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Association of Kaphaja and Kapha-Pittaja Prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes.
Ayu 2018 Jul-Sep; 39(3):146-150AYU

Abstract

Background and Objectives

Type 2 diabetes is a multifactorial disorder that results from the interaction between genetic predisposition and environmental factors. Different Prakriti (body constitution) individuals have different susceptibility for the diseases, and this Prakriti is determined by both genetic and environmental factor. This study was undertaken to determine the association status of Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C with type 2 diabetes and Prakriti.

Materials and Methods

After informed consent, 54 patients with type 2 diabetes and 56 individuals as normal controls were analyzed. Their constitution and pathological data were collected and MTHFR C677T and A1298C genotypes were determined.

Results

Kapha/Kapha-Pittaja Prakriti were associated and found to be strong risk factors (Chi-square test = 39.67, P < 0.00001, odds ratio [OR] = 16.133, 95% confidence interval [CI] = 6.32-41.20) for type 2 diabetes. MTHFR C677T was associated (Chi-square test = 7.743, P = 0.02) with type 2 diabetes where the major CC genotype was found to be a risk for type 2 diabetes (OR = 3.78, 95% CI = 1.14-12.45). A1298C was not associated with type 2 diabetes (Chi-square test = 2.264, P = 0.322). None of the Prakriti was associated with C677T and A1298C variants.

Interpretation and Conclusion

In the present study, an extremely strong association between Prakriti (Kaphaja/Kapha-Pittaja) and type 2 diabetes (P < 0.00001) was detected. The present study gives a strong clue for the association of Prakriti (body constitutional) and clinical phenotype.

Authors+Show Affiliations

Department of Vikriti Vigyan, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Center for Genetic Disorders, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Department of Vikriti Vigyan, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Center for Genetic Disorders, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Department of Vikriti Vigyan, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31000991

Citation

Gupta, Archana, et al. "Association of Kaphaja and Kapha-Pittaja Prakriti and Methylenetetrahydrofolate Reductase C677T Allele With Type 2 Diabetes." Ayu, vol. 39, no. 3, 2018, pp. 146-150.
Gupta A, Ali A, Tewari P, et al. Association of Kaphaja and Kapha-Pittaja Prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes. Ayu. 2018;39(3):146-150.
Gupta, A., Ali, A., Tewari, P., Agrawal, N. K., Patel, R., & Byadgi, P. S. (2018). Association of Kaphaja and Kapha-Pittaja Prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes. Ayu, 39(3), pp. 146-150. doi:10.4103/ayu.AYU_230_18.
Gupta A, et al. Association of Kaphaja and Kapha-Pittaja Prakriti and Methylenetetrahydrofolate Reductase C677T Allele With Type 2 Diabetes. Ayu. 2018;39(3):146-150. PubMed PMID: 31000991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Kaphaja and Kapha-Pittaja Prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes. AU - Gupta,Archana, AU - Ali,Akhtar, AU - Tewari,Priyadarshini, AU - Agrawal,Neeraj Kumar, AU - Patel,Rashmi, AU - Byadgi,Parameswarappa Shivappa, PY - 2019/4/20/entrez PY - 2019/4/20/pubmed PY - 2019/4/20/medline KW - Methylenetetrahydrofolate reductase KW - Prakriti KW - type 2 diabetes SP - 146 EP - 150 JF - Ayu JO - Ayu VL - 39 IS - 3 N2 - Background and Objectives: Type 2 diabetes is a multifactorial disorder that results from the interaction between genetic predisposition and environmental factors. Different Prakriti (body constitution) individuals have different susceptibility for the diseases, and this Prakriti is determined by both genetic and environmental factor. This study was undertaken to determine the association status of Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C with type 2 diabetes and Prakriti. Materials and Methods: After informed consent, 54 patients with type 2 diabetes and 56 individuals as normal controls were analyzed. Their constitution and pathological data were collected and MTHFR C677T and A1298C genotypes were determined. Results: Kapha/Kapha-Pittaja Prakriti were associated and found to be strong risk factors (Chi-square test = 39.67, P < 0.00001, odds ratio [OR] = 16.133, 95% confidence interval [CI] = 6.32-41.20) for type 2 diabetes. MTHFR C677T was associated (Chi-square test = 7.743, P = 0.02) with type 2 diabetes where the major CC genotype was found to be a risk for type 2 diabetes (OR = 3.78, 95% CI = 1.14-12.45). A1298C was not associated with type 2 diabetes (Chi-square test = 2.264, P = 0.322). None of the Prakriti was associated with C677T and A1298C variants. Interpretation and Conclusion: In the present study, an extremely strong association between Prakriti (Kaphaja/Kapha-Pittaja) and type 2 diabetes (P < 0.00001) was detected. The present study gives a strong clue for the association of Prakriti (body constitutional) and clinical phenotype. SN - 0974-8520 UR - https://www.unboundmedicine.com/medline/citation/31000991/Association_of_Kaphaja_and_Kapha-Pittaja_Prakriti_and_methylenetetrahydrofolate_reductase_C677T_allele_with_type_2_diabetes L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31000991/ DB - PRIME DP - Unbound Medicine ER -