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Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity.
J Formos Med Assoc. 2019 Aug; 118(8):1218-1224.JF

Abstract

BACKGROUND/PURPOSE

Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA־TGA+/TMA+AG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA+/TMA+AG patients.

METHODS

The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA־TGA+/TMA+AG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA־TGA־TMA־AG patients) or 532 healthy control subjects.

RESULTS

We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCA־TGA+/TMA+AG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCA־TGA+/TMA+AG patients and 476 GPCA־TGA־TMA־AG patients. The 304 GPCA־TGA+/TMA+AG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCA־TGA־TMA־AG patients.

CONCLUSION

The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA+/TMA+AG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCA־TGA+/TMA+AG patients.

Authors+Show Affiliations

Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31005374

Citation

Kuo, Ying-Shiung, et al. "Blood Profile of Atrophic Glossitis Patients With Thyroglobulin Antibody/thyroid Microsomal Antibody Positivity but Without Gastric Parietal Cell Antibody Positivity." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 118, no. 8, 2019, pp. 1218-1224.
Kuo YS, Wu YH, Chang JY, et al. Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity. J Formos Med Assoc. 2019;118(8):1218-1224.
Kuo, Y. S., Wu, Y. H., Chang, J. Y., Wang, Y. P., Wu, Y. C., & Sun, A. (2019). Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 118(8), 1218-1224. https://doi.org/10.1016/j.jfma.2019.04.002
Kuo YS, et al. Blood Profile of Atrophic Glossitis Patients With Thyroglobulin Antibody/thyroid Microsomal Antibody Positivity but Without Gastric Parietal Cell Antibody Positivity. J Formos Med Assoc. 2019;118(8):1218-1224. PubMed PMID: 31005374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity. AU - Kuo,Ying-Shiung, AU - Wu,Yu-Hsueh, AU - Chang,Julia Yu-Fong, AU - Wang,Yi-Ping, AU - Wu,Yang-Che, AU - Sun,Andy, Y1 - 2019/04/17/ PY - 2019/03/27/received PY - 2019/04/02/accepted PY - 2019/4/22/pubmed PY - 2020/1/16/medline PY - 2019/4/22/entrez KW - Atrophic glossitis KW - Folic acid deficiency KW - Hyperhomocysteinemia KW - Iron deficiency KW - Thyroglobulin antibody KW - Thyroid microsomal antibody SP - 1218 EP - 1224 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 118 IS - 8 N2 - BACKGROUND/PURPOSE: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA־TGA+/TMA+AG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA+/TMA+AG patients. METHODS: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA־TGA+/TMA+AG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA־TGA־TMA־AG patients) or 532 healthy control subjects. RESULTS: We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCA־TGA+/TMA+AG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCA־TGA+/TMA+AG patients and 476 GPCA־TGA־TMA־AG patients. The 304 GPCA־TGA+/TMA+AG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCA־TGA־TMA־AG patients. CONCLUSION: The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA+/TMA+AG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCA־TGA+/TMA+AG patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/31005374/Blood_profile_of_atrophic_glossitis_patients_with_thyroglobulin_antibody/thyroid_microsomal_antibody_positivity_but_without_gastric_parietal_cell_antibody_positivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(19)30268-2 DB - PRIME DP - Unbound Medicine ER -