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Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C).
Int J Cancer. 2020 02 15; 146(4):943-952.IJ

Abstract

Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case-control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97-10.68; insecticides HR = 2.86, 95% CI = 0.99-8.23; animals HR = 3.89, 95% CI = 1.18-12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12-5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31-0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.

Authors+Show Affiliations

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD. Washington State Department of Health, Office of Community Health Systems, Olympia, WA.Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands.International Agency for Research on Cancer, Lyon, France.Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands.Population Health, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia.Department of Hematology and Braun School of Public Health and Community Medicine, Hadassah-Hebrew University, Jerusalem, Israel.Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.Norwegian Institute of Public Health, Oslo, Norway. Department of Global Public Health and Community Care, University of Bergen, Bergen, Norway.Norwegian Institute of Public Health, Oslo, Norway.Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.Population Health, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia. Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia.College of Public Health, Ohio State University, Columbus, OH.Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.Norwegian Institute of Public Health, Oslo, Norway.Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark. Department of Public Health and Epidemiology, School of Public Health, University of California, Los Angeles, CA.Department of Epidemiology Research, Center for Fetal Programming, Staten Serum Institute, Copenhagen, Denmark.Population Health, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia. Nuffield Department of Obstetrics & Gynaecology, George Institute for Global Health, University of Oxford, Oxford, United Kingdom.Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL.Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31054169

Citation

Patel, Deven M., et al. "Parental Occupational Exposure to Pesticides, Animals and Organic Dust and Risk of Childhood Leukemia and Central Nervous System Tumors: Findings From the International Childhood Cancer Cohort Consortium (I4C)." International Journal of Cancer, vol. 146, no. 4, 2020, pp. 943-952.
Patel DM, Jones RR, Booth BJ, et al. Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). Int J Cancer. 2020;146(4):943-952.
Patel, D. M., Jones, R. R., Booth, B. J., Olsson, A. C., Kromhout, H., Straif, K., Vermeulen, R., Tikellis, G., Paltiel, O., Golding, J., Northstone, K., Stoltenberg, C., Håberg, S. E., Schüz, J., Friesen, M. C., Ponsonby, A. L., Lemeshow, S., Linet, M. S., Magnus, P., ... Ward, M. H. (2020). Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). International Journal of Cancer, 146(4), 943-952. https://doi.org/10.1002/ijc.32388
Patel DM, et al. Parental Occupational Exposure to Pesticides, Animals and Organic Dust and Risk of Childhood Leukemia and Central Nervous System Tumors: Findings From the International Childhood Cancer Cohort Consortium (I4C). Int J Cancer. 2020 02 15;146(4):943-952. PubMed PMID: 31054169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). AU - Patel,Deven M, AU - Jones,Rena R, AU - Booth,Benjamin J, AU - Olsson,Ann C, AU - Kromhout,Hans, AU - Straif,Kurt, AU - Vermeulen,Roel, AU - Tikellis,Gabriella, AU - Paltiel,Ora, AU - Golding,Jean, AU - Northstone,Kate, AU - Stoltenberg,Camilla, AU - Håberg,Siri E, AU - Schüz,Joachim, AU - Friesen,Melissa C, AU - Ponsonby,Anne-Louise, AU - Lemeshow,Stanley, AU - Linet,Martha S, AU - Magnus,Per, AU - Olsen,Jørn, AU - Olsen,Sjurdur F, AU - Dwyer,Terence, AU - Stayner,Leslie T, AU - Ward,Mary H, AU - ,, Y1 - 2019/05/24/ PY - 2019/02/06/received PY - 2019/03/14/revised PY - 2019/04/05/accepted PY - 2019/5/6/pubmed PY - 2020/4/3/medline PY - 2019/5/5/entrez KW - agricultural exposures KW - animals KW - childhood brain tumors KW - childhood cancer KW - childhood leukemia KW - organic dust KW - parental occupation KW - pesticides SP - 943 EP - 952 JF - International journal of cancer JO - Int J Cancer VL - 146 IS - 4 N2 - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case-control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97-10.68; insecticides HR = 2.86, 95% CI = 0.99-8.23; animals HR = 3.89, 95% CI = 1.18-12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12-5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31-0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/31054169/Parental_occupational_exposure_to_pesticides_animals_and_organic_dust_and_risk_of_childhood_leukemia_and_central_nervous_system_tumors:_Findings_from_the_International_Childhood_Cancer_Cohort_Consortium__I4C__ L2 - https://doi.org/10.1002/ijc.32388 DB - PRIME DP - Unbound Medicine ER -