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Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone-induced oxidative injury in mouse testis and sperm parameters.

Abstract

Testicular tissue and sex hormones are sensitive to the anabolic steroids (oxymetholone/OM) due to increased free radical damage and hormonal changes. The Nasturtium officinale L. have various antioxidant compounds. The aim of the present study was to investigate N. officinale effect on OM-induced oxidative injury in mouse testis and sperm parameters. Thirty BALB/c mice were divided into five groups, including control, OM (5 ml/kg) and three N. officinale doses (25, 50 and 100 mg/kg) + OM. At the end of the study (40 days), serum luteinising hormone (LH), follicle-stimulating hormone (FSH), testosterone, nitric oxide (NO) levels, ferric reducing ability of power (FRAP) and testis stereological factors were measured. The sperm parameters were evaluated. Liquid chromatography-electrospray ionisation-tandem mass spectrometry (LC-ESI/MS) analysis was yielded a fingerprint of N. officinale phenolic constituents. 100 mg/kg of N. officinale extract significantly reduced the serum level of testosterone and a significant increase in LH and FSH in comparison with the control group. This dose also significantly improved the stereological factors and sperm parameters. 50 and 100 mg/kg of N. officinale extract significantly increased the testis tissue FRAP levels, and 100 doses reduced the serum levels of NO. Fourteen compounds and 34 peaks were identified in the extract with LC-ESI/MS. Nasturtium officinale extract has protective effects against testicular toxicity caused by OM.

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  • Authors+Show Affiliations

    ,

    Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

    ,

    Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

    ,

    Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

    Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

    Source

    Andrologia 51:7 2019 Aug pg e13294

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31025410

    Citation

    Akbari Bazm, Mohsen, et al. "Nasturtium Officinale L. Hydroalcoholic Extract Improved Oxymetholone-induced Oxidative Injury in Mouse Testis and Sperm Parameters." Andrologia, vol. 51, no. 7, 2019, pp. e13294.
    Akbari Bazm M, Khazaei M, Khazaei F, et al. Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone-induced oxidative injury in mouse testis and sperm parameters. Andrologia. 2019;51(7):e13294.
    Akbari Bazm, M., Khazaei, M., Khazaei, F., & Naseri, L. (2019). Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone-induced oxidative injury in mouse testis and sperm parameters. Andrologia, 51(7), pp. e13294. doi:10.1111/and.13294.
    Akbari Bazm M, et al. Nasturtium Officinale L. Hydroalcoholic Extract Improved Oxymetholone-induced Oxidative Injury in Mouse Testis and Sperm Parameters. Andrologia. 2019;51(7):e13294. PubMed PMID: 31025410.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone-induced oxidative injury in mouse testis and sperm parameters. AU - Akbari Bazm,Mohsen, AU - Khazaei,Mozafar, AU - Khazaei,Fatemeh, AU - Naseri,Leila, Y1 - 2019/04/25/ PY - 2018/11/20/received PY - 2019/03/12/revised PY - 2019/03/26/accepted PY - 2019/4/27/pubmed PY - 2019/4/27/medline PY - 2019/4/27/entrez KW - Nasturtium officinale KW - LC-ESI/MS KW - oxymetholone KW - stereology KW - testis SP - e13294 EP - e13294 JF - Andrologia JO - Andrologia VL - 51 IS - 7 N2 - Testicular tissue and sex hormones are sensitive to the anabolic steroids (oxymetholone/OM) due to increased free radical damage and hormonal changes. The Nasturtium officinale L. have various antioxidant compounds. The aim of the present study was to investigate N. officinale effect on OM-induced oxidative injury in mouse testis and sperm parameters. Thirty BALB/c mice were divided into five groups, including control, OM (5 ml/kg) and three N. officinale doses (25, 50 and 100 mg/kg) + OM. At the end of the study (40 days), serum luteinising hormone (LH), follicle-stimulating hormone (FSH), testosterone, nitric oxide (NO) levels, ferric reducing ability of power (FRAP) and testis stereological factors were measured. The sperm parameters were evaluated. Liquid chromatography-electrospray ionisation-tandem mass spectrometry (LC-ESI/MS) analysis was yielded a fingerprint of N. officinale phenolic constituents. 100 mg/kg of N. officinale extract significantly reduced the serum level of testosterone and a significant increase in LH and FSH in comparison with the control group. This dose also significantly improved the stereological factors and sperm parameters. 50 and 100 mg/kg of N. officinale extract significantly increased the testis tissue FRAP levels, and 100 doses reduced the serum levels of NO. Fourteen compounds and 34 peaks were identified in the extract with LC-ESI/MS. Nasturtium officinale extract has protective effects against testicular toxicity caused by OM. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/31025410/Nasturtium_Officinale_L._hydroalcoholic_extract_improved_oxymetholone-induced_oxidative_injury_in_mouse_testis_and_sperm_parameters L2 - https://doi.org/10.1111/and.13294 DB - PRIME DP - Unbound Medicine ER -