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Smoking status in relation to obstructive sleep apnea severity (OSA) and cardiovascular comorbidity in patients with newly diagnosed OSA.
Adv Respir Med. 2019; 87(2):103-109.AR

Abstract

INTRODUCTION

the relationship between smoking and sleep disturbance has been well documented. Smoking is a common risk factor for both obstructive sleep apnea (OSA) and cardiovascular diseases. The study aimed to: 1) evaluate the incidence of newly diagnosed OSA in patients presenting with symptoms suggestive of a sleep disorder, 2) assess the relation between smoking status and OSA severity; and 3) compare the prevalence of cardiovascular comorbidities in ever- and never smokers with newly diagnosed OSA.

MATERIAL AND METHODS

a retrospective analysis of 5,353 patients suspected of OSA was performed. OSA was diagnosed on the basis of polysomnography. The influence of smoking status on indices of OSA severity was evaluated and the incidence of self-reported cardiovascular diseases and diabetes mellitus type 2 was analyzed in relation to smoking history.

RESULTS

OSA was diagnosed in 3,613 patients (67.5%); of these, 21.6% were ever-smokers. Smokers with OSA had a higher apnea-hypopnea index [AHI; 31 (18.4-53.29) vs 29 (18.3-47.7), p = 0.03], lower mean oxygenation during sleep [92 (90-93) vs 92 (91-94), p < 0.01] and a higher daytime sleepiness (Epworth Sleepiness Scale score 11.7 ± 5.5 vs 11.0 ± 5.5, p < 0.001). The most frequent comorbidity was hypertension, followed by obesity, diabetes mellitus type 2 and coronary artery disease, with a statistically higher incidence of hypertension in non-smokers (59.2 vs 64.7 %, p = 0.005).

CONCLUSION

smoking is related with OSA severity and increased daytime sleepiness. Our study confirmed the elevated frequency of cardiovascular comorbidities in OSA patients in general but did not show an increased incidence of these comorbidities in smokers.

Authors+Show Affiliations

Medical University of Warsaw, Department of Internal Medicine, Pulmonary Diseases & Allergy, Stefana Banacha 1a, 02-097 Warsaw, Poland.Medical University of Warsaw, Department of Internal Medicine, Pulmonary Diseases & Allergy, Stefana Banacha 1a, 02-097 Warsaw, Poland. at.trojnar@gmail.com.Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.Medical University of Warsaw, Department of Internal Medicine, Pulmonary Diseases & Allergy, Stefana Banacha 1a, 02-097 Warsaw, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31038721

Citation

Bielicki, Piotr, et al. "Smoking Status in Relation to Obstructive Sleep Apnea Severity (OSA) and Cardiovascular Comorbidity in Patients With Newly Diagnosed OSA." Advances in Respiratory Medicine, vol. 87, no. 2, 2019, pp. 103-109.
Bielicki P, Trojnar A, Sobieraj P, et al. Smoking status in relation to obstructive sleep apnea severity (OSA) and cardiovascular comorbidity in patients with newly diagnosed OSA. Adv Respir Med. 2019;87(2):103-109.
Bielicki, P., Trojnar, A., Sobieraj, P., & Wąsik, M. (2019). Smoking status in relation to obstructive sleep apnea severity (OSA) and cardiovascular comorbidity in patients with newly diagnosed OSA. Advances in Respiratory Medicine, 87(2), 103-109. https://doi.org/10.5603/ARM.a2019.0011
Bielicki P, et al. Smoking Status in Relation to Obstructive Sleep Apnea Severity (OSA) and Cardiovascular Comorbidity in Patients With Newly Diagnosed OSA. Adv Respir Med. 2019;87(2):103-109. PubMed PMID: 31038721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking status in relation to obstructive sleep apnea severity (OSA) and cardiovascular comorbidity in patients with newly diagnosed OSA. AU - Bielicki,Piotr, AU - Trojnar,Anna, AU - Sobieraj,Piotr, AU - Wąsik,Magdalena, PY - 2019/01/31/received PY - 2019/03/25/accepted PY - 2019/03/14/revised PY - 2019/5/1/entrez PY - 2019/5/1/pubmed PY - 2019/12/25/medline KW - cardiovascular comorbidity KW - obstructive sleep apnea KW - smoking SP - 103 EP - 109 JF - Advances in respiratory medicine JO - Adv Respir Med VL - 87 IS - 2 N2 - INTRODUCTION: the relationship between smoking and sleep disturbance has been well documented. Smoking is a common risk factor for both obstructive sleep apnea (OSA) and cardiovascular diseases. The study aimed to: 1) evaluate the incidence of newly diagnosed OSA in patients presenting with symptoms suggestive of a sleep disorder, 2) assess the relation between smoking status and OSA severity; and 3) compare the prevalence of cardiovascular comorbidities in ever- and never smokers with newly diagnosed OSA. MATERIAL AND METHODS: a retrospective analysis of 5,353 patients suspected of OSA was performed. OSA was diagnosed on the basis of polysomnography. The influence of smoking status on indices of OSA severity was evaluated and the incidence of self-reported cardiovascular diseases and diabetes mellitus type 2 was analyzed in relation to smoking history. RESULTS: OSA was diagnosed in 3,613 patients (67.5%); of these, 21.6% were ever-smokers. Smokers with OSA had a higher apnea-hypopnea index [AHI; 31 (18.4-53.29) vs 29 (18.3-47.7), p = 0.03], lower mean oxygenation during sleep [92 (90-93) vs 92 (91-94), p < 0.01] and a higher daytime sleepiness (Epworth Sleepiness Scale score 11.7 ± 5.5 vs 11.0 ± 5.5, p < 0.001). The most frequent comorbidity was hypertension, followed by obesity, diabetes mellitus type 2 and coronary artery disease, with a statistically higher incidence of hypertension in non-smokers (59.2 vs 64.7 %, p = 0.005). CONCLUSION: smoking is related with OSA severity and increased daytime sleepiness. Our study confirmed the elevated frequency of cardiovascular comorbidities in OSA patients in general but did not show an increased incidence of these comorbidities in smokers. SN - 2543-6031 UR - https://www.unboundmedicine.com/medline/citation/31038721/Smoking_status_in_relation_to_obstructive_sleep_apnea_severity__OSA__and_cardiovascular_comorbidity_in_patients_with_newly_diagnosed_OSA_ L2 - https://journals.viamedica.pl/advances_in_respiratory_medicine/article/view/62932 DB - PRIME DP - Unbound Medicine ER -