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The role of vehicle metamorphosis on triamcinolone acetonide delivery to the skin from microemulsions.
Int J Pharm. 2019 Jun 30; 565:33-40.IJ

Abstract

After application to the skin surface, a topical formulation is submitted to changes in composition produced by evaporation of volatile components, penetration of components into the skin and extraction of skin components ("vehicle metamorphosis"). The aim of this work was to study the effect of vehicle metamorphosis on skin delivery from microemulsions containing triamcinolone acetonide. The microemulsions were prepared and characterized for water evaporation kinetics, in vitro release and skin permeation and retention. Skin retention experiments were performed on full thickness pig ear skin, in both occluded infinite and un-occluded finite dose conditions. For comparison purposes, two creams, the commercial Ledercort® and a vanishing cream, were tested. With triamcinolone acetonide water evaporation does not modify skin retention, probably for the lipophilic nature of the drug. However, if water is eliminated from the microemulsions, the performance is reduced, probably because drug partitioning from vehicle to stratum corneum is disfavored. If a water-soluble drug (methyl prednisolone sodium succinate) is used, infinite dose application in occlusive conditions increases in a significant way the amount of drug retained in the skin. The involved mechanisms are probably stratum corneum swelling and increase of stratum corneum/viable epidermis partitioning.

Authors+Show Affiliations

Department of Food and Drug, Parco Area delle Scienze 27/A, University of Parma, 43124 Parma, Italy.Department of Food and Drug, Parco Area delle Scienze 27/A, University of Parma, 43124 Parma, Italy.Department of Food and Drug, Parco Area delle Scienze 27/A, University of Parma, 43124 Parma, Italy.Department of Food and Drug, Parco Area delle Scienze 27/A, University of Parma, 43124 Parma, Italy.Department of Food and Drug, Parco Area delle Scienze 27/A, University of Parma, 43124 Parma, Italy. Electronic address: patrizia.santi@unipr.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31039388

Citation

Fantini, Adriana, et al. "The Role of Vehicle Metamorphosis On Triamcinolone Acetonide Delivery to the Skin From Microemulsions." International Journal of Pharmaceutics, vol. 565, 2019, pp. 33-40.
Fantini A, Padula C, Nicoli S, et al. The role of vehicle metamorphosis on triamcinolone acetonide delivery to the skin from microemulsions. Int J Pharm. 2019;565:33-40.
Fantini, A., Padula, C., Nicoli, S., Pescina, S., & Santi, P. (2019). The role of vehicle metamorphosis on triamcinolone acetonide delivery to the skin from microemulsions. International Journal of Pharmaceutics, 565, 33-40. https://doi.org/10.1016/j.ijpharm.2019.04.072
Fantini A, et al. The Role of Vehicle Metamorphosis On Triamcinolone Acetonide Delivery to the Skin From Microemulsions. Int J Pharm. 2019 Jun 30;565:33-40. PubMed PMID: 31039388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of vehicle metamorphosis on triamcinolone acetonide delivery to the skin from microemulsions. AU - Fantini,Adriana, AU - Padula,Cristina, AU - Nicoli,Sara, AU - Pescina,Silvia, AU - Santi,Patrizia, Y1 - 2019/04/27/ PY - 2019/01/23/received PY - 2019/04/05/revised PY - 2019/04/26/accepted PY - 2019/5/1/pubmed PY - 2019/12/4/medline PY - 2019/5/1/entrez KW - Methyl prednisolone sodium succinate KW - Microemulsions KW - Skin retention KW - Triamcinolone acetonide KW - Vehicle metamorphosis SP - 33 EP - 40 JF - International journal of pharmaceutics JO - Int J Pharm VL - 565 N2 - After application to the skin surface, a topical formulation is submitted to changes in composition produced by evaporation of volatile components, penetration of components into the skin and extraction of skin components ("vehicle metamorphosis"). The aim of this work was to study the effect of vehicle metamorphosis on skin delivery from microemulsions containing triamcinolone acetonide. The microemulsions were prepared and characterized for water evaporation kinetics, in vitro release and skin permeation and retention. Skin retention experiments were performed on full thickness pig ear skin, in both occluded infinite and un-occluded finite dose conditions. For comparison purposes, two creams, the commercial Ledercort® and a vanishing cream, were tested. With triamcinolone acetonide water evaporation does not modify skin retention, probably for the lipophilic nature of the drug. However, if water is eliminated from the microemulsions, the performance is reduced, probably because drug partitioning from vehicle to stratum corneum is disfavored. If a water-soluble drug (methyl prednisolone sodium succinate) is used, infinite dose application in occlusive conditions increases in a significant way the amount of drug retained in the skin. The involved mechanisms are probably stratum corneum swelling and increase of stratum corneum/viable epidermis partitioning. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/31039388/The_role_of_vehicle_metamorphosis_on_triamcinolone_acetonide_delivery_to_the_skin_from_microemulsions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(19)30343-6 DB - PRIME DP - Unbound Medicine ER -