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Antiviral Activities of Silymarin and Derivatives.
Molecules. 2019 Apr 19; 24(8)M

Abstract

Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.

Authors+Show Affiliations

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. julia.chliu@gmail.com. Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada. julia.chliu@gmail.com.International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. alagie_jassey@yahoo.com.Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. jg930727@gmail.com.Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. ltlin@tmu.edu.tw. Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. ltlin@tmu.edu.tw.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31010179

Citation

Liu, Ching-Hsuan, et al. "Antiviral Activities of Silymarin and Derivatives." Molecules (Basel, Switzerland), vol. 24, no. 8, 2019.
Liu CH, Jassey A, Hsu HY, et al. Antiviral Activities of Silymarin and Derivatives. Molecules. 2019;24(8).
Liu, C. H., Jassey, A., Hsu, H. Y., & Lin, L. T. (2019). Antiviral Activities of Silymarin and Derivatives. Molecules (Basel, Switzerland), 24(8). https://doi.org/10.3390/molecules24081552
Liu CH, et al. Antiviral Activities of Silymarin and Derivatives. Molecules. 2019 Apr 19;24(8) PubMed PMID: 31010179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiviral Activities of Silymarin and Derivatives. AU - Liu,Ching-Hsuan, AU - Jassey,Alagie, AU - Hsu,Hsin-Ya, AU - Lin,Liang-Tzung, Y1 - 2019/04/19/ PY - 2019/03/31/received PY - 2019/04/16/revised PY - 2019/04/17/accepted PY - 2019/4/24/entrez PY - 2019/4/24/pubmed PY - 2019/8/7/medline KW - antiviral KW - drug development KW - flavonolignans KW - silymarin JF - Molecules (Basel, Switzerland) JO - Molecules VL - 24 IS - 8 N2 - Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/31010179/Antiviral_Activities_of_Silymarin_and_Derivatives_ L2 - http://www.mdpi.com/resolver?pii=molecules24081552 DB - PRIME DP - Unbound Medicine ER -