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Correlation Analysis between Foveal Avascular Zone and Peripheral Ischemic Index in Diabetic Retinopathy: A Pilot Study.
Ophthalmol Retina. 2018 01; 2(1):46-52.OR

Abstract

PURPOSE

To investigate the foveal avascular zone (FAZ) by OCT angiography (OCT-A) in patients affected by diabetic retinopathy and its correlation with peripheral retinal ischemic index.

DESIGN

Observational, cross-sectional study, prospectively designed.

PARTICIPANTS

Consecutive patients with treatment-naïve diabetic retinopathy were prospectively recruited between October 2015 and January 2017.

METHODS

All patients underwent a comprehensive ocular examination including OCT, OCT-A, ultra-widefield (UWF) color fundus images, and UWF fluorescein angiography.

MAIN OUTCOME MEASURES

Variables analyzed included best-corrected visual acuity (BCVA) expressed in logarithm of the minimal angle of resolution (logMAR); diabetic retinopathy grading; FAZ area at full-thickness (internal limiting membrane to Bruch's membrane) OCT-A angiogram; superficial capillary plexus; deep capillary plexus; ischemic index; and central macular thickness (CMT).

RESULTS

Twenty-two eyes of 22 patients (11 male, mean age 54.9±15.8 years) were included. Mean FAZ areas at full thickness, superficial plexus, and deep plexus were 0.331±0.137 mm2, 0.340±0.140 mm2, and 1.028±0.447 mm2, respectively. Mean ischemic index was 13.6% (range, 0%-50.2%). A significant correlation was found between ischemic index and FAZ area at both full-thickness (r = 0.60, P = 0.0035) and superficial (r = 0.68, P = 0.0005) layers. Disease severity correlated to ischemic index (r = 0.49, P = 0.0204), and FAZ area at full-thickness (r = 0.53, P = 0.0108) and superficial (r = 0.47, P = 0.0292) plexuses. No significant correlation between ischemic index and FAZ at deep plexus was found. BCVA correlated only to CMT (r = 0.66, P = 0.0008).

CONCLUSIONS

The association between peripheral and macular perfusion found in this study supports the hypothesis that both conditions share a common pathogenic mechanism that leads to capillary nonperfusion.

Authors+Show Affiliations

Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy. Electronic address: giuseppe.querques@hotmail.it.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

31047302

Citation

Rabiolo, Alessandro, et al. "Correlation Analysis Between Foveal Avascular Zone and Peripheral Ischemic Index in Diabetic Retinopathy: a Pilot Study." Ophthalmology. Retina, vol. 2, no. 1, 2018, pp. 46-52.
Rabiolo A, Cicinelli MV, Corbelli E, et al. Correlation Analysis between Foveal Avascular Zone and Peripheral Ischemic Index in Diabetic Retinopathy: A Pilot Study. Ophthalmol Retina. 2018;2(1):46-52.
Rabiolo, A., Cicinelli, M. V., Corbelli, E., Baldin, G., Carnevali, A., Lattanzio, R., Querques, L., Bandello, F., & Querques, G. (2018). Correlation Analysis between Foveal Avascular Zone and Peripheral Ischemic Index in Diabetic Retinopathy: A Pilot Study. Ophthalmology. Retina, 2(1), 46-52. https://doi.org/10.1016/j.oret.2017.05.007
Rabiolo A, et al. Correlation Analysis Between Foveal Avascular Zone and Peripheral Ischemic Index in Diabetic Retinopathy: a Pilot Study. Ophthalmol Retina. 2018;2(1):46-52. PubMed PMID: 31047302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation Analysis between Foveal Avascular Zone and Peripheral Ischemic Index in Diabetic Retinopathy: A Pilot Study. AU - Rabiolo,Alessandro, AU - Cicinelli,Maria Vittoria, AU - Corbelli,Eleonora, AU - Baldin,Giovanni, AU - Carnevali,Adriano, AU - Lattanzio,Rosangela, AU - Querques,Lea, AU - Bandello,Francesco, AU - Querques,Giuseppe, Y1 - 2017/07/26/ PY - 2016/10/05/received PY - 2017/05/10/revised PY - 2017/05/17/accepted PY - 2019/5/4/entrez PY - 2018/1/1/pubmed PY - 2019/7/26/medline SP - 46 EP - 52 JF - Ophthalmology. Retina JO - Ophthalmol Retina VL - 2 IS - 1 N2 - PURPOSE: To investigate the foveal avascular zone (FAZ) by OCT angiography (OCT-A) in patients affected by diabetic retinopathy and its correlation with peripheral retinal ischemic index. DESIGN: Observational, cross-sectional study, prospectively designed. PARTICIPANTS: Consecutive patients with treatment-naïve diabetic retinopathy were prospectively recruited between October 2015 and January 2017. METHODS: All patients underwent a comprehensive ocular examination including OCT, OCT-A, ultra-widefield (UWF) color fundus images, and UWF fluorescein angiography. MAIN OUTCOME MEASURES: Variables analyzed included best-corrected visual acuity (BCVA) expressed in logarithm of the minimal angle of resolution (logMAR); diabetic retinopathy grading; FAZ area at full-thickness (internal limiting membrane to Bruch's membrane) OCT-A angiogram; superficial capillary plexus; deep capillary plexus; ischemic index; and central macular thickness (CMT). RESULTS: Twenty-two eyes of 22 patients (11 male, mean age 54.9±15.8 years) were included. Mean FAZ areas at full thickness, superficial plexus, and deep plexus were 0.331±0.137 mm2, 0.340±0.140 mm2, and 1.028±0.447 mm2, respectively. Mean ischemic index was 13.6% (range, 0%-50.2%). A significant correlation was found between ischemic index and FAZ area at both full-thickness (r = 0.60, P = 0.0035) and superficial (r = 0.68, P = 0.0005) layers. Disease severity correlated to ischemic index (r = 0.49, P = 0.0204), and FAZ area at full-thickness (r = 0.53, P = 0.0108) and superficial (r = 0.47, P = 0.0292) plexuses. No significant correlation between ischemic index and FAZ at deep plexus was found. BCVA correlated only to CMT (r = 0.66, P = 0.0008). CONCLUSIONS: The association between peripheral and macular perfusion found in this study supports the hypothesis that both conditions share a common pathogenic mechanism that leads to capillary nonperfusion. SN - 2468-6530 UR - https://www.unboundmedicine.com/medline/citation/31047302/Correlation_Analysis_between_Foveal_Avascular_Zone_and_Peripheral_Ischemic_Index_in_Diabetic_Retinopathy:_A_Pilot_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2468-6530(16)30079-3 DB - PRIME DP - Unbound Medicine ER -