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Adverse pregnancy outcomes and long-term risk of maternal renal disease: a systematic review and meta-analysis protocol.
BMJ Open. 2019 05 05; 9(5):e027180.BO

Abstract

INTRODUCTION

Adverse pregnancy outcomes, such as hypertensive disorders of pregnancy (HDP), gestational diabetes (GDM) and preterm birth have been linked to maternal cardiovascular disease in later life. Pre-eclampsia (PE) is associated with an increased risk of postpartum microalbuminuria, but there is no clear consensus on whether HDP increases the risk of maternal chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Similarly, it is uncertain whether GDM, preterm birth and delivery of low birth-weight infants independently predict the risk of maternal renal disease in later life. The aims of this proposed systematic review and meta-analysis are to summarise the available evidence examining the association between adverse outcomes of pregnancy (HDP, GDM, preterm birth, delivery of low birth-weight infant) and later maternal renal disease and to synthesise the results of relevant studies.

METHODS AND ANALYSIS

A systematic search of PubMed, EMBASE and Web of Science will be undertaken using a detailed prespecified search strategy. Two authors will independently review the titles and abstracts of all studies, perform data extraction and appraise the quality of included studies using a bias classification tool. Original case-control and cohort studies published in English will be considered for inclusion. Primary outcomes of interest will be CKD and ESKD; secondary outcomes will be hospitalisation for renal disease and deaths from renal disease. Meta-analyses will be performed to calculate the overall pooled estimates using the generic inverse variance method. The systematic review will follow the Meta-analyses Of Observational Studies in Epidemiology guidelines.

ETHICS AND DISSEMINATION

This systematic review and meta-analysis will be based on published data, and thus there is no requirement for ethics approval. The results will be shared through publication in a peer reviewed journal and through presentations at academic conferences.

PROSPERO REGISTRATION NUMBER

CRD42018110891.

Links

PMC Free PDF

Authors+Show Affiliations

Barrett PM
School of Public Health, University College Cork, Cork, Ireland. Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland.
McCarthy FP
Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland.
Kublickiene K
Department of Clinical Sciences Intervention and Technology, Karolinska Institutet, Huddinge, Sweden.
Evans M
Department of Clinical Sciences Intervention and Technology, Karolinska Institutet, Huddinge, Sweden.
Cormican S
Department of Nephrology, Galway University Hospital, Galway, Ireland.
Judge C
Department of Nephrology, Galway University Hospital, Galway, Ireland.
Perry IJ
School of Public Health, University College Cork, Cork, Ireland.
Kublickas M
Department of Clinical Sciences Intervention and Technology, Karolinska Institutet, Huddinge, Sweden. Department of Obstetrics & Gynaecology, Karolinska Institutet, Stockholm, Sweden.
Stenvinkel P
Department of Clinical Sciences Intervention and Technology, Karolinska Institutet, Huddinge, Sweden.
Khashan AS
School of Public Health, University College Cork, Cork, Ireland. Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland.

MeSH

FemaleHumansKidney DiseasesKidney Failure, ChronicMeta-Analysis as TopicPregnancyPregnancy ComplicationsPregnancy OutcomeRenal Insufficiency, ChronicResearch DesignRisk AssessmentSystematic Reviews as TopicTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31061049

Citation

Barrett, Peter M., et al. "Adverse Pregnancy Outcomes and Long-term Risk of Maternal Renal Disease: a Systematic Review and Meta-analysis Protocol." BMJ Open, vol. 9, no. 5, 2019, pp. e027180.
Barrett PM, McCarthy FP, Kublickiene K, et al. Adverse pregnancy outcomes and long-term risk of maternal renal disease: a systematic review and meta-analysis protocol. BMJ Open. 2019;9(5):e027180.
Barrett, P. M., McCarthy, F. P., Kublickiene, K., Evans, M., Cormican, S., Judge, C., Perry, I. J., Kublickas, M., Stenvinkel, P., & Khashan, A. S. (2019). Adverse pregnancy outcomes and long-term risk of maternal renal disease: a systematic review and meta-analysis protocol. BMJ Open, 9(5), e027180. https://doi.org/10.1136/bmjopen-2018-027180
Barrett PM, et al. Adverse Pregnancy Outcomes and Long-term Risk of Maternal Renal Disease: a Systematic Review and Meta-analysis Protocol. BMJ Open. 2019 05 5;9(5):e027180. PubMed PMID: 31061049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adverse pregnancy outcomes and long-term risk of maternal renal disease: a systematic review and meta-analysis protocol. AU - Barrett,Peter M, AU - McCarthy,Fergus P, AU - Kublickiene,Karolina, AU - Evans,Marie, AU - Cormican,Sarah, AU - Judge,Conor, AU - Perry,Ivan J, AU - Kublickas,Marius, AU - Stenvinkel,Peter, AU - Khashan,Ali S, Y1 - 2019/05/05/ PY - 2019/5/8/entrez PY - 2019/5/8/pubmed PY - 2020/6/4/medline KW - chronic renal failure KW - diabetes in pregnancy KW - end stage renal failure KW - epidemiology KW - obstetrics SP - e027180 EP - e027180 JF - BMJ open JO - BMJ Open VL - 9 IS - 5 N2 - INTRODUCTION: Adverse pregnancy outcomes, such as hypertensive disorders of pregnancy (HDP), gestational diabetes (GDM) and preterm birth have been linked to maternal cardiovascular disease in later life. Pre-eclampsia (PE) is associated with an increased risk of postpartum microalbuminuria, but there is no clear consensus on whether HDP increases the risk of maternal chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Similarly, it is uncertain whether GDM, preterm birth and delivery of low birth-weight infants independently predict the risk of maternal renal disease in later life. The aims of this proposed systematic review and meta-analysis are to summarise the available evidence examining the association between adverse outcomes of pregnancy (HDP, GDM, preterm birth, delivery of low birth-weight infant) and later maternal renal disease and to synthesise the results of relevant studies. METHODS AND ANALYSIS: A systematic search of PubMed, EMBASE and Web of Science will be undertaken using a detailed prespecified search strategy. Two authors will independently review the titles and abstracts of all studies, perform data extraction and appraise the quality of included studies using a bias classification tool. Original case-control and cohort studies published in English will be considered for inclusion. Primary outcomes of interest will be CKD and ESKD; secondary outcomes will be hospitalisation for renal disease and deaths from renal disease. Meta-analyses will be performed to calculate the overall pooled estimates using the generic inverse variance method. The systematic review will follow the Meta-analyses Of Observational Studies in Epidemiology guidelines. ETHICS AND DISSEMINATION: This systematic review and meta-analysis will be based on published data, and thus there is no requirement for ethics approval. The results will be shared through publication in a peer reviewed journal and through presentations at academic conferences. PROSPERO REGISTRATION NUMBER: CRD42018110891. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/31061049/Adverse_pregnancy_outcomes_and_long_term_risk_of_maternal_renal_disease:_a_systematic_review_and_meta_analysis_protocol_ DB - PRIME DP - Unbound Medicine ER -