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Epidemic non-A, non-B hepatitis in patients from Pakistan.

Abstract

Epidemic non-A, non-B hepatitis was diagnosed in three young Pakistani men during a 10-month period at the Los Angeles County-University of Southern California Medical Center. All three patients had recently visited or lived in Karachi, Pakistan. None had serologic markers of hepatitis B virus infection or IgM antibody (acute-phase) to hepatitis A virus. A liver biopsy from one patient showed marked cholestasis and cholangiolar transformation of hepatocytes, a pattern previously described in patients with epidemic non-A, non-B hepatitis. Immune electron microscopy of a stool specimen obtained from this patient 10 days after the onset of symptoms showed virus-like particles, 27 nm in diameter, that were specifically aggregated by antibody contained in acute-phase sera from the three Pakistani patients, from patients with non-A, non-B hepatitis in Burma and Nepal, and from an experimentally infected marmoset. Recognition of three separate cases of probable epidemic-type non-A, non-B hepatitis in patients at one institution during such a short time suggests that Pakistan is endemic for this infection and that the disease may be more commonly spread to the United States than is now presumed.

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  • Authors

    , , , , ,

    Source

    Annals of internal medicine 106:2 1987 Feb pg 227-30

    MeSH

    Adult
    California
    Disease Outbreaks
    Feces
    Hepatitis Antibodies
    Hepatitis C
    Hepatitis, Viral, Human
    Humans
    Male
    Microscopy, Electron
    Pakistan
    Virion

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    3099621

    Citation

    De Cock, K M., et al. "Epidemic non-A, non-B Hepatitis in Patients From Pakistan." Annals of Internal Medicine, vol. 106, no. 2, 1987, pp. 227-30.
    De Cock KM, Bradley DW, Sandford NL, et al. Epidemic non-A, non-B hepatitis in patients from Pakistan. Ann Intern Med. 1987;106(2):227-30.
    De Cock, K. M., Bradley, D. W., Sandford, N. L., Govindarajan, S., Maynard, J. E., & Redeker, A. G. (1987). Epidemic non-A, non-B hepatitis in patients from Pakistan. Annals of Internal Medicine, 106(2), pp. 227-30.
    De Cock KM, et al. Epidemic non-A, non-B Hepatitis in Patients From Pakistan. Ann Intern Med. 1987;106(2):227-30. PubMed PMID: 3099621.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemic non-A, non-B hepatitis in patients from Pakistan. AU - De Cock,K M, AU - Bradley,D W, AU - Sandford,N L, AU - Govindarajan,S, AU - Maynard,J E, AU - Redeker,A G, PY - 1987/2/1/pubmed PY - 1987/2/1/medline PY - 1987/2/1/entrez SP - 227 EP - 30 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 106 IS - 2 N2 - Epidemic non-A, non-B hepatitis was diagnosed in three young Pakistani men during a 10-month period at the Los Angeles County-University of Southern California Medical Center. All three patients had recently visited or lived in Karachi, Pakistan. None had serologic markers of hepatitis B virus infection or IgM antibody (acute-phase) to hepatitis A virus. A liver biopsy from one patient showed marked cholestasis and cholangiolar transformation of hepatocytes, a pattern previously described in patients with epidemic non-A, non-B hepatitis. Immune electron microscopy of a stool specimen obtained from this patient 10 days after the onset of symptoms showed virus-like particles, 27 nm in diameter, that were specifically aggregated by antibody contained in acute-phase sera from the three Pakistani patients, from patients with non-A, non-B hepatitis in Burma and Nepal, and from an experimentally infected marmoset. Recognition of three separate cases of probable epidemic-type non-A, non-B hepatitis in patients at one institution during such a short time suggests that Pakistan is endemic for this infection and that the disease may be more commonly spread to the United States than is now presumed. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/3099621/Epidemic_non_A_non_B_hepatitis_in_patients_from_Pakistan_ L2 - https://www.annals.org/article.aspx?volume=106&issue=2&page=227 DB - PRIME DP - Unbound Medicine ER -