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Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials.
Molecules. 2019 Apr 12; 24(8)M

Abstract

Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa. CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti-seizure, antipsychotic, neuroprotective, antidepressant and anxiolytic. The neuroprotective activity appears linked to its excellent anti-inflammatory and antioxidant properties. The purpose of this paper is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy. The results of scientific studies obtained so far the use of CBD in clinical applications could represent hope for patients who are resistant to all conventional anti-epileptic drugs.

Authors+Show Affiliations

IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. silvestro9110@gmail.com.IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. santa.mammana@irccsme.it.IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. eugenio.cavalli@irccsme.it.IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. placido.bramanti@irccsme.it.IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. emanuela.mazzon@irccsme.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31013866

Citation

Silvestro, Serena, et al. "Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials." Molecules (Basel, Switzerland), vol. 24, no. 8, 2019.
Silvestro S, Mammana S, Cavalli E, et al. Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials. Molecules. 2019;24(8).
Silvestro, S., Mammana, S., Cavalli, E., Bramanti, P., & Mazzon, E. (2019). Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials. Molecules (Basel, Switzerland), 24(8). https://doi.org/10.3390/molecules24081459
Silvestro S, et al. Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials. Molecules. 2019 Apr 12;24(8) PubMed PMID: 31013866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials. AU - Silvestro,Serena, AU - Mammana,Santa, AU - Cavalli,Eugenio, AU - Bramanti,Placido, AU - Mazzon,Emanuela, Y1 - 2019/04/12/ PY - 2019/03/20/received PY - 2019/04/11/revised PY - 2019/04/11/accepted PY - 2019/4/25/entrez PY - 2019/4/25/pubmed PY - 2019/8/15/medline KW - cannabidiol KW - clinical trials KW - treatment-resistant epilepsy JF - Molecules (Basel, Switzerland) JO - Molecules VL - 24 IS - 8 N2 - Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa. CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti-seizure, antipsychotic, neuroprotective, antidepressant and anxiolytic. The neuroprotective activity appears linked to its excellent anti-inflammatory and antioxidant properties. The purpose of this paper is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy. The results of scientific studies obtained so far the use of CBD in clinical applications could represent hope for patients who are resistant to all conventional anti-epileptic drugs. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/31013866/Use_of_Cannabidiol_in_the_Treatment_of_Epilepsy:_Efficacy_and_Security_in_Clinical_Trials_ L2 - https://www.mdpi.com/resolver?pii=molecules24081459 DB - PRIME DP - Unbound Medicine ER -