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Neotropical wild rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as important carriers of pathogenic renal Leptospira in the Atlantic forest, in Brazil.
Res Vet Sci. 2019 Jun; 124:280-283.RV

Abstract

Leptospirosis is an important worldwide zoonosis, caused by a bacterium of the genus Leptospira. For a better understanding of the disease, it is relevant the application of the one health concept. The Atlantic Forest is considered a biodiversity hotspot, with a great endemism of species and despite its importance and proximity to urban areas, the potential role of its fauna as carriers of infectious agents is still poorly understood. Although it is well-known that rats and mice are key reservoirs of leptospires, particularly Rattus norvegicus, wild rodents have also been revealed as reservoirs of leptospiral strains. Thus, the purpose of this study was to investigate the role of the sigmodontine rodents from genera Akodon and Oligoryzomys as pathogenic Leptospira carriers in the Atlantic Forest. We studied 52 Akodon spp. and 15 Oligoryzomys spp. from three areas. Overall 30% were PCR-positive for pathogenic Leptospira, 27% (14/52) Akodon spp. and 40% (6/15) Oligoryzomys spp. DNA sequencing of LipL32 gene confirmed nine species as pathogenic Leptospira. This remarkable incidence of leptospiral carriage within wild genera emphasizes the role of these rodents as carriers of leptospires throughout in this environment.

Authors+Show Affiliations

Fluminense Federal University, Laboratory of Veterinary Bacteriology, Biomedical Institute, 101 Prof. Hernani Mello Street, Niterói, Rio de Janeiro, Brazil.Fluminense Federal University, Laboratory of Veterinary Bacteriology, Biomedical Institute, 101 Prof. Hernani Mello Street, Niterói, Rio de Janeiro, Brazil.Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro, RJ 21040-360, Brazil.Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro, RJ 21040-360, Brazil.Fluminense Federal University, Laboratory of Veterinary Bacteriology, Biomedical Institute, 101 Prof. Hernani Mello Street, Niterói, Rio de Janeiro, Brazil. Electronic address: wlilenbaum@id.uff.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31004919

Citation

Vieira, Anahi S., et al. "Neotropical Wild Rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as Important Carriers of Pathogenic Renal Leptospira in the Atlantic Forest, in Brazil." Research in Veterinary Science, vol. 124, 2019, pp. 280-283.
Vieira AS, Di Azevedo MIN, D'Andrea PS, et al. Neotropical wild rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as important carriers of pathogenic renal Leptospira in the Atlantic forest, in Brazil. Res Vet Sci. 2019;124:280-283.
Vieira, A. S., Di Azevedo, M. I. N., D'Andrea, P. S., do Val Vilela, R., & Lilenbaum, W. (2019). Neotropical wild rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as important carriers of pathogenic renal Leptospira in the Atlantic forest, in Brazil. Research in Veterinary Science, 124, 280-283. https://doi.org/10.1016/j.rvsc.2019.04.001
Vieira AS, et al. Neotropical Wild Rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as Important Carriers of Pathogenic Renal Leptospira in the Atlantic Forest, in Brazil. Res Vet Sci. 2019;124:280-283. PubMed PMID: 31004919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neotropical wild rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as important carriers of pathogenic renal Leptospira in the Atlantic forest, in Brazil. AU - Vieira,Anahi S, AU - Di Azevedo,Maria Isabel N, AU - D'Andrea,Paulo Sérgio, AU - do Val Vilela,Roberto, AU - Lilenbaum,Walter, Y1 - 2019/04/11/ PY - 2018/07/17/received PY - 2019/03/20/revised PY - 2019/04/07/accepted PY - 2019/4/21/pubmed PY - 2019/8/17/medline PY - 2019/4/21/entrez KW - Brazil KW - Leptospirosis KW - Molecular diagnosis KW - One health SP - 280 EP - 283 JF - Research in veterinary science JO - Res Vet Sci VL - 124 N2 - Leptospirosis is an important worldwide zoonosis, caused by a bacterium of the genus Leptospira. For a better understanding of the disease, it is relevant the application of the one health concept. The Atlantic Forest is considered a biodiversity hotspot, with a great endemism of species and despite its importance and proximity to urban areas, the potential role of its fauna as carriers of infectious agents is still poorly understood. Although it is well-known that rats and mice are key reservoirs of leptospires, particularly Rattus norvegicus, wild rodents have also been revealed as reservoirs of leptospiral strains. Thus, the purpose of this study was to investigate the role of the sigmodontine rodents from genera Akodon and Oligoryzomys as pathogenic Leptospira carriers in the Atlantic Forest. We studied 52 Akodon spp. and 15 Oligoryzomys spp. from three areas. Overall 30% were PCR-positive for pathogenic Leptospira, 27% (14/52) Akodon spp. and 40% (6/15) Oligoryzomys spp. DNA sequencing of LipL32 gene confirmed nine species as pathogenic Leptospira. This remarkable incidence of leptospiral carriage within wild genera emphasizes the role of these rodents as carriers of leptospires throughout in this environment. SN - 1532-2661 UR - https://www.unboundmedicine.com/medline/citation/31004919/Neotropical_wild_rodents_Akodon_and_Oligoryzomys__Cricetidae:_Sigmodontinae__as_important_carriers_of_pathogenic_renal_Leptospira_in_the_Atlantic_forest_in_Brazil_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0034-5288(18)31367-5 DB - PRIME DP - Unbound Medicine ER -