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Effects of compound lobelia oral liquid on acute pharyngitis rabbits model.
Saudi J Biol Sci 2019; 26(4):816-820SJ

Abstract

Aims

Explore the effect of compound lobelia oral liquid on acute pharyngitis rabbits model caused by ammonium hydroxide, evaluate its curative effect.

Methods

Acute pharyngitis rabbit model was prepared by ammonia spray at pharyngeal. After 1 h of the last administration, score the pharyngeal tissue symptoms of rabbits under the condition of naked eyes (score according to the score criteria). Then, take blood from the marginal auricular vein for routine blood tests and serum TNF-α level measure. Take pharyngeal tissue for HE staining, and observe its pathological changes under the microscope.

Results

Compared with the blank group, the pharyngeal tissue symptom score and serum TNF-α level in the model group were significantly increased (P < 0.01). The results of blood routine showed that the number of white blood cells and lymphocytes in the model group increased significantly (P < 0.01), and neutrophilic granulocyte percentage decreased significantly (P < 0.01). The infiltration of inflammatory cells in the pharynx tissue was obvious and pathological changes were observed. Compared with the model group, large, middle and small doses of compound lobelia oral liquid group could reduce the scores of pharyngeal tissue symptoms in rabbits with acute pharyngitis induced by ammonia. The large and middle dose compound lobelia oral liquid group could significantly reduce serum TNF-α level and neutrophilic granulocyte percentage, significantly increase the number of white blood cells and lymphocytes (P < 0.01); The small dose compound lobelia oral liquid group could significantly reduce the number of white blood cells and lymphocytes (P < 0.01), there was an increasing tendency to neutrophils and a decreasing tendency to serum TNF-α, but no statistical significance. The large, middle and small doses of compound lobelia oral liquid group all could improve the pathological changes of pharyngeal tissue inflammatory infiltration.

Conclusion

Compound lobelia oral liquid has a good effect on rabbit acute pharyngitis model caused by ammonia.

Authors+Show Affiliations

College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31049008

Citation

Miao, Mingsan, et al. "Effects of Compound Lobelia Oral Liquid On Acute Pharyngitis Rabbits Model." Saudi Journal of Biological Sciences, vol. 26, no. 4, 2019, pp. 816-820.
Miao M, Peng M, Liu B, et al. Effects of compound lobelia oral liquid on acute pharyngitis rabbits model. Saudi J Biol Sci. 2019;26(4):816-820.
Miao, M., Peng, M., Liu, B., & Bai, M. (2019). Effects of compound lobelia oral liquid on acute pharyngitis rabbits model. Saudi Journal of Biological Sciences, 26(4), pp. 816-820. doi:10.1016/j.sjbs.2019.02.008.
Miao M, et al. Effects of Compound Lobelia Oral Liquid On Acute Pharyngitis Rabbits Model. Saudi J Biol Sci. 2019;26(4):816-820. PubMed PMID: 31049008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of compound lobelia oral liquid on acute pharyngitis rabbits model. AU - Miao,Mingsan, AU - Peng,Mengfan, AU - Liu,Baosong, AU - Bai,Ming, Y1 - 2019/02/20/ PY - 2018/08/13/received PY - 2019/02/19/revised PY - 2019/02/19/accepted PY - 2019/5/4/entrez PY - 2019/5/3/pubmed PY - 2019/5/3/medline KW - Acute pharyngitis KW - Blood routine examination KW - Pathological changes SP - 816 EP - 820 JF - Saudi journal of biological sciences JO - Saudi J Biol Sci VL - 26 IS - 4 N2 - Aims: Explore the effect of compound lobelia oral liquid on acute pharyngitis rabbits model caused by ammonium hydroxide, evaluate its curative effect. Methods: Acute pharyngitis rabbit model was prepared by ammonia spray at pharyngeal. After 1 h of the last administration, score the pharyngeal tissue symptoms of rabbits under the condition of naked eyes (score according to the score criteria). Then, take blood from the marginal auricular vein for routine blood tests and serum TNF-α level measure. Take pharyngeal tissue for HE staining, and observe its pathological changes under the microscope. Results: Compared with the blank group, the pharyngeal tissue symptom score and serum TNF-α level in the model group were significantly increased (P < 0.01). The results of blood routine showed that the number of white blood cells and lymphocytes in the model group increased significantly (P < 0.01), and neutrophilic granulocyte percentage decreased significantly (P < 0.01). The infiltration of inflammatory cells in the pharynx tissue was obvious and pathological changes were observed. Compared with the model group, large, middle and small doses of compound lobelia oral liquid group could reduce the scores of pharyngeal tissue symptoms in rabbits with acute pharyngitis induced by ammonia. The large and middle dose compound lobelia oral liquid group could significantly reduce serum TNF-α level and neutrophilic granulocyte percentage, significantly increase the number of white blood cells and lymphocytes (P < 0.01); The small dose compound lobelia oral liquid group could significantly reduce the number of white blood cells and lymphocytes (P < 0.01), there was an increasing tendency to neutrophils and a decreasing tendency to serum TNF-α, but no statistical significance. The large, middle and small doses of compound lobelia oral liquid group all could improve the pathological changes of pharyngeal tissue inflammatory infiltration. Conclusion: Compound lobelia oral liquid has a good effect on rabbit acute pharyngitis model caused by ammonia. SN - 1319-562X UR - https://www.unboundmedicine.com/medline/citation/31049008/Effects_of_compound_lobelia_oral_liquid_on_acute_pharyngitis_rabbits_model L2 - https://linkinghub.elsevier.com/retrieve/pii/S1319-562X(19)30022-1 DB - PRIME DP - Unbound Medicine ER -