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Xenobiotics Formed during Food Processing: Their Relation with the Intestinal Microbiota and Colorectal Cancer.
Int J Mol Sci. 2019 Apr 25; 20(8)IJ

Abstract

The colonic epithelium is exposed to a mixture of compounds through diet, among which some are procarcinogens, whereas others have a protective effect. Therefore, the net impact of these compounds on human health depends on the overall balance between all factors involved. Strong scientific evidence has demonstrated the relationship between nitrosamines (NA), heterocyclic amines (HCAs), and polycyclic aromatic hydrocarbons (PAHs), which are the major genotoxins derived from cooking and food processing, and cancer. The mechanisms of the relationship between dietary toxic xenobiotics and cancer risk are not yet well understood, but it has been suggested that differences in dietary habits affect the colonic environment by increasing or decreasing the exposure to mutagens directly and indirectly through changes in the composition and activity of the gut microbiota. Several changes in the proportions of specific microbial groups have been proposed as risk factors for the development of neoplastic lesions and the enrichment of enterotoxigenic microbial strains in stool. In addition, changes in the gut microbiota composition and activity promoted by diet may modify the faecal genotoxicity/cytotoxicity, which can be associated with a higher or lower risk of developing cancer. Therefore, the interaction between dietary components and intestinal bacteria may be a modifiable factor for the development of colorectal cancer in humans and deserves more attention in the near future.

Authors+Show Affiliations

Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n, Villaviciosa, 33300 Asturias, Spain. alicja.nogacka@ipla.csic.es. Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011 Asturias, Spain. alicja.nogacka@ipla.csic.es.Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011 Asturias, Spain. mariagomart@gmail.com. Department of Functional Biology, University of Oviedo, C/Julian Clavería s/n Oviedo, 33006 Asturias, Spain. mariagomart@gmail.com.Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011 Asturias, Spain. adolfo.suarez@hcabuenes.es. Digestive Service, Central University Hospital of Asturias (HUCA), SESPA, Oviedo, 33011 Asturias, Spain. adolfo.suarez@hcabuenes.es.Digestive Service, Central University Hospital of Asturias (HUCA), SESPA, Oviedo, 33011 Asturias, Spain. oscargbernardo@hotmail.com.Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011 Asturias, Spain. greyes_gavilan@ipla.csic.es. Department of Functional Biology, University of Oviedo, C/Julian Clavería s/n Oviedo, 33006 Asturias, Spain. greyes_gavilan@ipla.csic.es.Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n, Villaviciosa, 33300 Asturias, Spain. soniagsolares@uniovi.es. Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011 Asturias, Spain. soniagsolares@uniovi.es.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31027304

Citation

Nogacka, Alicja M., et al. "Xenobiotics Formed During Food Processing: Their Relation With the Intestinal Microbiota and Colorectal Cancer." International Journal of Molecular Sciences, vol. 20, no. 8, 2019.
Nogacka AM, Gómez-Martín M, Suárez A, et al. Xenobiotics Formed during Food Processing: Their Relation with the Intestinal Microbiota and Colorectal Cancer. Int J Mol Sci. 2019;20(8).
Nogacka, A. M., Gómez-Martín, M., Suárez, A., González-Bernardo, O., de Los Reyes-Gavilán, C. G., & González, S. (2019). Xenobiotics Formed during Food Processing: Their Relation with the Intestinal Microbiota and Colorectal Cancer. International Journal of Molecular Sciences, 20(8). https://doi.org/10.3390/ijms20082051
Nogacka AM, et al. Xenobiotics Formed During Food Processing: Their Relation With the Intestinal Microbiota and Colorectal Cancer. Int J Mol Sci. 2019 Apr 25;20(8) PubMed PMID: 31027304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xenobiotics Formed during Food Processing: Their Relation with the Intestinal Microbiota and Colorectal Cancer. AU - Nogacka,Alicja M, AU - Gómez-Martín,María, AU - Suárez,Adolfo, AU - González-Bernardo,Oscar, AU - de Los Reyes-Gavilán,Clara G, AU - González,Sonia, Y1 - 2019/04/25/ PY - 2019/04/05/received PY - 2019/04/20/revised PY - 2019/04/23/accepted PY - 2019/4/28/entrez PY - 2019/4/28/pubmed PY - 2019/8/14/medline KW - aromatic polycyclic hydrocarbons KW - colorectal cancer KW - cooking KW - cytotoxicity KW - diet KW - food processing KW - genotoxicity KW - heterocyclic amines KW - intestinal microbiota KW - xenobiotics JF - International journal of molecular sciences JO - Int J Mol Sci VL - 20 IS - 8 N2 - The colonic epithelium is exposed to a mixture of compounds through diet, among which some are procarcinogens, whereas others have a protective effect. Therefore, the net impact of these compounds on human health depends on the overall balance between all factors involved. Strong scientific evidence has demonstrated the relationship between nitrosamines (NA), heterocyclic amines (HCAs), and polycyclic aromatic hydrocarbons (PAHs), which are the major genotoxins derived from cooking and food processing, and cancer. The mechanisms of the relationship between dietary toxic xenobiotics and cancer risk are not yet well understood, but it has been suggested that differences in dietary habits affect the colonic environment by increasing or decreasing the exposure to mutagens directly and indirectly through changes in the composition and activity of the gut microbiota. Several changes in the proportions of specific microbial groups have been proposed as risk factors for the development of neoplastic lesions and the enrichment of enterotoxigenic microbial strains in stool. In addition, changes in the gut microbiota composition and activity promoted by diet may modify the faecal genotoxicity/cytotoxicity, which can be associated with a higher or lower risk of developing cancer. Therefore, the interaction between dietary components and intestinal bacteria may be a modifiable factor for the development of colorectal cancer in humans and deserves more attention in the near future. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/31027304/full_citation L2 - https://www.mdpi.com/resolver?pii=ijms20082051 DB - PRIME DP - Unbound Medicine ER -