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Tying pest insects in knots: the deployment of spider-venom-derived knottins as bioinsecticides.
Pest Manag Sci. 2019 Sep; 75(9):2437-2445.PM

Abstract

Spider venoms are complex chemical arsenals that contain a rich variety of insecticidal toxins. However, the major toxin class in many spider venoms is disulfide-rich peptides known as knottins. The knotted three-dimensional fold of these mini-proteins provides them with exceptional chemical and thermal stability as well as resistance to proteases. In contrast with other bioinsecticides, which are often slow-acting, spider knottins are fast-acting neurotoxins. In addition to being potently insecticidal, some knottins have exceptional taxonomic selectivity, being lethal to key agricultural pests but innocuous to vertebrates and beneficial insects such as bees. The intrinsic oral activity of these peptides, combined with the ability of aerosolized knottins to penetrate insect spiracles, has enabled them to be developed commercially as eco-friendly bioinsecticides. Moreover, it has been demonstrated that spider-knottin transgenes can be used to engineer faster-acting entomopathogens and insect-resistant crops. © 2019 Society of Chemical Industry.

Authors+Show Affiliations

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31025461

Citation

King, Glenn F.. "Tying Pest Insects in Knots: the Deployment of Spider-venom-derived Knottins as Bioinsecticides." Pest Management Science, vol. 75, no. 9, 2019, pp. 2437-2445.
King GF. Tying pest insects in knots: the deployment of spider-venom-derived knottins as bioinsecticides. Pest Manag Sci. 2019;75(9):2437-2445.
King, G. F. (2019). Tying pest insects in knots: the deployment of spider-venom-derived knottins as bioinsecticides. Pest Management Science, 75(9), 2437-2445. https://doi.org/10.1002/ps.5452
King GF. Tying Pest Insects in Knots: the Deployment of Spider-venom-derived Knottins as Bioinsecticides. Pest Manag Sci. 2019;75(9):2437-2445. PubMed PMID: 31025461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tying pest insects in knots: the deployment of spider-venom-derived knottins as bioinsecticides. A1 - King,Glenn F, Y1 - 2019/05/31/ PY - 2019/02/15/received PY - 2019/04/20/revised PY - 2019/04/25/accepted PY - 2019/4/27/pubmed PY - 2019/11/20/medline PY - 2019/4/27/entrez KW - bioinsecticide KW - entomopathogen KW - knottin peptide KW - spider venom KW - transgenic plant SP - 2437 EP - 2445 JF - Pest management science JO - Pest Manag. Sci. VL - 75 IS - 9 N2 - Spider venoms are complex chemical arsenals that contain a rich variety of insecticidal toxins. However, the major toxin class in many spider venoms is disulfide-rich peptides known as knottins. The knotted three-dimensional fold of these mini-proteins provides them with exceptional chemical and thermal stability as well as resistance to proteases. In contrast with other bioinsecticides, which are often slow-acting, spider knottins are fast-acting neurotoxins. In addition to being potently insecticidal, some knottins have exceptional taxonomic selectivity, being lethal to key agricultural pests but innocuous to vertebrates and beneficial insects such as bees. The intrinsic oral activity of these peptides, combined with the ability of aerosolized knottins to penetrate insect spiracles, has enabled them to be developed commercially as eco-friendly bioinsecticides. Moreover, it has been demonstrated that spider-knottin transgenes can be used to engineer faster-acting entomopathogens and insect-resistant crops. © 2019 Society of Chemical Industry. SN - 1526-4998 UR - https://www.unboundmedicine.com/medline/citation/31025461/Tying_pest_insects_in_knots:_the_deployment_of_spider_venom_derived_knottins_as_bioinsecticides_ L2 - https://doi.org/10.1002/ps.5452 DB - PRIME DP - Unbound Medicine ER -