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Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics.
Cureus. 2019 Feb 22; 11(2):e4121.C

Abstract

Anemia is a common finding in alcoholics. It is often multifactorial and caused by a combination of liver dysfunction, ineffective erythropoiesis, and poor nutrition. Zieve's syndrome (ZS) is a clinical syndrome that presents with a triad of jaundice, hemolytic anemia, and hyperlipidemia secondary to alcohol use. Herein, we present a case of a 58-year-old male with a history of liver cirrhosis who presented after a fall due to binge drinking and was found to have severe anemia. Workup was consistent with hemolytic anemia with no source of active bleeding. The patient was managed with supportive treatment and blood transfusions which improved his anemia. However, given his advanced liver disease, he developed encephalopathy and subsequently severe aspiration pneumonia. He died 18 days after admission.

Authors+Show Affiliations

Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.Hematology and Oncology, University of Missouri-Kansas City School of Medicine, Kansas City, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31037235

Citation

Abughanimeh, Omar, et al. "Zieve's Syndrome: an Under-reported Cause of Anemia in Alcoholics." Cureus, vol. 11, no. 2, 2019, pp. e4121.
Abughanimeh O, Kaur A, Numan L, et al. Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics. Cureus. 2019;11(2):e4121.
Abughanimeh, O., Kaur, A., Numan, L., Bahaj, W., & Madhusudhana, S. (2019). Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics. Cureus, 11(2), e4121. https://doi.org/10.7759/cureus.4121
Abughanimeh O, et al. Zieve's Syndrome: an Under-reported Cause of Anemia in Alcoholics. Cureus. 2019 Feb 22;11(2):e4121. PubMed PMID: 31037235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics. AU - Abughanimeh,Omar, AU - Kaur,Anahat, AU - Numan,Laith, AU - Bahaj,Waled, AU - Madhusudhana,Sheshadri, Y1 - 2019/02/22/ PY - 2019/5/1/entrez PY - 2019/5/1/pubmed PY - 2019/5/1/medline KW - alcohol KW - anemia KW - hemolysis KW - hepatitis KW - jaundice KW - zieve's syndrome SP - e4121 EP - e4121 JF - Cureus JO - Cureus VL - 11 IS - 2 N2 - Anemia is a common finding in alcoholics. It is often multifactorial and caused by a combination of liver dysfunction, ineffective erythropoiesis, and poor nutrition. Zieve's syndrome (ZS) is a clinical syndrome that presents with a triad of jaundice, hemolytic anemia, and hyperlipidemia secondary to alcohol use. Herein, we present a case of a 58-year-old male with a history of liver cirrhosis who presented after a fall due to binge drinking and was found to have severe anemia. Workup was consistent with hemolytic anemia with no source of active bleeding. The patient was managed with supportive treatment and blood transfusions which improved his anemia. However, given his advanced liver disease, he developed encephalopathy and subsequently severe aspiration pneumonia. He died 18 days after admission. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/31037235/Zieve's_Syndrome:_An_Under-reported_Cause_of_Anemia_in_Alcoholics. L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31037235/ DB - PRIME DP - Unbound Medicine ER -
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