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Role of Periostin in Cardiac Valve Development.
Adv Exp Med Biol. 2019; 1132:177-191.AE

Abstract

Although periostin plays a significant role in adult cardiac remodeling diseases, the focus of this review is on periostin as a valvulogenic gene. Periostin is expressed throughout valvular development, initially being expressed in endocardial endothelial cells that have been activated to transform into prevalvular mesenchyme termed "cushion tissues" that sustain expression of periostin throughout their morphogenesis into mature (compacted) valve leaflets. The phenotype of periostin null indicates that periostin is not required for endocardial transformation nor the proliferation of its mesenchymal progeny but rather promotes cellular behaviors that promote migration, survival (anti-apoptotic), differentiation into fibroblastic lineages, collagen secretion and postnatal remodeling/maturation. These morphogenetic activities are promoted or coordinated by periostin signaling through integrin receptors activating downstream kinases in cushion cells that activate hyaluronan synthetase II (Akt/PI3K), collagen synthesis (Erk/MapK) and changes in cytoskeletal organization (Pak1) which regulate postnatal remodeling of cells and associated collagenous matrix into a trilaminar (zonal) histoarchitecture. Pak1 binding to filamin A is proposed as one mechanism by which periostin supports remodeling. The failure to properly remodel cushions sets up a trajectory of degenerative (myxomatous-like) changes that over time reduce biomechanical properties and increase chances for prolapse, regurgitation or calcification of the leaflets. Included in the review are considerations of lineage diversity and the role of periostin as a determinant of mesenchymal cell fate.

Authors+Show Affiliations

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina CRI 609, Charleston, SC, USA. markwald@musc.edu.Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina CRI 609, Charleston, SC, USA.Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina CRI 609, Charleston, SC, USA.Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina CRI 609, Charleston, SC, USA.Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina CRI 609, Charleston, SC, USA.Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina CRI 609, Charleston, SC, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31037635

Citation

Markwald, Roger R., et al. "Role of Periostin in Cardiac Valve Development." Advances in Experimental Medicine and Biology, vol. 1132, 2019, pp. 177-191.
Markwald RR, Moreno-Rodriguez RA, Ghatak S, et al. Role of Periostin in Cardiac Valve Development. Adv Exp Med Biol. 2019;1132:177-191.
Markwald, R. R., Moreno-Rodriguez, R. A., Ghatak, S., Misra, S., Norris, R. A., & Sugi, Y. (2019). Role of Periostin in Cardiac Valve Development. Advances in Experimental Medicine and Biology, 1132, 177-191. https://doi.org/10.1007/978-981-13-6657-4_17
Markwald RR, et al. Role of Periostin in Cardiac Valve Development. Adv Exp Med Biol. 2019;1132:177-191. PubMed PMID: 31037635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Periostin in Cardiac Valve Development. AU - Markwald,Roger R, AU - Moreno-Rodriguez,Ricardo A, AU - Ghatak,Sibnath, AU - Misra,Suniti, AU - Norris,Russell A, AU - Sugi,Yukiko, PY - 2019/5/1/entrez PY - 2019/5/1/pubmed PY - 2019/8/9/medline KW - Cell signaling KW - Cytoskeletal organization KW - Differentiation KW - Extraceular matrix KW - Fasciclins KW - Lineage KW - Periostin KW - Tissue remodeling KW - Valve disease SP - 177 EP - 191 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 1132 N2 - Although periostin plays a significant role in adult cardiac remodeling diseases, the focus of this review is on periostin as a valvulogenic gene. Periostin is expressed throughout valvular development, initially being expressed in endocardial endothelial cells that have been activated to transform into prevalvular mesenchyme termed "cushion tissues" that sustain expression of periostin throughout their morphogenesis into mature (compacted) valve leaflets. The phenotype of periostin null indicates that periostin is not required for endocardial transformation nor the proliferation of its mesenchymal progeny but rather promotes cellular behaviors that promote migration, survival (anti-apoptotic), differentiation into fibroblastic lineages, collagen secretion and postnatal remodeling/maturation. These morphogenetic activities are promoted or coordinated by periostin signaling through integrin receptors activating downstream kinases in cushion cells that activate hyaluronan synthetase II (Akt/PI3K), collagen synthesis (Erk/MapK) and changes in cytoskeletal organization (Pak1) which regulate postnatal remodeling of cells and associated collagenous matrix into a trilaminar (zonal) histoarchitecture. Pak1 binding to filamin A is proposed as one mechanism by which periostin supports remodeling. The failure to properly remodel cushions sets up a trajectory of degenerative (myxomatous-like) changes that over time reduce biomechanical properties and increase chances for prolapse, regurgitation or calcification of the leaflets. Included in the review are considerations of lineage diversity and the role of periostin as a determinant of mesenchymal cell fate. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/31037635/Role_of_Periostin_in_Cardiac_Valve_Development L2 - https://dx.doi.org/10.1007/978-981-13-6657-4_17 DB - PRIME DP - Unbound Medicine ER -