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Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose.
J Pharm Sci. 2019 09; 108(9):3011-3019.JP

Abstract

Particle rearrangement takes place during the initial phase of tablet compaction. In this study, rough lactose particles were prepared by roller compaction, and their surface roughness modified by partial surface dissolution using a fluidized bed processor. Flow characteristics of the particles were determined using various flow methods, and their compaction characteristics studied using a compaction simulator with punches of different geometry and compaction pressure. Rougher particles demonstrated poorer compressibility and powder flow due to the higher interparticulate frictional forces required for particle movement. Rearrangement energy during tablet compaction was found to be correlated with compressibility (R2 = 0.92) and increased with surface roughness of the particles. Particle rearrangement was found to be dependent on interparticulate frictional forces, which could be measured using FT4 powder rheometer variable flow rate test and compressibility test. Plastic energy decreased as a result of the increased rearrangement energy requirements. Decrease in tensile strength as a result of decrease in plastic energy was not significantly different. Roller-compacted lactose particles produced tablets of higher tensile strength than crystalline lactose because of prefragmentation of the crystalline structure during roller compaction.

Authors+Show Affiliations

GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore. Electronic address: phapaulh@nus.edu.sg.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31054886

Citation

Tay, Justin Yong Soon, et al. "Effects of Particle Surface Roughness On In-Die Flow and Tableting Behavior of Lactose." Journal of Pharmaceutical Sciences, vol. 108, no. 9, 2019, pp. 3011-3019.
Tay JYS, Kok BWT, Liew CV, et al. Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose. J Pharm Sci. 2019;108(9):3011-3019.
Tay, J. Y. S., Kok, B. W. T., Liew, C. V., & Heng, P. W. S. (2019). Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose. Journal of Pharmaceutical Sciences, 108(9), 3011-3019. https://doi.org/10.1016/j.xphs.2019.04.028
Tay JYS, et al. Effects of Particle Surface Roughness On In-Die Flow and Tableting Behavior of Lactose. J Pharm Sci. 2019;108(9):3011-3019. PubMed PMID: 31054886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose. AU - Tay,Justin Yong Soon, AU - Kok,Berlinda Wen Ting, AU - Liew,Celine Valeria, AU - Heng,Paul Wan Sia, Y1 - 2019/05/02/ PY - 2019/03/10/received PY - 2019/04/11/revised PY - 2019/04/23/accepted PY - 2019/5/6/pubmed PY - 2020/8/22/medline PY - 2019/5/6/entrez KW - compaction KW - compression KW - fluid bed KW - image analysis KW - powder technology KW - solid dosage form SP - 3011 EP - 3019 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 108 IS - 9 N2 - Particle rearrangement takes place during the initial phase of tablet compaction. In this study, rough lactose particles were prepared by roller compaction, and their surface roughness modified by partial surface dissolution using a fluidized bed processor. Flow characteristics of the particles were determined using various flow methods, and their compaction characteristics studied using a compaction simulator with punches of different geometry and compaction pressure. Rougher particles demonstrated poorer compressibility and powder flow due to the higher interparticulate frictional forces required for particle movement. Rearrangement energy during tablet compaction was found to be correlated with compressibility (R2 = 0.92) and increased with surface roughness of the particles. Particle rearrangement was found to be dependent on interparticulate frictional forces, which could be measured using FT4 powder rheometer variable flow rate test and compressibility test. Plastic energy decreased as a result of the increased rearrangement energy requirements. Decrease in tensile strength as a result of decrease in plastic energy was not significantly different. Roller-compacted lactose particles produced tablets of higher tensile strength than crystalline lactose because of prefragmentation of the crystalline structure during roller compaction. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/31054886/Effects_of_Particle_Surface_Roughness_on_In_Die_Flow_and_Tableting_Behavior_of_Lactose_ DB - PRIME DP - Unbound Medicine ER -