Tags

Type your tag names separated by a space and hit enter

The effect of deliberate omission of Trinordiol or Microgynon on the hypothalamo-pituitary-ovarian axis.
Contraception. 1986 Nov; 34(5):513-22.C

Abstract

The effect of deliberate omission of a phased formulation pill, Trinordiol (ethinyl estradiol 30 micrograms + levonorgestrel 50 micrograms: 6 tablets; ethinyl estradiol 40 micrograms + levonorgestrel 75 micrograms: 5 tablets; ethinyl estradiol 30 micrograms + levonorgestrel 125 micrograms: 10 tablets) or a low-dose, combined, oral contraceptive pill, Microgynon (ethinyl estradiol 30 micrograms + levonorgestrel 150 micrograms: 21 tablets) on the hypothalamo-pituitary-ovarian axis were studied. Thirty-six women were recruited to the study and divided equally between the two types of pill. Medication was begun on the 8th pill-free day of the cycle and continued for 7 days (Group 1), 14 days (Group 2) or 21 days (Group 3). Levels of FSH, LH, estradiol (E2) and progesterone (P) were measured in plasma on alternate days during the final week of pill therapy, and daily for the 7 days after stopping the pill. For the first 2 weeks of pill therapy, follicular activity, as judged by plasma levels of E2, was greater in women taking Trinordiol than in those taking Microgynon, but was similar in both groups by the third week of pill treatment. Five women taking Trinordiol (2 in Group 1 and 3 in Group 2) had plasma levels of E2 in excess of 500 pmol/l whilst taking the pills, and only 1 patient achieved this degree of follicular activity after stopping the tablets. One woman who had taken 7 days of Trinordiol (Group 1) showed a rise of plasma levels of P to 6.8 nmol/l, but luteinization did not occur in any of the remaining 35 women who took Trinordiol or Microgynon. These findings suggest that follicular activity is less completely suppressed by Trinordiol than Microgynon, at least in the first 2 weeks of pill therapy, but that normal ovulation is still a rare event in the week after cessation of either of these pills, even if only 7 days of medication have been taken.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3102162

Citation

Smith, S K., et al. "The Effect of Deliberate Omission of Trinordiol or Microgynon On the Hypothalamo-pituitary-ovarian Axis." Contraception, vol. 34, no. 5, 1986, pp. 513-22.
Smith SK, Kirkman RJ, Arce BB, et al. The effect of deliberate omission of Trinordiol or Microgynon on the hypothalamo-pituitary-ovarian axis. Contraception. 1986;34(5):513-22.
Smith, S. K., Kirkman, R. J., Arce, B. B., McNeilly, A. S., Loudon, N. B., & Baird, D. T. (1986). The effect of deliberate omission of Trinordiol or Microgynon on the hypothalamo-pituitary-ovarian axis. Contraception, 34(5), 513-22.
Smith SK, et al. The Effect of Deliberate Omission of Trinordiol or Microgynon On the Hypothalamo-pituitary-ovarian Axis. Contraception. 1986;34(5):513-22. PubMed PMID: 3102162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of deliberate omission of Trinordiol or Microgynon on the hypothalamo-pituitary-ovarian axis. AU - Smith,S K, AU - Kirkman,R J, AU - Arce,B B, AU - McNeilly,A S, AU - Loudon,N B, AU - Baird,D T, PY - 1986/11/1/pubmed PY - 1986/11/1/medline PY - 1986/11/1/entrez KW - Biology KW - Clinical Research KW - Contraception--pharmacodynamics KW - Contraceptive Agents, Estrogen--pharmacodynamics KW - Contraceptive Agents, Female--pharmacodynamics KW - Contraceptive Agents, Progestin--pharmacodynamics KW - Contraceptive Agents--pharmacodynamics KW - Contraceptive Effectiveness KW - Contraceptive Methods--pharmacodynamics KW - Contraceptive Mode Of Action KW - Corpus Luteum Hormones KW - Developed Countries KW - Endocrine System KW - England KW - Estradiol KW - Estrogens KW - Ethinyl Estradiol--pharmacodynamics KW - Europe KW - Family Planning KW - Follicle Stimulating Hormone KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones--pharmacodynamics KW - Levonorgestrel--pharmacodynamics KW - Luteinizing Hormone KW - Northern Europe KW - Oral Contraceptives, Combined--pharmacodynamics KW - Oral Contraceptives, Low-dose--pharmacodynamics KW - Oral Contraceptives, Phasic--pharmacodynamics KW - Oral Contraceptives--pharmacodynamics KW - Ovulation KW - Ovulation Suppression KW - Physiology KW - Progesterone KW - Reproduction KW - Reproductive Control Agents KW - Research Methodology KW - Research Report KW - United Kingdom KW - Use-effectiveness SP - 513 EP - 22 JF - Contraception JO - Contraception VL - 34 IS - 5 N2 - The effect of deliberate omission of a phased formulation pill, Trinordiol (ethinyl estradiol 30 micrograms + levonorgestrel 50 micrograms: 6 tablets; ethinyl estradiol 40 micrograms + levonorgestrel 75 micrograms: 5 tablets; ethinyl estradiol 30 micrograms + levonorgestrel 125 micrograms: 10 tablets) or a low-dose, combined, oral contraceptive pill, Microgynon (ethinyl estradiol 30 micrograms + levonorgestrel 150 micrograms: 21 tablets) on the hypothalamo-pituitary-ovarian axis were studied. Thirty-six women were recruited to the study and divided equally between the two types of pill. Medication was begun on the 8th pill-free day of the cycle and continued for 7 days (Group 1), 14 days (Group 2) or 21 days (Group 3). Levels of FSH, LH, estradiol (E2) and progesterone (P) were measured in plasma on alternate days during the final week of pill therapy, and daily for the 7 days after stopping the pill. For the first 2 weeks of pill therapy, follicular activity, as judged by plasma levels of E2, was greater in women taking Trinordiol than in those taking Microgynon, but was similar in both groups by the third week of pill treatment. Five women taking Trinordiol (2 in Group 1 and 3 in Group 2) had plasma levels of E2 in excess of 500 pmol/l whilst taking the pills, and only 1 patient achieved this degree of follicular activity after stopping the tablets. One woman who had taken 7 days of Trinordiol (Group 1) showed a rise of plasma levels of P to 6.8 nmol/l, but luteinization did not occur in any of the remaining 35 women who took Trinordiol or Microgynon. These findings suggest that follicular activity is less completely suppressed by Trinordiol than Microgynon, at least in the first 2 weeks of pill therapy, but that normal ovulation is still a rare event in the week after cessation of either of these pills, even if only 7 days of medication have been taken. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/3102162/The_effect_of_deliberate_omission_of_Trinordiol_or_Microgynon_on_the_hypothalamo_pituitary_ovarian_axis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(86)90060-0 DB - PRIME DP - Unbound Medicine ER -