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Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO3) exposure on Zebrafish (Danio rerio).

Abstract

The present study evaluated silver nanoparticle (AgNPs) toxicity using biomarkers of oxidative and metabolic stress, immunological impairment and cellular damage in zebrafish (Danio rerio), as well as the optimal dose of vitamin E neutralizing undesirable effects. Fish were fed for ten days and eight study groups were investigated: controls, AgNPs exposure alone (1.5 mg L-1) and combined with three different vitamin E doses (1.5 mg L-1 of AgNPs + vitamin E 100, 200 or 400 mg kg-1 of food), also one positive control group exposed to AgNO3 alone or combined with the same vitamin E doses. D. rerio exposed to AgNPs alone or combined with the lower vitamin E dose showed overall worse results in comparison with the control groups and the groups combining nanoparticles and 200 or 400 mg kg-1 of food of vitamin E-supplemented diet. AgNPs caused cell impairment by increasing LDH activity and cortisol levels, generated oxidative stress by inhibiting SOD and CAT activity and immunosuppression by inhibiting ACH50 and lysozyme activity. The groups exposed to Ag salt showed the same response-pattern found for the NPs groups, reinforcing that Ag toxicity of AgNPs is mediated by Ag+. In conclusion, although AgNPs are toxic to Danio rerio, vitamin E supplementation at 200 or 400 mg kg-1 can act protectively against its toxic effects.

Authors+Show Affiliations

Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.Young Researchers and Elite Club, Yasooj Branch, Islamic Azad University, Yasooj, Iran.Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand; Science and Technology Research Institute, Chiang Mai University, 239 Huay keaw Rd., Suthep, Muang, Chiang Mai 50200, Thailand. Electronic address: hien.d@cmu.ac.th.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31004833

Citation

Hedayati, Seyed Aliakbar, et al. "Protective Effect of Dietary Vitamin E On Immunological and Biochemical Induction Through Silver Nanoparticles (AgNPs) Inclusion in Diet and Silver Salt (AgNO3) Exposure On Zebrafish (Danio Rerio)." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 222, 2019, pp. 100-107.
Hedayati SA, Farsani HG, Naserabad SS, et al. Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO3) exposure on Zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. 2019;222:100-107.
Hedayati, S. A., Farsani, H. G., Naserabad, S. S., Hoseinifar, S. H., & Van Doan, H. (2019). Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO3) exposure on Zebrafish (Danio rerio). Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 222, 100-107. https://doi.org/10.1016/j.cbpc.2019.04.004
Hedayati SA, et al. Protective Effect of Dietary Vitamin E On Immunological and Biochemical Induction Through Silver Nanoparticles (AgNPs) Inclusion in Diet and Silver Salt (AgNO3) Exposure On Zebrafish (Danio Rerio). Comp Biochem Physiol C Toxicol Pharmacol. 2019;222:100-107. PubMed PMID: 31004833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO3) exposure on Zebrafish (Danio rerio). AU - Hedayati,Seyed Aliakbar, AU - Farsani,Hamed Ghafari, AU - Naserabad,Saeid Shahbazi, AU - Hoseinifar,Seyed Hossein, AU - Van Doan,Hien, Y1 - 2019/04/18/ PY - 2019/01/21/received PY - 2019/04/06/revised PY - 2019/04/08/accepted PY - 2019/4/21/pubmed PY - 2019/7/2/medline PY - 2019/4/21/entrez KW - Alpha-tocopherol KW - Immunosuppression KW - Nanosilver KW - Oxidative stress KW - Silver nitrate KW - Zebrafish SP - 100 EP - 107 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 222 N2 - The present study evaluated silver nanoparticle (AgNPs) toxicity using biomarkers of oxidative and metabolic stress, immunological impairment and cellular damage in zebrafish (Danio rerio), as well as the optimal dose of vitamin E neutralizing undesirable effects. Fish were fed for ten days and eight study groups were investigated: controls, AgNPs exposure alone (1.5 mg L-1) and combined with three different vitamin E doses (1.5 mg L-1 of AgNPs + vitamin E 100, 200 or 400 mg kg-1 of food), also one positive control group exposed to AgNO3 alone or combined with the same vitamin E doses. D. rerio exposed to AgNPs alone or combined with the lower vitamin E dose showed overall worse results in comparison with the control groups and the groups combining nanoparticles and 200 or 400 mg kg-1 of food of vitamin E-supplemented diet. AgNPs caused cell impairment by increasing LDH activity and cortisol levels, generated oxidative stress by inhibiting SOD and CAT activity and immunosuppression by inhibiting ACH50 and lysozyme activity. The groups exposed to Ag salt showed the same response-pattern found for the NPs groups, reinforcing that Ag toxicity of AgNPs is mediated by Ag+. In conclusion, although AgNPs are toxic to Danio rerio, vitamin E supplementation at 200 or 400 mg kg-1 can act protectively against its toxic effects. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/31004833/Protective_effect_of_dietary_vitamin_E_on_immunological_and_biochemical_induction_through_silver_nanoparticles__AgNPs__inclusion_in_diet_and_silver_salt__AgNO3__exposure_on_Zebrafish__Danio_rerio__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(19)30040-7 DB - PRIME DP - Unbound Medicine ER -