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Precision Nutrition and the Microbiome, Part I: Current State of the Science.
Nutrients 2019; 11(4)N

Abstract

The gut microbiota is a highly complex community which evolves and adapts to its host over a lifetime. It has been described as a virtual organ owing to the myriad of functions it performs, including the production of bioactive metabolites, regulation of immunity, energy homeostasis and protection against pathogens. These activities are dependent on the quantity and quality of the microbiota alongside its metabolic potential, which are dictated by a number of factors, including diet and host genetics. In this regard, the gut microbiome is malleable and varies significantly from host to host. These two features render the gut microbiome a candidate 'organ' for the possibility of precision microbiomics - the use of the gut microbiome as a biomarker to predict responsiveness to specific dietary constituents to generate precision diets and interventions for optimal health. With this in mind, this two-part review investigates the current state of the science in terms of the influence of diet and specific dietary components on the gut microbiota and subsequent consequences for health status, along with opportunities to modulate the microbiota for improved health and the potential of the microbiome as a biomarker to predict responsiveness to dietary components. In particular, in Part I, we examine the development of the microbiota from birth and its role in health. We investigate the consequences of poor-quality diet in relation to infection and inflammation and discuss diet-derived microbial metabolites which negatively impact health. We look at the role of diet in shaping the microbiome and the influence of specific dietary components, namely protein, fat and carbohydrates, on gut microbiota composition.

Authors+Show Affiliations

APC Microbiome Ireland, University College Cork, Cork T12 K8AF, Ireland. susan.mills@ucc.ie.APC Microbiome Ireland, Teagasc Food Research Centre, Fermoy P61 C996, Co Cork, Ireland. catherine.stanton@teagasc.ie.H&H Group, Technical Centre, Global Research and Technology Centre, Cork P61 C996, Ireland. jonathan@hh.global.H&H Group, Technical Centre, Global Research and Technology Centre, Cork P61 C996, Ireland. graeme.smith@hh.global.APC Microbiome Ireland, University College Cork, Cork T12 K8AF, Ireland. p.ross@ucc.ie.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31022973

Citation

Mills, Susan, et al. "Precision Nutrition and the Microbiome, Part I: Current State of the Science." Nutrients, vol. 11, no. 4, 2019.
Mills S, Stanton C, Lane JA, et al. Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients. 2019;11(4).
Mills, S., Stanton, C., Lane, J. A., Smith, G. J., & Ross, R. P. (2019). Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients, 11(4), doi:10.3390/nu11040923.
Mills S, et al. Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients. 2019 Apr 24;11(4) PubMed PMID: 31022973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Precision Nutrition and the Microbiome, Part I: Current State of the Science. AU - Mills,Susan, AU - Stanton,Catherine, AU - Lane,Jonathan A, AU - Smith,Graeme J, AU - Ross,R Paul, Y1 - 2019/04/24/ PY - 2019/03/21/received PY - 2019/04/10/revised PY - 2019/04/17/accepted PY - 2019/4/27/entrez PY - 2019/4/27/pubmed PY - 2019/4/27/medline KW - genetics KW - gut KW - gut microbiome KW - immunity KW - metabolic disease KW - personalised nutrition KW - prebiotics KW - precision nutrition KW - probiotics JF - Nutrients JO - Nutrients VL - 11 IS - 4 N2 - The gut microbiota is a highly complex community which evolves and adapts to its host over a lifetime. It has been described as a virtual organ owing to the myriad of functions it performs, including the production of bioactive metabolites, regulation of immunity, energy homeostasis and protection against pathogens. These activities are dependent on the quantity and quality of the microbiota alongside its metabolic potential, which are dictated by a number of factors, including diet and host genetics. In this regard, the gut microbiome is malleable and varies significantly from host to host. These two features render the gut microbiome a candidate 'organ' for the possibility of precision microbiomics - the use of the gut microbiome as a biomarker to predict responsiveness to specific dietary constituents to generate precision diets and interventions for optimal health. With this in mind, this two-part review investigates the current state of the science in terms of the influence of diet and specific dietary components on the gut microbiota and subsequent consequences for health status, along with opportunities to modulate the microbiota for improved health and the potential of the microbiome as a biomarker to predict responsiveness to dietary components. In particular, in Part I, we examine the development of the microbiota from birth and its role in health. We investigate the consequences of poor-quality diet in relation to infection and inflammation and discuss diet-derived microbial metabolites which negatively impact health. We look at the role of diet in shaping the microbiome and the influence of specific dietary components, namely protein, fat and carbohydrates, on gut microbiota composition. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/31022973/Precision_Nutrition_and_the_Microbiome,_Part_I:_Current_State_of_the_Science L2 - http://www.mdpi.com/resolver?pii=nu11040923 DB - PRIME DP - Unbound Medicine ER -