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Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in solid organ transplant recipients: Guidelines from the American Society of Transplantation Community of Practice.
Clin Transplant. 2019 09; 33(9):e13564.CT

Abstract

These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice address the prevention and management of Clostridium difficile infection in solid organ transplant (SOT) recipients. Clostridioides (formerly Clostridium) difficile infection (CDI) is among the most common hospital acquired infections. In SOT recipients, the incidence of CDI varies by type and number or organs transplanted. While a meta-analysis of published literature found the prevalence of postoperative CDI in the general surgical population to be approximately 0.51%, the prevalence of CDI that is seen in the solid organ transplant population ranges from a low of 3.2% in the pancreatic transplant population to 12.7% in those receiving multiple organ transplants. There are no randomized, controlled trials evaluating the management of CDI in the SOT population. Herein is a review and summary of the currently available literature that has been synthesized into updated treatment guidelines for the management of CDI in the SOT population.

Authors+Show Affiliations

Department of Medicine, Section of Infectious Diseases & Global Health, University of Chicago, Chicago, Illinois.Department of Medicine, Division of Infectious Diseases, School of Medicine, Washington University, St. Louis, Missouri.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31002420

Citation

Mullane, Kathleen M., et al. "Management of Clostridioides (formerly Clostridium) Difficile Infection (CDI) in Solid Organ Transplant Recipients: Guidelines From the American Society of Transplantation Community of Practice." Clinical Transplantation, vol. 33, no. 9, 2019, pp. e13564.
Mullane KM, Dubberke ER, AST ID Community of Practice. Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in solid organ transplant recipients: Guidelines from the American Society of Transplantation Community of Practice. Clin Transplant. 2019;33(9):e13564.
Mullane, K. M., & Dubberke, E. R. (2019). Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in solid organ transplant recipients: Guidelines from the American Society of Transplantation Community of Practice. Clinical Transplantation, 33(9), e13564. https://doi.org/10.1111/ctr.13564
Mullane KM, Dubberke ER, AST ID Community of Practice. Management of Clostridioides (formerly Clostridium) Difficile Infection (CDI) in Solid Organ Transplant Recipients: Guidelines From the American Society of Transplantation Community of Practice. Clin Transplant. 2019;33(9):e13564. PubMed PMID: 31002420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in solid organ transplant recipients: Guidelines from the American Society of Transplantation Community of Practice. AU - Mullane,Kathleen M, AU - Dubberke,Erik R, AU - ,, Y1 - 2019/06/20/ PY - 2019/04/01/received PY - 2019/04/09/accepted PY - 2019/4/20/pubmed PY - 2020/10/2/medline PY - 2019/4/20/entrez KW - Clostridium difficile KW - antibiotic-associated diarrhea KW - nosocomial infection KW - pseudomembranous colitis KW - solid organ transplant SP - e13564 EP - e13564 JF - Clinical transplantation JO - Clin Transplant VL - 33 IS - 9 N2 - These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice address the prevention and management of Clostridium difficile infection in solid organ transplant (SOT) recipients. Clostridioides (formerly Clostridium) difficile infection (CDI) is among the most common hospital acquired infections. In SOT recipients, the incidence of CDI varies by type and number or organs transplanted. While a meta-analysis of published literature found the prevalence of postoperative CDI in the general surgical population to be approximately 0.51%, the prevalence of CDI that is seen in the solid organ transplant population ranges from a low of 3.2% in the pancreatic transplant population to 12.7% in those receiving multiple organ transplants. There are no randomized, controlled trials evaluating the management of CDI in the SOT population. Herein is a review and summary of the currently available literature that has been synthesized into updated treatment guidelines for the management of CDI in the SOT population. SN - 1399-0012 UR - https://www.unboundmedicine.com/medline/citation/31002420/Management_of_Clostridioides__formerly_Clostridium__difficile_infection__CDI__in_solid_organ_transplant_recipients:_Guidelines_from_the_American_Society_of_Transplantation_Community_of_Practice_ L2 - https://doi.org/10.1111/ctr.13564 DB - PRIME DP - Unbound Medicine ER -