Tags

Type your tag names separated by a space and hit enter

Discovery and Characterization of Novel Bat Coronavirus Lineages from Kazakhstan.
Viruses. 2019 04 17; 11(4)V

Abstract

Coronaviruses are positive-stranded RNA viruses that infect a variety of hosts, resulting in a range of symptoms from gastrointestinal illness to respiratory distress. Bats are reservoirs for a high diversity of coronaviruses, and focused surveillance detected several strains genetically similar to MERS-coronavirus, SARS-coronavirus, and the human coronaviruses 229E and NL63. The bat fauna of central Asia, which link China to eastern Europe, are relatively less studied than other regions of the world. Kazakhstan is the world's ninth largest country; however, little is understood about the prevalence and diversity of bat-borne viruses. In this study, bat guano was collected from bat caves in three different sites of southern Kazakhstan that tested positive for coronaviruses. Our phylogenetic reconstruction indicates these are novel bat coronaviruses that belong to the genus Alphacoronavirus. In addition, two distinct lineages of Kazakhstan bat coronaviruses were detected. Both lineages are closely related to bat coronaviruses from China, France, Spain, and South Africa, suggesting that co-circulation of coronaviruses is common in multiple bat species with overlapping geographical distributions. Our study highlights the need for collaborative efforts in understudied countries to increase integrated surveillance capabilities toward better monitoring and detection of infectious diseases.

Links

PMC Free PDF

Authors+Show Affiliations

Mendenhall IH
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore. ian.mendenhall@duke-nus.edu.sg.
Kerimbayev AA
Research Institute for Biological Safety Problems, 080409 Gvardeiskiy, Kordaiskiy rayon, Zhambylskaya oblast, Kazakhstan. aslan_kerim@mail.ru.
Strochkov VM
Research Institute for Biological Safety Problems, 080409 Gvardeiskiy, Kordaiskiy rayon, Zhambylskaya oblast, Kazakhstan. vstrochkov@gmail.com.
Sultankulova KT
Research Institute for Biological Safety Problems, 080409 Gvardeiskiy, Kordaiskiy rayon, Zhambylskaya oblast, Kazakhstan. sultankul70@mail.ru.
Kopeyev SK
Research Institute for Biological Safety Problems, 080409 Gvardeiskiy, Kordaiskiy rayon, Zhambylskaya oblast, Kazakhstan. kopeyev85@mail.ru.
Su YCF
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore. yvonne.su@duke-nus.edu.sg.
Smith GJD
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore. gavin.smith@duke-nus.edu.sg. SingHealth Duke-NUS Global Health Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore 168753, Singapore. gavin.smith@duke-nus.edu.sg. Duke Global Health Institute, Duke University, Durham, NC 27710, USA. gavin.smith@duke-nus.edu.sg.
Orynbayev MB
Research Institute for Biological Safety Problems, 080409 Gvardeiskiy, Kordaiskiy rayon, Zhambylskaya oblast, Kazakhstan. omb65@mail.ru.

MeSH

AlphacoronavirusAnimalsChiropteraCoronavirus InfectionsDisease ReservoirsGenetic VariationKazakhstanPhylogenyPhylogeographyRNA, ViralRNA-Dependent RNA PolymeraseViral Proteins

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

30999711

Citation

Mendenhall, Ian H., et al. "Discovery and Characterization of Novel Bat Coronavirus Lineages From Kazakhstan." Viruses, vol. 11, no. 4, 2019.
Mendenhall IH, Kerimbayev AA, Strochkov VM, et al. Discovery and Characterization of Novel Bat Coronavirus Lineages from Kazakhstan. Viruses. 2019;11(4).
Mendenhall, I. H., Kerimbayev, A. A., Strochkov, V. M., Sultankulova, K. T., Kopeyev, S. K., Su, Y. C. F., Smith, G. J. D., & Orynbayev, M. B. (2019). Discovery and Characterization of Novel Bat Coronavirus Lineages from Kazakhstan. Viruses, 11(4). https://doi.org/10.3390/v11040356
Mendenhall IH, et al. Discovery and Characterization of Novel Bat Coronavirus Lineages From Kazakhstan. Viruses. 2019 04 17;11(4) PubMed PMID: 30999711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discovery and Characterization of Novel Bat Coronavirus Lineages from Kazakhstan. AU - Mendenhall,Ian H, AU - Kerimbayev,Aslan A, AU - Strochkov,Vitaliy M, AU - Sultankulova,Kulyaisan T, AU - Kopeyev,Syrym K, AU - Su,Yvonne C F, AU - Smith,Gavin J D, AU - Orynbayev,Mukhit B, Y1 - 2019/04/17/ PY - 2019/01/31/received PY - 2019/03/20/revised PY - 2019/04/09/accepted PY - 2019/4/20/entrez PY - 2019/4/20/pubmed PY - 2020/3/21/medline KW - Hypsugo savii KW - Kazakhstan KW - Myotis blythii KW - coronavirus KW - phylogeny KW - virus discovery JF - Viruses JO - Viruses VL - 11 IS - 4 N2 - Coronaviruses are positive-stranded RNA viruses that infect a variety of hosts, resulting in a range of symptoms from gastrointestinal illness to respiratory distress. Bats are reservoirs for a high diversity of coronaviruses, and focused surveillance detected several strains genetically similar to MERS-coronavirus, SARS-coronavirus, and the human coronaviruses 229E and NL63. The bat fauna of central Asia, which link China to eastern Europe, are relatively less studied than other regions of the world. Kazakhstan is the world's ninth largest country; however, little is understood about the prevalence and diversity of bat-borne viruses. In this study, bat guano was collected from bat caves in three different sites of southern Kazakhstan that tested positive for coronaviruses. Our phylogenetic reconstruction indicates these are novel bat coronaviruses that belong to the genus Alphacoronavirus. In addition, two distinct lineages of Kazakhstan bat coronaviruses were detected. Both lineages are closely related to bat coronaviruses from China, France, Spain, and South Africa, suggesting that co-circulation of coronaviruses is common in multiple bat species with overlapping geographical distributions. Our study highlights the need for collaborative efforts in understudied countries to increase integrated surveillance capabilities toward better monitoring and detection of infectious diseases. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/30999711/Discovery_and_Characterization_of_Novel_Bat_Coronavirus_Lineages_from_Kazakhstan_ DB - PRIME DP - Unbound Medicine ER -