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Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice.
Nutrition. 2019 Jul - Aug; 63-64:184-192.N

Abstract

OBJECTIVE

Aging induces several physiologic and immune changes. The usefulness of probiotics in ameliorating age-related disorders remains largely unexplored. The aim of this study was to evaluate the effectiveness of a Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture in improving the physiologic status and immunity of older adults (over 75 years). Furthermore, the possible role of such mixture in ameliorating gut immunity in aged mice was investigated.

METHODS

A randomized, double-blind, placebo-controlled trial was conducted with 98 adults (84.6 ± 7.8 y), supplemented for 30 d with a biscuit containing a probiotic mixture of B. longum Bar33 and L. helveticus Bar13 (1:1), or no probiotics, as placebo. Blood was collected for analysis of biochemical parameters, lymphocyte subpopulations, natural killer activity, and cytokine release. Aged Balb/c mice received the same probiotic mixture or placebo daily for 28 d, then blood and intestinal lymphocyte subpopulations were analyzed.

RESULTS

The probiotic mixture ameliorated immune response in older adults by increasing naive, activated memory, regulatory T cells, B cells, and natural killer activity and decreasing memory T cells compared with placebo (P < 0.05). The biochemical parameters did not change after probiotic supplementation. In the gut of old mice, the two probiotics modulated cells crucial for gut immune homeostasis by increasing regulatory T (Treg and Tr1) and decreasing γδ T cells compared with control mice (P < 0.05). In addition, B cells increased in the gut and blood of probiotic-treated mice.

CONCLUSION

Results from the present study data indicated that B. longum Bar33 and L. helveticus Bar13 improve immune function at intestinal and peripheral sites in aging.

Authors+Show Affiliations

CREA Research Centre for Food and Nutrition, Rome, Italy. Electronic address: Alberto.finamore@crea.gov.it.CREA Research Centre for Food and Nutrition, Rome, Italy.Sapienza University, Department of Experimental Medicine, Rome, Italy.CREA Research Centre for Food and Nutrition, Rome, Italy.CREA Research Centre for Food and Nutrition, Rome, Italy.R&D Advanced Research Microbiology, Barilla G&R f.lli SpA, Parma, Italy.CREA Research Centre for Food and Nutrition, Rome, Italy.Sapienza University, Department of Experimental Medicine, Rome, Italy.Sapienza University, Department of Experimental Medicine, Rome, Italy.CREA Research Centre for Food and Nutrition, Rome, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31029046

Citation

Finamore, Alberto, et al. "Supplementation With Bifidobacterium Longum Bar33 and Lactobacillus Helveticus Bar13 Mixture Improves Immunity in Elderly Humans (over 75 Years) and Aged Mice." Nutrition (Burbank, Los Angeles County, Calif.), vol. 63-64, 2019, pp. 184-192.
Finamore A, Roselli M, Donini L, et al. Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice. Nutrition. 2019;63-64:184-192.
Finamore, A., Roselli, M., Donini, L., Brasili, D. E., Rami, R., Carnevali, P., Mistura, L., Pinto, A., Giusti, A., & Mengheri, E. (2019). Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice. Nutrition (Burbank, Los Angeles County, Calif.), 63-64, 184-192. https://doi.org/10.1016/j.nut.2019.02.005
Finamore A, et al. Supplementation With Bifidobacterium Longum Bar33 and Lactobacillus Helveticus Bar13 Mixture Improves Immunity in Elderly Humans (over 75 Years) and Aged Mice. Nutrition. 2019 Jul - Aug;63-64:184-192. PubMed PMID: 31029046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice. AU - Finamore,Alberto, AU - Roselli,Marianna, AU - Donini,LorenzoMaria, AU - Brasili,Dr Elisa, AU - Rami,Rita, AU - Carnevali,Paola, AU - Mistura,Lorenza, AU - Pinto,Alessandro, AU - Giusti,AnnaMaria, AU - Mengheri,Elena, Y1 - 2019/02/18/ PY - 2018/11/16/received PY - 2019/01/24/revised PY - 2019/02/14/accepted PY - 2019/4/28/pubmed PY - 2019/4/28/medline PY - 2019/4/28/entrez KW - Aged mice KW - Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture KW - Elderly KW - Immunosenescence KW - Probiotics SP - 184 EP - 192 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 63-64 N2 - OBJECTIVE: Aging induces several physiologic and immune changes. The usefulness of probiotics in ameliorating age-related disorders remains largely unexplored. The aim of this study was to evaluate the effectiveness of a Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture in improving the physiologic status and immunity of older adults (over 75 years). Furthermore, the possible role of such mixture in ameliorating gut immunity in aged mice was investigated. METHODS: A randomized, double-blind, placebo-controlled trial was conducted with 98 adults (84.6 ± 7.8 y), supplemented for 30 d with a biscuit containing a probiotic mixture of B. longum Bar33 and L. helveticus Bar13 (1:1), or no probiotics, as placebo. Blood was collected for analysis of biochemical parameters, lymphocyte subpopulations, natural killer activity, and cytokine release. Aged Balb/c mice received the same probiotic mixture or placebo daily for 28 d, then blood and intestinal lymphocyte subpopulations were analyzed. RESULTS: The probiotic mixture ameliorated immune response in older adults by increasing naive, activated memory, regulatory T cells, B cells, and natural killer activity and decreasing memory T cells compared with placebo (P < 0.05). The biochemical parameters did not change after probiotic supplementation. In the gut of old mice, the two probiotics modulated cells crucial for gut immune homeostasis by increasing regulatory T (Treg and Tr1) and decreasing γδ T cells compared with control mice (P < 0.05). In addition, B cells increased in the gut and blood of probiotic-treated mice. CONCLUSION: Results from the present study data indicated that B. longum Bar33 and L. helveticus Bar13 improve immune function at intestinal and peripheral sites in aging. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/31029046/Supplementation_with_Bifidobacterium_longum_Bar33_and_Lactobacillus_helveticus_Bar13_mixture_improves_immunity_in_elderly_humans_(over_75_years)_and_aged_mice L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(18)31307-8 DB - PRIME DP - Unbound Medicine ER -
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