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CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors.
J Clin Exp Dent 2019; 11(3):e213-e218JC

Abstract

Background

Ecto-5'-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors.

Material and Methods

In this retrospective study, immunohistochemical expression of CD73 was evaluated in 25 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinomas using the Envision technique. Labeling indices of CD73 expression were calculated and compared between lesions.

Results

Immunohistochemical analysis demonstrated that the CD73 expression was significantly higher in salivary gland tumors than in normal salivary gland tissue (p<0.001). CD73 expression was significantly higher in mucoepidermoid carcinoma and adenoid cystic carcinoma compared to pleomorphic adenoma p<0.001). In addition, the expression of CD73 was significantly higher in lymph node metastasizing cancers compared to non-metastasizing malignancies (P<0.001). In contrast, there was no significant association between CD73 expression and other clinicopathological variables such as age, gender, tumor size and distant metastasis (P>0.05).

Conclusions

The findings suggest that CD73 can be an independent and useful biomarker for predicting the clinical behavior of salivary gland tumors. Key words:Ecto-5'-nucleotidase, immunohistochemistry, salivary gland tumors.

Authors+Show Affiliations

Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Undergraduate Student, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31001389

Citation

Ranjbar, Mohammad-Ali, et al. "CD73 a Novel Marker for the Diagnosis of Benign and Malignant Salivary Gland Tumors." Journal of Clinical and Experimental Dentistry, vol. 11, no. 3, 2019, pp. e213-e218.
Ranjbar MA, Ranjbar Z, Zahed M, et al. CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors. J Clin Exp Dent. 2019;11(3):e213-e218.
Ranjbar, M. A., Ranjbar, Z., Zahed, M., & Nikookar, N. (2019). CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors. Journal of Clinical and Experimental Dentistry, 11(3), pp. e213-e218. doi:10.4317/jced.54918.
Ranjbar MA, et al. CD73 a Novel Marker for the Diagnosis of Benign and Malignant Salivary Gland Tumors. J Clin Exp Dent. 2019;11(3):e213-e218. PubMed PMID: 31001389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors. AU - Ranjbar,Mohammad-Ali, AU - Ranjbar,Zahra, AU - Zahed,Maryam, AU - Nikookar,Negar, Y1 - 2019/03/01/ PY - 2018/04/11/received PY - 2018/09/02/accepted PY - 2019/4/20/entrez PY - 2019/4/20/pubmed PY - 2019/4/20/medline SP - e213 EP - e218 JF - Journal of clinical and experimental dentistry JO - J Clin Exp Dent VL - 11 IS - 3 N2 - Background: Ecto-5'-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors. Material and Methods: In this retrospective study, immunohistochemical expression of CD73 was evaluated in 25 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinomas using the Envision technique. Labeling indices of CD73 expression were calculated and compared between lesions. Results: Immunohistochemical analysis demonstrated that the CD73 expression was significantly higher in salivary gland tumors than in normal salivary gland tissue (p<0.001). CD73 expression was significantly higher in mucoepidermoid carcinoma and adenoid cystic carcinoma compared to pleomorphic adenoma p<0.001). In addition, the expression of CD73 was significantly higher in lymph node metastasizing cancers compared to non-metastasizing malignancies (P<0.001). In contrast, there was no significant association between CD73 expression and other clinicopathological variables such as age, gender, tumor size and distant metastasis (P>0.05). Conclusions: The findings suggest that CD73 can be an independent and useful biomarker for predicting the clinical behavior of salivary gland tumors. Key words:Ecto-5'-nucleotidase, immunohistochemistry, salivary gland tumors. SN - 1989-5488 UR - https://www.unboundmedicine.com/medline/citation/31001389/CD73_a_novel_marker_for_the_diagnosis_of_benign_and_malignant_salivary_gland_tumors L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31001389/ DB - PRIME DP - Unbound Medicine ER -