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Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review.
Cent Nerv Syst Agents Med Chem. 2019; 19(2):75-99.CN

Abstract

INTRODUCTION

Neurodegenerative diseases (NDDs) are progressive, directly affecting the central nervous system (CNS), the most common and recurrent are Alzheimer's disease (AD) and Parkinson's disease (PD). One factor frequently mentioned in the etiology of NDDs is the generation of free radicals and oxidative stress, producing cellular damages. Studies have shown that the consumption of foods rich in polyphenols, especially those of the flavonoid class, has been related to the low risk in the development of several diseases. Due to the antioxidant properties present in the food, a fruit that has been gaining prominence among these foods is the Euterpe oleracea Mart. (açaí), because it presents in its composition significant amounts of a subclass of the flavonoids, the anthocyanins.

METHODS

In the case review, the authors receive a basic background on the most common NDDs, oxidative stress and antioxidants. In addition, revisiting the various studies related to NDDs, including flavonoids and consumption of açaí.

RESULTS

Detailed analysis of the recently reported case studies reveal that dietary consumption of flavonoid-rich foods, such as açaí fruits, suggests the efficacy to attenuate neurodegeneration and prevent or reverse the age-dependent deterioration of cognitive function.

CONCLUSION

This systematic review points out that flavonoids presenting in açaí have the potential for the treatment of diseases such as PD and AD and are candidates for drugs in future clinical research. However, there is a need for in vitro and in vivo studies with polyphenol that prove and ratify the therapeutic potential of this fruit for several NDDs.

Authors+Show Affiliations

Laboratory of Pharmaceutical and Medicinal Chemistry (PharMedChem), Federal University of Amapa, Macapa, Brazil.Laboratory of Pharmaceutical and Medicinal Chemistry (PharMedChem), Federal University of Amapa, Macapa, Brazil.Laboratory of Pharmaceutical and Medicinal Chemistry (PharMedChem), Federal University of Amapa, Macapa, Brazil.Computational Laboratory of Pharmaceutical Chemistry, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.Computational Laboratory of Pharmaceutical Chemistry, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.Computational Laboratory of Pharmaceutical Chemistry, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil. Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain, Instituto de Investigación, Biosanitaria ibs, Granada, Universidad de Granada, Granada, Spain.Laboratory of Phytopharmaceutical Nanobiotechnology, Federal University of Amapa, Macapa, Brazil.Laboratory of Pharmaceutical and Medicinal Chemistry (PharMedChem), Federal University of Amapa, Macapa, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31057125

Citation

de Oliveira, Nayana Keyla Seabra, et al. "Antioxidant Effect of Flavonoids Present in Euterpe Oleracea Martius and Neurodegenerative Diseases: a Literature Review." Central Nervous System Agents in Medicinal Chemistry, vol. 19, no. 2, 2019, pp. 75-99.
de Oliveira NKS, Almeida MRS, Pontes FMM, et al. Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review. Cent Nerv Syst Agents Med Chem. 2019;19(2):75-99.
de Oliveira, N. K. S., Almeida, M. R. S., Pontes, F. M. M., Barcelos, M. P., de Paula da Silva, C. H. T., Rosa, J. M. C., Cruz, R. A. S., & da Silva Hage-Melim, L. I. (2019). Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review. Central Nervous System Agents in Medicinal Chemistry, 19(2), 75-99. https://doi.org/10.2174/1871524919666190502105855
de Oliveira NKS, et al. Antioxidant Effect of Flavonoids Present in Euterpe Oleracea Martius and Neurodegenerative Diseases: a Literature Review. Cent Nerv Syst Agents Med Chem. 2019;19(2):75-99. PubMed PMID: 31057125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review. AU - de Oliveira,Nayana Keyla Seabra, AU - Almeida,Marcos Rafael Silva, AU - Pontes,Franco Márcio Maciel, AU - Barcelos,Mariana Pegrucci, AU - de Paula da Silva,Carlos Henrique Tomich, AU - Rosa,Joaquín María Campos, AU - Cruz,Rodrigo Alves Soares, AU - da Silva Hage-Melim,Lorane Izabel, PY - 2019/02/11/received PY - 2019/04/05/revised PY - 2019/04/11/accepted PY - 2019/5/7/pubmed PY - 2020/1/31/medline PY - 2019/5/7/entrez KW - Açaí KW - alzheimer's disease KW - antioxidant KW - flavonoids KW - neurodegenerative diseases KW - oxidative stress. SP - 75 EP - 99 JF - Central nervous system agents in medicinal chemistry JO - Cent Nerv Syst Agents Med Chem VL - 19 IS - 2 N2 - INTRODUCTION: Neurodegenerative diseases (NDDs) are progressive, directly affecting the central nervous system (CNS), the most common and recurrent are Alzheimer's disease (AD) and Parkinson's disease (PD). One factor frequently mentioned in the etiology of NDDs is the generation of free radicals and oxidative stress, producing cellular damages. Studies have shown that the consumption of foods rich in polyphenols, especially those of the flavonoid class, has been related to the low risk in the development of several diseases. Due to the antioxidant properties present in the food, a fruit that has been gaining prominence among these foods is the Euterpe oleracea Mart. (açaí), because it presents in its composition significant amounts of a subclass of the flavonoids, the anthocyanins. METHODS: In the case review, the authors receive a basic background on the most common NDDs, oxidative stress and antioxidants. In addition, revisiting the various studies related to NDDs, including flavonoids and consumption of açaí. RESULTS: Detailed analysis of the recently reported case studies reveal that dietary consumption of flavonoid-rich foods, such as açaí fruits, suggests the efficacy to attenuate neurodegeneration and prevent or reverse the age-dependent deterioration of cognitive function. CONCLUSION: This systematic review points out that flavonoids presenting in açaí have the potential for the treatment of diseases such as PD and AD and are candidates for drugs in future clinical research. However, there is a need for in vitro and in vivo studies with polyphenol that prove and ratify the therapeutic potential of this fruit for several NDDs. SN - 1875-6166 UR - https://www.unboundmedicine.com/medline/citation/31057125/Antioxidant_Effect_of_Flavonoids_Present_in_Euterpe_oleracea_Martius_and_Neurodegenerative_Diseases:_A_Literature_Review_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1871-5249&volume=19&issue=2&spage=75&aulast=de Oliveira DB - PRIME DP - Unbound Medicine ER -