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Distillation of Posterior Fossa Demyelination in Acute Vestibular Syndrome: the Eyes Have It.
Cerebellum 2019; 18(4):673-675C

Abstract

Separating the etiologies of an acute vestibular syndrome (AVS) of central origin is a clinical challenge; the common causes include (1) stroke of the brainstem/cerebellum and (2) demyelinating disorders such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Overshadowed by the vascular etiologies, the literature describing AVS due to demyelinating disorders has been growing through the last decade. The discovery of IgG-NMO, a specific pathogenic antibody directed against the astrocytic water channel aquaporin-4 (AQP4), has improved the differential diagnoses between MS and NMOSD. AQP4 is particularly expressed in ependymal/subependymal astrocytes and glia limitans astrocyte processes, including around the fourth ventricle. Adding a clinical biomarker to distinguish MS and NMOSD in AVS patients, as reported in this issue, will be of great clinical value.

Authors+Show Affiliations

University Hospitals and Cleveland VA Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44110, USA. aasefshaikh@gmail.com.Chef du Service de Neurologie, CHU-Charleroi, Charleroi, Belgium.

Pub Type(s)

Editorial

Language

eng

PubMed ID

31028519

Citation

Shaikh, Aasef G., and Mario Manto. "Distillation of Posterior Fossa Demyelination in Acute Vestibular Syndrome: the Eyes Have It." Cerebellum (London, England), vol. 18, no. 4, 2019, pp. 673-675.
Shaikh AG, Manto M. Distillation of Posterior Fossa Demyelination in Acute Vestibular Syndrome: the Eyes Have It. Cerebellum. 2019;18(4):673-675.
Shaikh, A. G., & Manto, M. (2019). Distillation of Posterior Fossa Demyelination in Acute Vestibular Syndrome: the Eyes Have It. Cerebellum (London, England), 18(4), pp. 673-675. doi:10.1007/s12311-019-01032-6.
Shaikh AG, Manto M. Distillation of Posterior Fossa Demyelination in Acute Vestibular Syndrome: the Eyes Have It. Cerebellum. 2019;18(4):673-675. PubMed PMID: 31028519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distillation of Posterior Fossa Demyelination in Acute Vestibular Syndrome: the Eyes Have It. AU - Shaikh,Aasef G, AU - Manto,Mario, PY - 2019/4/28/pubmed PY - 2020/1/14/medline PY - 2019/4/28/entrez SP - 673 EP - 675 JF - Cerebellum (London, England) JO - Cerebellum VL - 18 IS - 4 N2 - Separating the etiologies of an acute vestibular syndrome (AVS) of central origin is a clinical challenge; the common causes include (1) stroke of the brainstem/cerebellum and (2) demyelinating disorders such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Overshadowed by the vascular etiologies, the literature describing AVS due to demyelinating disorders has been growing through the last decade. The discovery of IgG-NMO, a specific pathogenic antibody directed against the astrocytic water channel aquaporin-4 (AQP4), has improved the differential diagnoses between MS and NMOSD. AQP4 is particularly expressed in ependymal/subependymal astrocytes and glia limitans astrocyte processes, including around the fourth ventricle. Adding a clinical biomarker to distinguish MS and NMOSD in AVS patients, as reported in this issue, will be of great clinical value. SN - 1473-4230 UR - https://www.unboundmedicine.com/medline/citation/31028519/Distillation_of_Posterior_Fossa_Demyelination_in_Acute_Vestibular_Syndrome:_the_Eyes_Have_It L2 - https://dx.doi.org/10.1007/s12311-019-01032-6 DB - PRIME DP - Unbound Medicine ER -