival. CONCLUSIONS: Our results suggest that patients with good performance statuses, non-smoking patients, and the administration of EGFR-TKIs might improve clinical outcomes in NSCLC patients with LM. SN - 2045-7634 UR - https://www.unboundmedicine.com/medline/citation/30993909/The_clinical_characteristic_and_prognostic_factors_of_leptomeningeal_metastasis_in_patients_with_non_small_cell_lung_cancer_a_retrospective_study_from_one_single_cancer_institute_ L2 - https://doi.org/10.1002/cam4.2156 DB - PRIME DP - Unbound Medicine ER -