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Necrobiotic xanthogranuloma with paraproteinemia. Case report and a pathogenetic theory.
Ophthalmology 1986; 93(9):1233-6O

Abstract

Necrobiotic xanthogranuloma with paraproteinemia is a clinical and histopathological entity characterized by xanthelasma-like lesions in the periorbital region and elsewhere, paraproteinemia, leukopenia, and an elevated erythrocyte sedimentation rate. Multiple myeloma has been reported as an accompanying feature in several cases. We examined a patient with necrobiotic xanthogranuloma and multiple myeloma in whom an IgG kappa monoclonal protein was identified in serum, urine, bone marrow, and bilateral periorbital lesions. We speculate that increased serum immunoglobulins complexed with lipid may be deposited in the skin, leading to a foreign body giant cell reaction and the subsequent characteristic histopathologic features of necrobiotic xanthogranuloma.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3101022

Citation

Bullock, J D., et al. "Necrobiotic Xanthogranuloma With Paraproteinemia. Case Report and a Pathogenetic Theory." Ophthalmology, vol. 93, no. 9, 1986, pp. 1233-6.
Bullock JD, Bartley GB, Campbell RJ, et al. Necrobiotic xanthogranuloma with paraproteinemia. Case report and a pathogenetic theory. Ophthalmology. 1986;93(9):1233-6.
Bullock, J. D., Bartley, G. B., Campbell, R. J., Yanes, B., Connelly, P. J., & Funkhouser, J. W. (1986). Necrobiotic xanthogranuloma with paraproteinemia. Case report and a pathogenetic theory. Ophthalmology, 93(9), pp. 1233-6.
Bullock JD, et al. Necrobiotic Xanthogranuloma With Paraproteinemia. Case Report and a Pathogenetic Theory. Ophthalmology. 1986;93(9):1233-6. PubMed PMID: 3101022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrobiotic xanthogranuloma with paraproteinemia. Case report and a pathogenetic theory. AU - Bullock,J D, AU - Bartley,G B, AU - Campbell,R J, AU - Yanes,B, AU - Connelly,P J, AU - Funkhouser,J W, PY - 1986/9/1/pubmed PY - 1986/9/1/medline PY - 1986/9/1/entrez SP - 1233 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 93 IS - 9 N2 - Necrobiotic xanthogranuloma with paraproteinemia is a clinical and histopathological entity characterized by xanthelasma-like lesions in the periorbital region and elsewhere, paraproteinemia, leukopenia, and an elevated erythrocyte sedimentation rate. Multiple myeloma has been reported as an accompanying feature in several cases. We examined a patient with necrobiotic xanthogranuloma and multiple myeloma in whom an IgG kappa monoclonal protein was identified in serum, urine, bone marrow, and bilateral periorbital lesions. We speculate that increased serum immunoglobulins complexed with lipid may be deposited in the skin, leading to a foreign body giant cell reaction and the subsequent characteristic histopathologic features of necrobiotic xanthogranuloma. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/3101022/Necrobiotic_xanthogranuloma_with_paraproteinemia__Case_report_and_a_pathogenetic_theory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(86)33605-4 DB - PRIME DP - Unbound Medicine ER -