Tags

Type your tag names separated by a space and hit enter

Effects of psychosensory stimulation on anal pressures: Effects of alfuzosin.
Neurogastroenterol Motil. 2019 07; 31(7):e13618.NM

Abstract

BACKGROUND

Our aim is to explain the lack of clarity in the ways in which anxiety and depression, which are common in defecatory disorders (DD), may contribute to the disorder. In this study, we evaluate the effects of mental stress and relaxation on anal pressures and the mechanisms thereof.

METHODS

In 38 healthy women and 36 DD patients, rectoanal pressures were assessed at rest and during mental stressors (ie, word-color conflict [Stroop] and mental arithmetic tests) and mental relaxation, before and after randomization to placebo or the adrenergic α1 -antagonist alfuzosin.

KEY RESULTS

During the baseline Stroop test, the anal pressure increased by 6 ± 13 mm Hg (mean ± SD, P = 0.004) in healthy women and 9 ± 10 mm Hg (P = 0.0001) in constipated women. During mental arithmetic, the anal pressure increased in healthy (4 ± 8 mm Hg, P = 0.002) and constipated women (5 ± 9 mm Hg, P = 0.004). After relaxation, anal pressure declined (P = 0.0004) by 3 ± 4 mm Hg in DD patients but not in controls. Alfuzosin reduced (P = 0.0001) anal resting pressure (by 31 ± 19 mm Hg) vs placebo (16 ± 18 mm Hg). However, during the postdrug Stroop test, anal pressure increased (P = 0.0001) in participants who received alfuzosin but not placebo.

CONCLUSIONS & INFERENCES

In healthy controls and DD patients, mental stressors likely increased anal pressure by contracting the internal anal sphincter; relaxation reduced anal pressure in DD patients. Alfuzosin reduced anal resting pressure but did not block the Stroop-mediated contractile response, which suggests that this response is not entirely mediated by adrenergic α1 receptors.

Authors+Show Affiliations

Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31032543

Citation

Muthyala, Anjani, et al. "Effects of Psychosensory Stimulation On Anal Pressures: Effects of Alfuzosin." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 31, no. 7, 2019, pp. e13618.
Muthyala A, Feuerhak KJ, Harmsen WS, et al. Effects of psychosensory stimulation on anal pressures: Effects of alfuzosin. Neurogastroenterol Motil. 2019;31(7):e13618.
Muthyala, A., Feuerhak, K. J., Harmsen, W. S., Chakraborty, S., Bailey, K. R., & Bharucha, A. E. (2019). Effects of psychosensory stimulation on anal pressures: Effects of alfuzosin. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 31(7), e13618. https://doi.org/10.1111/nmo.13618
Muthyala A, et al. Effects of Psychosensory Stimulation On Anal Pressures: Effects of Alfuzosin. Neurogastroenterol Motil. 2019;31(7):e13618. PubMed PMID: 31032543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of psychosensory stimulation on anal pressures: Effects of alfuzosin. AU - Muthyala,Anjani, AU - Feuerhak,Kelly J, AU - Harmsen,William S, AU - Chakraborty,Subhankar, AU - Bailey,Kent R, AU - Bharucha,Adil E, Y1 - 2019/04/29/ PY - 2019/03/01/received PY - 2019/04/15/revised PY - 2019/04/17/accepted PY - 2020/07/01/pmc-release PY - 2019/4/30/pubmed PY - 2020/4/10/medline PY - 2019/4/30/entrez KW - Stroop KW - alfuzosin KW - anal pressure KW - constipation KW - mental stressors SP - e13618 EP - e13618 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol. Motil. VL - 31 IS - 7 N2 - BACKGROUND: Our aim is to explain the lack of clarity in the ways in which anxiety and depression, which are common in defecatory disorders (DD), may contribute to the disorder. In this study, we evaluate the effects of mental stress and relaxation on anal pressures and the mechanisms thereof. METHODS: In 38 healthy women and 36 DD patients, rectoanal pressures were assessed at rest and during mental stressors (ie, word-color conflict [Stroop] and mental arithmetic tests) and mental relaxation, before and after randomization to placebo or the adrenergic α1 -antagonist alfuzosin. KEY RESULTS: During the baseline Stroop test, the anal pressure increased by 6 ± 13 mm Hg (mean ± SD, P = 0.004) in healthy women and 9 ± 10 mm Hg (P = 0.0001) in constipated women. During mental arithmetic, the anal pressure increased in healthy (4 ± 8 mm Hg, P = 0.002) and constipated women (5 ± 9 mm Hg, P = 0.004). After relaxation, anal pressure declined (P = 0.0004) by 3 ± 4 mm Hg in DD patients but not in controls. Alfuzosin reduced (P = 0.0001) anal resting pressure (by 31 ± 19 mm Hg) vs placebo (16 ± 18 mm Hg). However, during the postdrug Stroop test, anal pressure increased (P = 0.0001) in participants who received alfuzosin but not placebo. CONCLUSIONS & INFERENCES: In healthy controls and DD patients, mental stressors likely increased anal pressure by contracting the internal anal sphincter; relaxation reduced anal pressure in DD patients. Alfuzosin reduced anal resting pressure but did not block the Stroop-mediated contractile response, which suggests that this response is not entirely mediated by adrenergic α1 receptors. SN - 1365-2982 UR - https://www.unboundmedicine.com/medline/citation/31032543/Effects_of_psychosensory_stimulation_on_anal_pressures:_Effects_of_alfuzosin L2 - https://doi.org/10.1111/nmo.13618 DB - PRIME DP - Unbound Medicine ER -