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Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain).
Future Microbiol. 2019 04; 14:499-507.FM

Abstract

Aim:

To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017-2018 season.

Methods:

Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events.

Results:

An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol.

Conclusion:

The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers.

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Authors+Show Affiliations

Andrés C
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Guasch E
Primary Care Service Muntanya, Institut Català de la Salut, Department of Health, Barcelona, Spain.
Piñana M
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Fernandes P
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Gimferrer L
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Esso DV
Primary Care Service Muntanya, Institut Català de la Salut, Department of Health, Barcelona, Spain.
Codina MG
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Esperalba J
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Vila J
Paediatric Hospitalisation Unit, Department of Paediatrics, Hospital Universitari Maternoinfantil Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Rodrigo C
Paediatric Hospitalisation Unit, Department of Paediatrics, Hospital Universitari Maternoinfantil Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Martín MC
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Fuentes F
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Rubio S
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Pumarola T
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Group for EV Surveillance in Pediatric Primary Care
Primary Care Service Muntanya, Institut Català de la Salut, Department of Health, Barcelona, Spain.
Antón A
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

MeSH

Capsid ProteinsChild, PreschoolDisease OutbreaksEnterovirusEnterovirus InfectionsFemaleGenotypeHand, Foot and Mouth DiseaseHerpanginaHumansInfantMalePhylogenyPrimary Health CareProspective StudiesSpain

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31033351

Citation

Andrés, Cristina, et al. "Recombinant CV-A6 Strains Related to Hand-foot-mouth Disease and Herpangina at Primary Care Centers (Barcelona, Spain)." Future Microbiology, vol. 14, 2019, pp. 499-507.
Andrés C, Guasch E, Piñana M, et al. Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain). Future Microbiol. 2019;14:499-507.
Andrés, C., Guasch, E., Piñana, M., Fernandes, P., Gimferrer, L., Esso, D. V., Codina, M. G., Esperalba, J., Vila, J., Rodrigo, C., Martín, M. C., Fuentes, F., Rubio, S., Pumarola, T., & Antón, A. (2019). Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain). Future Microbiology, 14, 499-507. https://doi.org/10.2217/fmb-2018-0336
Andrés C, et al. Recombinant CV-A6 Strains Related to Hand-foot-mouth Disease and Herpangina at Primary Care Centers (Barcelona, Spain). Future Microbiol. 2019;14:499-507. PubMed PMID: 31033351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain). AU - Andrés,Cristina, AU - Guasch,Eulàlia, AU - Piñana,Maria, AU - Fernandes,Paula, AU - Gimferrer,Laura, AU - Esso,Diego Van, AU - Codina,Maria Gema, AU - Esperalba,Juliana, AU - Vila,Jorgina, AU - Rodrigo,Carlos, AU - Martín,Maria Carmen, AU - Fuentes,Francisco, AU - Rubio,Susana, AU - Pumarola,Tomàs, AU - ,, AU - Antón,Andrés, Y1 - 2019/04/29/ PY - 2019/4/30/pubmed PY - 2019/8/7/medline PY - 2019/4/30/entrez KW - coxsackievirus A6 KW - enteroviruses KW - hand, food and mouth disease KW - herpangina KW - pediatric infections SP - 499 EP - 507 JF - Future microbiology JO - Future Microbiol VL - 14 N2 - Aim: To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017-2018 season. Methods: Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events. Results: An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol. Conclusion: The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers. SN - 1746-0921 UR - https://www.unboundmedicine.com/medline/citation/31033351/Recombinant_CV_A6_strains_related_to_hand_foot_mouth_disease_and_herpangina_at_primary_care_centers__Barcelona_Spain__ L2 - http://www.futuremedicine.com/doi/full/10.2217/fmb-2018-0336?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -