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Evaluation of activity of fenbendazole, oxibendazole, piperazine , and pyrantel pamoate alone and combinations against ascarids, strongyles, and strongyloides in horse foals in field tests on two farms in Central Kentucky in 2014 and 2015.
Vet Parasitol Reg Stud Reports. 2016 Jun; 3-4:23-26.VP

Abstract

Activity of fenbendazole (FBZ), oxibendazole (OBZ), piperazine (PIP) and pyrantel pamoate (PRT) alone and combinations of OBZ and PIP and of OBZ and PRT was evaluated against parascarids, strongyles and strongyloides in horse foals (n=281).This was on two farms - Farm A - mixed light-horses (n=26) and Farm B-Thoroughbreds (n=255) - in Central Kentucky in field tests in 2014 and 2015. Foals on both farms were treated one to three times each; an exception was that seven foals on Farm A were nontreated controls. Before treatment, the foals on Farm A were all weighed on scales but weights for Farm B were estimated. Evaluation of the anthelmintics was by recording the number of foals passing specific types of nematode eggs before and after treatment using qualitative and/or quantitative (EPG) methods. Results are: 1) ascarids (parascarids) - efficacy was excellent for OBZ, PIP, OBZ-PIP, and OBZ-PRT; likewise for PRT for one group (in 2014) of Farm A foals but not another group (2015) there. FBZ was inactive against these parasites. 2) strongyles - activity was lacking or incomplete for all of the compounds alone or in combination; it was the best for OBZ-PIP, OBZ-PRT and PRT alone. 3) strongyloides - data indicated no or incomplete activity; it was highest for OBZ and OBZ-PIP. The level of drug activity against parasites in Farm B foals may in some instances have been different if exact rather than estimated body weights had been obtained before treatment like for Farm A foals.

Authors+Show Affiliations

Department of Veterinary Science, University of Kentucky, Gluck Equine Research Center, Lexington, KY 40546-0099, USA. Electronic address: elyons1@uky.edu.Private Equine Veterinary Practitioner, Versailles, KY, USA.Department of Veterinary Science, University of Kentucky, Gluck Equine Research Center, Lexington, KY 40546-0099, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31014495

Citation

Lyons, Eugene T., et al. "Evaluation of Activity of Fenbendazole, Oxibendazole, Piperazine , and Pyrantel Pamoate Alone and Combinations Against Ascarids, Strongyles, and Strongyloides in Horse Foals in Field Tests On Two Farms in Central Kentucky in 2014 and 2015." Veterinary Parasitology, Regional Studies and Reports, vol. 3-4, 2016, pp. 23-26.
Lyons ET, Dorton AR, Tolliver SC. Evaluation of activity of fenbendazole, oxibendazole, piperazine , and pyrantel pamoate alone and combinations against ascarids, strongyles, and strongyloides in horse foals in field tests on two farms in Central Kentucky in 2014 and 2015. Vet Parasitol Reg Stud Reports. 2016;3-4:23-26.
Lyons, E. T., Dorton, A. R., & Tolliver, S. C. (2016). Evaluation of activity of fenbendazole, oxibendazole, piperazine , and pyrantel pamoate alone and combinations against ascarids, strongyles, and strongyloides in horse foals in field tests on two farms in Central Kentucky in 2014 and 2015. Veterinary Parasitology, Regional Studies and Reports, 3-4, 23-26. https://doi.org/10.1016/j.vprsr.2016.05.007
Lyons ET, Dorton AR, Tolliver SC. Evaluation of Activity of Fenbendazole, Oxibendazole, Piperazine , and Pyrantel Pamoate Alone and Combinations Against Ascarids, Strongyles, and Strongyloides in Horse Foals in Field Tests On Two Farms in Central Kentucky in 2014 and 2015. Vet Parasitol Reg Stud Reports. 2016;3-4:23-26. PubMed PMID: 31014495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of activity of fenbendazole, oxibendazole, piperazine , and pyrantel pamoate alone and combinations against ascarids, strongyles, and strongyloides in horse foals in field tests on two farms in Central Kentucky in 2014 and 2015. AU - Lyons,Eugene T, AU - Dorton,Alan R, AU - Tolliver,Sharon C, Y1 - 2016/05/24/ PY - 2016/01/19/received PY - 2016/04/18/revised PY - 2016/05/21/accepted PY - 2019/4/25/entrez PY - 2016/6/1/pubmed PY - 2016/6/1/medline KW - Anthelmintics KW - Ascarids KW - Efficacy KW - Field studies KW - Horse foals KW - Strongyles KW - Strongyloides SP - 23 EP - 26 JF - Veterinary parasitology, regional studies and reports JO - Vet Parasitol Reg Stud Reports VL - 3-4 N2 - Activity of fenbendazole (FBZ), oxibendazole (OBZ), piperazine (PIP) and pyrantel pamoate (PRT) alone and combinations of OBZ and PIP and of OBZ and PRT was evaluated against parascarids, strongyles and strongyloides in horse foals (n=281).This was on two farms - Farm A - mixed light-horses (n=26) and Farm B-Thoroughbreds (n=255) - in Central Kentucky in field tests in 2014 and 2015. Foals on both farms were treated one to three times each; an exception was that seven foals on Farm A were nontreated controls. Before treatment, the foals on Farm A were all weighed on scales but weights for Farm B were estimated. Evaluation of the anthelmintics was by recording the number of foals passing specific types of nematode eggs before and after treatment using qualitative and/or quantitative (EPG) methods. Results are: 1) ascarids (parascarids) - efficacy was excellent for OBZ, PIP, OBZ-PIP, and OBZ-PRT; likewise for PRT for one group (in 2014) of Farm A foals but not another group (2015) there. FBZ was inactive against these parasites. 2) strongyles - activity was lacking or incomplete for all of the compounds alone or in combination; it was the best for OBZ-PIP, OBZ-PRT and PRT alone. 3) strongyloides - data indicated no or incomplete activity; it was highest for OBZ and OBZ-PIP. The level of drug activity against parasites in Farm B foals may in some instances have been different if exact rather than estimated body weights had been obtained before treatment like for Farm A foals. SN - 2405-9390 UR - https://www.unboundmedicine.com/medline/citation/31014495/Evaluation_of_activity_of_fenbendazole_oxibendazole_piperazine__and_pyrantel_pamoate_alone_and_combinations_against_ascarids_strongyles_and_strongyloides_in_horse_foals_in_field_tests_on_two_farms_in_Central_Kentucky_in_2014_and_2015_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-9390(16)30008-9 DB - PRIME DP - Unbound Medicine ER -
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