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Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration.
J Ophthalmol. 2019; 2019:5743109.JO

Abstract

Retinal degenerative diseases are a leading cause of visual impairment or blindness. There are many therapies for delaying the progression of vision loss but no curative strategies currently. Stimulating intrinsic neuronal regeneration is a potential approach to therapy in retinal degenerative diseases. In contrast to stem cells, as embryonic/pluripotent stem cell-derived retinal progenitor cell or mesenchymal stem cells, Müller glia provided an endogenous cellular source for regenerative therapy in the retina. Müller glia are a major component of the retina and considerable evidence suggested these cells can be induced to produce the lost neurons in several species. Understanding the specific characteristic of Müller glia to generate lost neurons will inspire an attractive and alternative therapeutic strategy for treating visual impairment with regenerative research. This review briefly provides the different signal transduction mechanisms which are underlying Müller cell-mediated neuroprotection and neuron regeneration and discusses recent advances about regeneration from Müller glia-derived progenitors.

Authors+Show Affiliations

Eye Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, Jilin 130021, China.Eye Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, Jilin 130021, China.Eye Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, Jilin 130021, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31016037

Citation

Liu, Yang, et al. "Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration." Journal of Ophthalmology, vol. 2019, 2019, p. 5743109.
Liu Y, Wang C, Su G. Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration. J Ophthalmol. 2019;2019:5743109.
Liu, Y., Wang, C., & Su, G. (2019). Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration. Journal of Ophthalmology, 2019, 5743109. https://doi.org/10.1155/2019/5743109
Liu Y, Wang C, Su G. Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration. J Ophthalmol. 2019;2019:5743109. PubMed PMID: 31016037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration. AU - Liu,Yang, AU - Wang,Chenguang, AU - Su,Guanfang, Y1 - 2019/03/19/ PY - 2018/11/30/received PY - 2019/02/28/accepted PY - 2019/4/25/entrez PY - 2019/4/25/pubmed PY - 2019/4/25/medline SP - 5743109 EP - 5743109 JF - Journal of ophthalmology JO - J Ophthalmol VL - 2019 N2 - Retinal degenerative diseases are a leading cause of visual impairment or blindness. There are many therapies for delaying the progression of vision loss but no curative strategies currently. Stimulating intrinsic neuronal regeneration is a potential approach to therapy in retinal degenerative diseases. In contrast to stem cells, as embryonic/pluripotent stem cell-derived retinal progenitor cell or mesenchymal stem cells, Müller glia provided an endogenous cellular source for regenerative therapy in the retina. Müller glia are a major component of the retina and considerable evidence suggested these cells can be induced to produce the lost neurons in several species. Understanding the specific characteristic of Müller glia to generate lost neurons will inspire an attractive and alternative therapeutic strategy for treating visual impairment with regenerative research. This review briefly provides the different signal transduction mechanisms which are underlying Müller cell-mediated neuroprotection and neuron regeneration and discusses recent advances about regeneration from Müller glia-derived progenitors. SN - 2090-004X UR - https://www.unboundmedicine.com/medline/citation/31016037/Cellular_Signaling_in_Müller_Glia:_Progenitor_Cells_for_Regenerative_and_Neuroprotective_Responses_in_Pharmacological_Models_of_Retinal_Degeneration_ L2 - https://doi.org/10.1155/2019/5743109 DB - PRIME DP - Unbound Medicine ER -
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