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[Clinical use of Gonadorelin as a diagnostic agent in one- and two-step tests].
Zentralbl Gynakol. 1986; 108(23):1442-52.ZG

Abstract

Synthetic LH/RH Gonadorelin, produced by VEB Berlin-Chemie, was given to 11 women with a normal menstrual cycle during the middle of the follicle phase. It was proved as a very effective drug, which provoked a typical gonadotropin release. Also 10 patients with a secondary amenorrhea responded already to the first intravenous injection of 80 micrograms Gonadorelin with a peak level of gonadotropins, in particular with LH levels, after 30 to 60 minutes (delta 1 = 1 st peak level--0' level). The relative ascent of gonadotropins (delta 2 = 2nd peak level--120' level) after the second step i.v. administration of 80 micrograms Gonadorelin at a 120 minutes interval was not significantly higher than delta 1. The reaction of pituitary on LH/RH does not immediately depend on the basal level of gonadotropin values. It reflects the severity of the hypothalamic-pituitary functional disturbance. The "Gonadorelin-test" ist a good complement to the progesterone- and clomiphene-test.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

3103350

Citation

Vesper, B, et al. "[Clinical Use of Gonadorelin as a Diagnostic Agent in One- and Two-step Tests]." Zentralblatt Fur Gynakologie, vol. 108, no. 23, 1986, pp. 1442-52.
Vesper B, Rohde W, Groot-Wassink T. [Clinical use of Gonadorelin as a diagnostic agent in one- and two-step tests]. Zentralbl Gynakol. 1986;108(23):1442-52.
Vesper, B., Rohde, W., & Groot-Wassink, T. (1986). [Clinical use of Gonadorelin as a diagnostic agent in one- and two-step tests]. Zentralblatt Fur Gynakologie, 108(23), 1442-52.
Vesper B, Rohde W, Groot-Wassink T. [Clinical Use of Gonadorelin as a Diagnostic Agent in One- and Two-step Tests]. Zentralbl Gynakol. 1986;108(23):1442-52. PubMed PMID: 3103350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical use of Gonadorelin as a diagnostic agent in one- and two-step tests]. AU - Vesper,B, AU - Rohde,W, AU - Groot-Wassink,T, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 1442 EP - 52 JF - Zentralblatt fur Gynakologie JO - Zentralbl Gynakol VL - 108 IS - 23 N2 - Synthetic LH/RH Gonadorelin, produced by VEB Berlin-Chemie, was given to 11 women with a normal menstrual cycle during the middle of the follicle phase. It was proved as a very effective drug, which provoked a typical gonadotropin release. Also 10 patients with a secondary amenorrhea responded already to the first intravenous injection of 80 micrograms Gonadorelin with a peak level of gonadotropins, in particular with LH levels, after 30 to 60 minutes (delta 1 = 1 st peak level--0' level). The relative ascent of gonadotropins (delta 2 = 2nd peak level--120' level) after the second step i.v. administration of 80 micrograms Gonadorelin at a 120 minutes interval was not significantly higher than delta 1. The reaction of pituitary on LH/RH does not immediately depend on the basal level of gonadotropin values. It reflects the severity of the hypothalamic-pituitary functional disturbance. The "Gonadorelin-test" ist a good complement to the progesterone- and clomiphene-test. SN - 0044-4197 UR - https://www.unboundmedicine.com/medline/citation/3103350/[Clinical_use_of_Gonadorelin_as_a_diagnostic_agent_in_one__and_two_step_tests]_ DB - PRIME DP - Unbound Medicine ER -