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Vitamin E and Alzheimer's disease: the mediating role of cellular aging.
Aging Clin Exp Res. 2020 Mar; 32(3):459-464.AC

Abstract

BACKGROUND

Vitamin E represents a potent antioxidant and anti-inflammatory system, playing a role in Alzheimer's disease (AD). Different plasma concentrations of the forms of vitamin E are observed in AD compared to cognitively healthy subjects.

AIM

Since these modifications may modulate the markers of oxidative stress and cellular aging, we aim to explore the relationship between vitamin E forms and leukocyte telomere length (LTL) in AD.

METHODS

53 AD subjects and 40 cognitively healthy controls (CTs) were enrolled. The vitamin E forms (α-, β-, γ- and δ-tocopherol, α-, β-, γ- and δ-tocotrienol), the ratio of α-tocopherylquinone/α-tocopherol and 5-nitro-γ-tocopherol/γ-tocopherol (markers of oxidative/nitrosative damage) and LTL were measured.

RESULTS AND DISCUSSION

Regression model was used to explore the associations of vitamin E forms and LTL with AD. The interaction of LTL in the association between vitamin E forms and AD was tested. AD subjects showed significantly lower concentrations of α-, β-, γ- and δ-tocopherol, α- and δ-tocotrienol, total tocopherols, total tocotrienols and total vitamin E compared to CTs. AD subjects showed higher values of nitrosative/oxidative damage. The adjusted analyses confirmed a significant relationship of AD with plasma concentrations of α- and β-tocopherols, δ-tocotrienol, total tocopherols, total tocotrienol, total vitamin E and oxidative/nitrosative damage. However, nitrosative damage was significantly associated with AD only in subjects with higher LTL and not in those expressing marked cellular aging.

CONCLUSIONS

Our study confirms the role of vitamin E in AD pathology and indicates that nitrosative damage influences the association with AD only in subjects characterized by longer LTL.

Authors+Show Affiliations

Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy. martina.casati@unimi.it.Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy.Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy.Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy.Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy.Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy. Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122, Milan, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31054115

Citation

Casati, Martina, et al. "Vitamin E and Alzheimer's Disease: the Mediating Role of Cellular Aging." Aging Clinical and Experimental Research, vol. 32, no. 3, 2020, pp. 459-464.
Casati M, Boccardi V, Ferri E, et al. Vitamin E and Alzheimer's disease: the mediating role of cellular aging. Aging Clin Exp Res. 2020;32(3):459-464.
Casati, M., Boccardi, V., Ferri, E., Bertagnoli, L., Bastiani, P., Ciccone, S., Mansi, M., Scamosci, M., Rossi, P. D., Mecocci, P., & Arosio, B. (2020). Vitamin E and Alzheimer's disease: the mediating role of cellular aging. Aging Clinical and Experimental Research, 32(3), 459-464. https://doi.org/10.1007/s40520-019-01209-3
Casati M, et al. Vitamin E and Alzheimer's Disease: the Mediating Role of Cellular Aging. Aging Clin Exp Res. 2020;32(3):459-464. PubMed PMID: 31054115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E and Alzheimer's disease: the mediating role of cellular aging. AU - Casati,Martina, AU - Boccardi,Virginia, AU - Ferri,Evelyn, AU - Bertagnoli,Laura, AU - Bastiani,Patrizia, AU - Ciccone,Simona, AU - Mansi,Marta, AU - Scamosci,Michela, AU - Rossi,Paolo Dionigi, AU - Mecocci,Patrizia, AU - Arosio,Beatrice, Y1 - 2019/05/03/ PY - 2019/02/11/received PY - 2019/04/19/accepted PY - 2019/5/6/pubmed PY - 2020/6/13/medline PY - 2019/5/5/entrez KW - Alzheimer’s disease KW - Nitrosative stress KW - Oxidative stress KW - Telomere length KW - Vitamin E SP - 459 EP - 464 JF - Aging clinical and experimental research JO - Aging Clin Exp Res VL - 32 IS - 3 N2 - BACKGROUND: Vitamin E represents a potent antioxidant and anti-inflammatory system, playing a role in Alzheimer's disease (AD). Different plasma concentrations of the forms of vitamin E are observed in AD compared to cognitively healthy subjects. AIM: Since these modifications may modulate the markers of oxidative stress and cellular aging, we aim to explore the relationship between vitamin E forms and leukocyte telomere length (LTL) in AD. METHODS: 53 AD subjects and 40 cognitively healthy controls (CTs) were enrolled. The vitamin E forms (α-, β-, γ- and δ-tocopherol, α-, β-, γ- and δ-tocotrienol), the ratio of α-tocopherylquinone/α-tocopherol and 5-nitro-γ-tocopherol/γ-tocopherol (markers of oxidative/nitrosative damage) and LTL were measured. RESULTS AND DISCUSSION: Regression model was used to explore the associations of vitamin E forms and LTL with AD. The interaction of LTL in the association between vitamin E forms and AD was tested. AD subjects showed significantly lower concentrations of α-, β-, γ- and δ-tocopherol, α- and δ-tocotrienol, total tocopherols, total tocotrienols and total vitamin E compared to CTs. AD subjects showed higher values of nitrosative/oxidative damage. The adjusted analyses confirmed a significant relationship of AD with plasma concentrations of α- and β-tocopherols, δ-tocotrienol, total tocopherols, total tocotrienol, total vitamin E and oxidative/nitrosative damage. However, nitrosative damage was significantly associated with AD only in subjects with higher LTL and not in those expressing marked cellular aging. CONCLUSIONS: Our study confirms the role of vitamin E in AD pathology and indicates that nitrosative damage influences the association with AD only in subjects characterized by longer LTL. SN - 1720-8319 UR - https://www.unboundmedicine.com/medline/citation/31054115/Vitamin_E_and_Alzheimer's_disease:_the_mediating_role_of_cellular_aging_ DB - PRIME DP - Unbound Medicine ER -