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Angiocentric astrocytoma in a cat.
J Vet Diagn Invest 2019; 31(4):576-580JV

Abstract

Gliomas are common primary central nervous system neoplasms of dogs and cats, but atypical glioma subtypes are rare. Herein we report an angiocentric astrocytoma in a 15-y-old spayed female domestic shorthaired cat that was euthanized after therapy-resistant seizures. Gross anatomic changes consisted of swelling of the rostral leptomeninges over the olfactory bulbs and rostral telencephalon. Histologically, polygonal-to-elongate atypical neoplastic cells were arranged along perivascular spaces within these areas. Neoplastic cells were positive for glial fibrillary acidic protein, S100 protein, and vimentin. Ultrastructurally, round-to-elongate neoplastic cells emitting long processes with aggregates of intermediary filaments expanded and occupied the spaces between the vascular basement membrane and the glia limitans; nuclei had marginal and central heterochromatin. Tight junctions connected the plasma membrane of neighboring cells. The cell morphology, immunohistochemistry, and ultrastructural findings were consistent with an astrocytoma; the exclusive perivascular arrangement of neoplastic cells with no parenchymal mass warranted the diagnosis of angiocentric astrocytoma.

Authors+Show Affiliations

Department of Pathology (Rissi, McHale), University of Georgia College of Veterinary Medicine, Athens, GA. Athens Veterinary Diagnostic Laboratory (Rissi), University of Georgia College of Veterinary Medicine, Athens, GA. Veterinary Diagnostic Laboratory, Department of Veterinary Population Medicine, University of Minnesota College of Veterinary Medicine, St. Paul, MN (Armién).Department of Pathology (Rissi, McHale), University of Georgia College of Veterinary Medicine, Athens, GA. Athens Veterinary Diagnostic Laboratory (Rissi), University of Georgia College of Veterinary Medicine, Athens, GA. Veterinary Diagnostic Laboratory, Department of Veterinary Population Medicine, University of Minnesota College of Veterinary Medicine, St. Paul, MN (Armién).Department of Pathology (Rissi, McHale), University of Georgia College of Veterinary Medicine, Athens, GA. Athens Veterinary Diagnostic Laboratory (Rissi), University of Georgia College of Veterinary Medicine, Athens, GA. Veterinary Diagnostic Laboratory, Department of Veterinary Population Medicine, University of Minnesota College of Veterinary Medicine, St. Paul, MN (Armién).

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31018782

Citation

Rissi, Daniel R., et al. "Angiocentric Astrocytoma in a Cat." Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, vol. 31, no. 4, 2019, pp. 576-580.
Rissi DR, McHale BJ, Armién AG. Angiocentric astrocytoma in a cat. J Vet Diagn Invest. 2019;31(4):576-580.
Rissi, D. R., McHale, B. J., & Armién, A. G. (2019). Angiocentric astrocytoma in a cat. Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 31(4), pp. 576-580. doi:10.1177/1040638719847239.
Rissi DR, McHale BJ, Armién AG. Angiocentric Astrocytoma in a Cat. J Vet Diagn Invest. 2019;31(4):576-580. PubMed PMID: 31018782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiocentric astrocytoma in a cat. AU - Rissi,Daniel R, AU - McHale,Brittany J, AU - Armién,Anibal G, Y1 - 2019/04/25/ PY - 2020/04/25/pmc-release PY - 2019/4/26/pubmed PY - 2019/10/16/medline PY - 2019/4/26/entrez KW - astrocytoma KW - cats KW - glioma KW - immunohistochemistry KW - neuropathology SP - 576 EP - 580 JF - Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc JO - J. Vet. Diagn. Invest. VL - 31 IS - 4 N2 - Gliomas are common primary central nervous system neoplasms of dogs and cats, but atypical glioma subtypes are rare. Herein we report an angiocentric astrocytoma in a 15-y-old spayed female domestic shorthaired cat that was euthanized after therapy-resistant seizures. Gross anatomic changes consisted of swelling of the rostral leptomeninges over the olfactory bulbs and rostral telencephalon. Histologically, polygonal-to-elongate atypical neoplastic cells were arranged along perivascular spaces within these areas. Neoplastic cells were positive for glial fibrillary acidic protein, S100 protein, and vimentin. Ultrastructurally, round-to-elongate neoplastic cells emitting long processes with aggregates of intermediary filaments expanded and occupied the spaces between the vascular basement membrane and the glia limitans; nuclei had marginal and central heterochromatin. Tight junctions connected the plasma membrane of neighboring cells. The cell morphology, immunohistochemistry, and ultrastructural findings were consistent with an astrocytoma; the exclusive perivascular arrangement of neoplastic cells with no parenchymal mass warranted the diagnosis of angiocentric astrocytoma. SN - 1943-4936 UR - https://www.unboundmedicine.com/medline/citation/31018782/Angiocentric_astrocytoma_in_a_cat L2 - http://journals.sagepub.com/doi/full/10.1177/1040638719847239?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -