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Effect of Shuangjinlian mixture on oral ulcer model in rat.
Saudi J Biol Sci 2019; 26(4):790-794SJ

Abstract

Objective

To observe the effect of common clinical drug Shuangjin Lian mixture on rats with oral ulcer and discuss its mechanism.

Methods

Sodium carboxymethyl cellulose caused leukocyte aggregation in rats, observed the anti-inflammatory effect of Shuangjin mixture. 3 mm * 3 mm size ulcer surface in the oral cavity of rats was caused by 90% phenol solution, to observe the therapeutic effect and anti-inflammatory effect of Shuangjinlian mixture on rats with oral ulcers.

Result

The low, middle and high dose Shuangjinlian mixture can inhibits the accumulation of white blood cells caused by sodium carboxymethyl cellulose in rats significantly (P < 0.01). And reduce the degree of edema and hyperaemia around the ulcer tissue significantly (P < 0.01), improve the ulcer healing probability, and reduce the level of TNF-α, VEGF levels and increase IL-2 level in the serum of rats with oral ulcers significantly (P < 0.01). Pathological examination showed that the lesion of ulcer tissue in each treatment group was obviously alleviated.

Conclusion

Shuangjinlian mixture had anti-inflammatory effect and was effective for the prevention and treatment of oral ulcer in rats.

Authors+Show Affiliations

Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, Henan, China.Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, Henan, China.Henan Tai Long Pharmaceutical Limited by Share Ltd, Zhengzhou, Henan, China.Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, Henan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31049005

Citation

Miao, Mingsan, et al. "Effect of Shuangjinlian Mixture On Oral Ulcer Model in Rat." Saudi Journal of Biological Sciences, vol. 26, no. 4, 2019, pp. 790-794.
Miao M, Peng M, Xing Z, et al. Effect of Shuangjinlian mixture on oral ulcer model in rat. Saudi J Biol Sci. 2019;26(4):790-794.
Miao, M., Peng, M., Xing, Z., & Liu, D. (2019). Effect of Shuangjinlian mixture on oral ulcer model in rat. Saudi Journal of Biological Sciences, 26(4), pp. 790-794. doi:10.1016/j.sjbs.2019.02.005.
Miao M, et al. Effect of Shuangjinlian Mixture On Oral Ulcer Model in Rat. Saudi J Biol Sci. 2019;26(4):790-794. PubMed PMID: 31049005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Shuangjinlian mixture on oral ulcer model in rat. AU - Miao,Mingsan, AU - Peng,Mengfan, AU - Xing,Zetian, AU - Liu,Dandan, Y1 - 2019/02/16/ PY - 2018/08/10/received PY - 2019/02/12/revised PY - 2019/02/12/accepted PY - 2019/5/4/entrez PY - 2019/5/3/pubmed PY - 2019/5/3/medline KW - Anti-inflammatory KW - Oral ulcer KW - Proprietary Chinese medicine KW - Rat model KW - Shuangjinlian mixture SP - 790 EP - 794 JF - Saudi journal of biological sciences JO - Saudi J Biol Sci VL - 26 IS - 4 N2 - Objective: To observe the effect of common clinical drug Shuangjin Lian mixture on rats with oral ulcer and discuss its mechanism. Methods: Sodium carboxymethyl cellulose caused leukocyte aggregation in rats, observed the anti-inflammatory effect of Shuangjin mixture. 3 mm * 3 mm size ulcer surface in the oral cavity of rats was caused by 90% phenol solution, to observe the therapeutic effect and anti-inflammatory effect of Shuangjinlian mixture on rats with oral ulcers. Result: The low, middle and high dose Shuangjinlian mixture can inhibits the accumulation of white blood cells caused by sodium carboxymethyl cellulose in rats significantly (P < 0.01). And reduce the degree of edema and hyperaemia around the ulcer tissue significantly (P < 0.01), improve the ulcer healing probability, and reduce the level of TNF-α, VEGF levels and increase IL-2 level in the serum of rats with oral ulcers significantly (P < 0.01). Pathological examination showed that the lesion of ulcer tissue in each treatment group was obviously alleviated. Conclusion: Shuangjinlian mixture had anti-inflammatory effect and was effective for the prevention and treatment of oral ulcer in rats. SN - 1319-562X UR - https://www.unboundmedicine.com/medline/citation/31049005/Effect_of_Shuangjinlian_mixture_on_oral_ulcer_model_in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1319-562X(19)30020-8 DB - PRIME DP - Unbound Medicine ER -