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Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome.
Acta Derm Venereol 2019; 99(9):809-812AD

Abstract

Tumor cells in cutaneous T-cell lymphoma express limited numbers of chemokine receptors. We investigated the expression patterns of CXCR3, CCR3, CCR4 and CCR10 in mycosis fungoides, Sézary syndrome, lym-phomatoid papulosis and anaplastic large cell lymphoma in 121 skin biopsy samples. CXCR3 was expressed in 86% of mycosis fungoides cases but in no anaplastic large cell lymphoma cases. CCR3 was expressed in 73% of cases of CD30+ lymphoproliferative disorders such as lymphomatoid papulosis and anaplastic large cell lymphoma. Mycosis fungoides/Sézary syndrome patients with high CCR3 or CCR4 expression had a poorer survival prognosis than mycosis fungoides/Sézary syndrome patients whose tumor cells did not express these receptors. CCR10 was expressed in 50% of mycosis fungoides/Sézary syndrome cases and in 13% of cases with CD30+ lym-phoproliferative disorders. These results suggest that differential patterns of CXCR3, CCR3, CCR4 and CCR10 expression are useful for the diagnosis of cutaneous T-cell lymphoma. Moreover, expression of CCR3 or CCR4 suggests a poor prognosis in mycosis fungoides/Sézary syndrome.

Authors+Show Affiliations

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31045236

Citation

Shono, Yuki, et al. "Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome." Acta Dermato-venereologica, vol. 99, no. 9, 2019, pp. 809-812.
Shono Y, Suga H, Kamijo H, et al. Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome. Acta Derm Venereol. 2019;99(9):809-812.
Shono, Y., Suga, H., Kamijo, H., Fujii, H., Oka, T., Miyagaki, T., ... Sato, S. (2019). Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome. Acta Dermato-venereologica, 99(9), pp. 809-812. doi:10.2340/00015555-3207.
Shono Y, et al. Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome. Acta Derm Venereol. 2019 Jul 1;99(9):809-812. PubMed PMID: 31045236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome. AU - Shono,Yuki, AU - Suga,Hiraku, AU - Kamijo,Hiroaki, AU - Fujii,Hikari, AU - Oka,Tomonori, AU - Miyagaki,Tomomitsu, AU - Shishido-Takahashi,Naomi, AU - Sugaya,Makoto, AU - Sato,Shinichi, PY - 2019/5/3/pubmed PY - 2019/5/3/medline PY - 2019/5/3/entrez KW - CCR10 KW - CCR3 KW - CCR4 KW - CXCR3 KW - CTCL SP - 809 EP - 812 JF - Acta dermato-venereologica JO - Acta Derm. Venereol. VL - 99 IS - 9 N2 - Tumor cells in cutaneous T-cell lymphoma express limited numbers of chemokine receptors. We investigated the expression patterns of CXCR3, CCR3, CCR4 and CCR10 in mycosis fungoides, Sézary syndrome, lym-phomatoid papulosis and anaplastic large cell lymphoma in 121 skin biopsy samples. CXCR3 was expressed in 86% of mycosis fungoides cases but in no anaplastic large cell lymphoma cases. CCR3 was expressed in 73% of cases of CD30+ lymphoproliferative disorders such as lymphomatoid papulosis and anaplastic large cell lymphoma. Mycosis fungoides/Sézary syndrome patients with high CCR3 or CCR4 expression had a poorer survival prognosis than mycosis fungoides/Sézary syndrome patients whose tumor cells did not express these receptors. CCR10 was expressed in 50% of mycosis fungoides/Sézary syndrome cases and in 13% of cases with CD30+ lym-phoproliferative disorders. These results suggest that differential patterns of CXCR3, CCR3, CCR4 and CCR10 expression are useful for the diagnosis of cutaneous T-cell lymphoma. Moreover, expression of CCR3 or CCR4 suggests a poor prognosis in mycosis fungoides/Sézary syndrome. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/31045236/Expression_of_CCR3_and_CCR4_Suggests_a_Poor_Prognosis_in_Mycosis_Fungoides_and_Sézary_Syndrome_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3207 DB - PRIME DP - Unbound Medicine ER -