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Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results from the NIH-AARP Diet and Health Study.
Cancer Epidemiol Biomarkers Prev 2019; 28(7):1266-1270CE

Abstract

BACKGROUND

Chronic inflammation is implicated in pancreatic cancer, and can be modulated by diet and other lifestyle factors. We examined the association between Dietary Inflammatory Index (DII) scores and pancreatic cancer risk in the NIH-AARP Diet and Health Study, and examined effect modification by inflammation-related lifestyle factors, including body mass index, cigarette smoking, diabetes, alcohol drinking, and use of non-steroidal anti-inflammatory drugs.

METHODS

Energy-adjusted DII scores (E-DII) were computed on the basis of food frequency questionnaire responses for foods and dietary supplements. Cox proportional hazards models were fitted and effect modification was examined by adding a cross-product of each effect modifier with E-DII quintile in the multivariable-adjusted model.

RESULTS

There were 2,824 primary incident pancreatic cancers diagnosed during a median of 13.4 years follow-up, and there was no association between E-DII scores and pancreatic cancer risk among either men [HRQ5vsQ1, 1.00; 95% confidence interval (CI), 0.86-1.16] or women (HRQ5vsQ1, 1.00; 95% CI, 0.82-1.21) in the multivariable-adjusted model, and no association was detected by any cancer stage. The E-DII and pancreatic cancer association was not modified by any of the inflammation-related lifestyle factors examined.

CONCLUSIONS

Results from this large prospective study did not support an association between inflammatory potential of diet and pancreatic cancer, or effect modification by other inflammation-related lifestyle factors.

IMPACT

Inflammatory potential of diet may not be related to pancreatic cancer risk. Future cohort studies with more frequent dietary measures could be useful in determining the appropriate timing of dietary intake in relation to pancreatic cancer etiology.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. Department of Epidemiology, Division of Cancer Prevention and Population Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina. Connecting Health Innovations, LLC, Columbia, South Carolina.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina. Connecting Health Innovations, LLC, Columbia, South Carolina.Division of Cancer Epidemiology and Genetics, Metabolic Epidemiology Branch, National Cancer Institute (NCI/DCEG), Bethesda, Maryland.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina. Connecting Health Innovations, LLC, Columbia, South Carolina.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. ssteck@sc.edu. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31040136

Citation

Zheng, Jiali, et al. "Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results From the NIH-AARP Diet and Health Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 28, no. 7, 2019, pp. 1266-1270.
Zheng J, Wirth MD, Merchant AT, et al. Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results from the NIH-AARP Diet and Health Study. Cancer Epidemiol Biomarkers Prev. 2019;28(7):1266-1270.
Zheng, J., Wirth, M. D., Merchant, A. T., Zhang, J., Shivappa, N., Stolzenberg-Solomon, R. Z., ... Steck, S. E. (2019). Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results from the NIH-AARP Diet and Health Study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 28(7), pp. 1266-1270. doi:10.1158/1055-9965.EPI-19-0250.
Zheng J, et al. Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results From the NIH-AARP Diet and Health Study. Cancer Epidemiol Biomarkers Prev. 2019;28(7):1266-1270. PubMed PMID: 31040136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results from the NIH-AARP Diet and Health Study. AU - Zheng,Jiali, AU - Wirth,Michael D, AU - Merchant,Anwar T, AU - Zhang,Jiajia, AU - Shivappa,Nitin, AU - Stolzenberg-Solomon,Rachael Z, AU - Hebert,James R, AU - Steck,Susan E, Y1 - 2019/04/30/ PY - 2019/03/08/received PY - 2019/04/26/revised PY - 2019/04/26/accepted PY - 2020/07/01/pmc-release PY - 2019/5/2/pubmed PY - 2019/5/2/medline PY - 2019/5/2/entrez SP - 1266 EP - 1270 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 28 IS - 7 N2 - BACKGROUND: Chronic inflammation is implicated in pancreatic cancer, and can be modulated by diet and other lifestyle factors. We examined the association between Dietary Inflammatory Index (DII) scores and pancreatic cancer risk in the NIH-AARP Diet and Health Study, and examined effect modification by inflammation-related lifestyle factors, including body mass index, cigarette smoking, diabetes, alcohol drinking, and use of non-steroidal anti-inflammatory drugs. METHODS: Energy-adjusted DII scores (E-DII) were computed on the basis of food frequency questionnaire responses for foods and dietary supplements. Cox proportional hazards models were fitted and effect modification was examined by adding a cross-product of each effect modifier with E-DII quintile in the multivariable-adjusted model. RESULTS: There were 2,824 primary incident pancreatic cancers diagnosed during a median of 13.4 years follow-up, and there was no association between E-DII scores and pancreatic cancer risk among either men [HRQ5vsQ1, 1.00; 95% confidence interval (CI), 0.86-1.16] or women (HRQ5vsQ1, 1.00; 95% CI, 0.82-1.21) in the multivariable-adjusted model, and no association was detected by any cancer stage. The E-DII and pancreatic cancer association was not modified by any of the inflammation-related lifestyle factors examined. CONCLUSIONS: Results from this large prospective study did not support an association between inflammatory potential of diet and pancreatic cancer, or effect modification by other inflammation-related lifestyle factors. IMPACT: Inflammatory potential of diet may not be related to pancreatic cancer risk. Future cohort studies with more frequent dietary measures could be useful in determining the appropriate timing of dietary intake in relation to pancreatic cancer etiology. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/31040136/Inflammatory_Potential_of_Diet_Inflammation_Related_Lifestyle_Factors_and_Risk_of_Pancreatic_Cancer:_Results_from_the_NIH_AARP_Diet_and_Health_Study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=31040136 DB - PRIME DP - Unbound Medicine ER -