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Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002-2015): 244 cases.

Abstract

OBJECTIVE

To evaluate changes in serum creatinine and chloride concentrations in anesthetized dogs that received 6% hydroxyethyl starch (HES) 670/0.7.

DESIGN

Retrospective case series, 2002-2015.

SETTING

University veterinary teaching hospital.

ANIMALS

Two hundred forty-four client-owned dogs undergoing general anesthesia that received an HES solution.

INTERVENTIONS

None.

MEASUREMENTS AND MAIN RESULTS

Medical records of dogs that received an HES solution (6%, 670/0.7) while under general anesthesia during the study period were reviewed. Information obtained from the medical record included patient signalment, reason for anesthesia or diagnosis, body weight, amount of HES solution administered, pre- and postanesthesia creatinine value, pre- and postanesthesia chloride value, and day interval between measurements. Corrected chloride values were used for all statistical analysis. Dogs received a median dose of 6.3 mL/kg hetastarch during anesthesia. Median preanesthesia creatinine and corrected chloride values were 79.5 μmol/L (0.9 mg/dL) (range 8.8-689.5 μmol/L [0.1-7.8 mg/dL]) and 111 mmol/L (111 mEq/L) (range 80-123 mmol/L [80-123 mg/dL]), respectively. Median postanesthesia creatinine was 57.4 μmol/L (0.65 mg/dL) (8.8-716 μmol/L [0.1-8.1 mg/dL]). Median postanesthesia corrected chloride was 115 mmol/L (115 mEq/L) (range 87.5-129.6 mmol/L [87.5-129.6 mEq/L]). Mann-Whitney test analysis revealed a significant decrease in creatinine (Δ Cr 17.7 μmol/L [0.2 mg/dL], P < 0.01) and a significant increase in corrected chloride (Δ Cl 4.1 mmol/L [4.1mEq/L], P < 0.01) between pre- and postanesthesia values.

CONCLUSIONS

In a mixed population of hospitalized dogs undergoing general anesthesia that received a median dose of 6 mL/kg of HES, creatinine was lower and chloride was higher in the postanesthetic than in the preanesthetic period. The clinical significance of these changes and the role that HES administration played in them relative to concurrent therapies is unknown.

Authors+Show Affiliations

Department of Clinical Sciences, Colorado State University, Fort Collins, CO.Department of Clinical Sciences, Colorado State University, Fort Collins, CO.Department of Clinical Sciences, Colorado State University, Fort Collins, CO.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31066159

Citation

Zersen, Kristin M., et al. "Retrospective Evaluation of Paired Plasma Creatinine and Chloride Concentrations Following Hetastarch Administration in Anesthetized Dogs (2002-2015): 244 Cases." Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), vol. 29, no. 3, 2019, pp. 309-313.
Zersen KM, Mama K, Mathis JC. Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002-2015): 244 cases. J Vet Emerg Crit Care (San Antonio). 2019;29(3):309-313.
Zersen, K. M., Mama, K., & Mathis, J. C. (2019). Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002-2015): 244 cases. Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), 29(3), pp. 309-313. doi:10.1111/vec.12836.
Zersen KM, Mama K, Mathis JC. Retrospective Evaluation of Paired Plasma Creatinine and Chloride Concentrations Following Hetastarch Administration in Anesthetized Dogs (2002-2015): 244 Cases. J Vet Emerg Crit Care (San Antonio). 2019;29(3):309-313. PubMed PMID: 31066159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002-2015): 244 cases. AU - Zersen,Kristin M, AU - Mama,Khursheed, AU - Mathis,Justin C, Y1 - 2019/05/08/ PY - 2016/10/03/received PY - 2017/06/13/revised PY - 2017/06/21/accepted PY - 2019/5/9/pubmed PY - 2019/7/16/medline PY - 2019/5/9/entrez KW - anesthesia KW - colloids KW - electrolytes KW - kidney function SP - 309 EP - 313 JF - Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) JO - J Vet Emerg Crit Care (San Antonio) VL - 29 IS - 3 N2 - OBJECTIVE: To evaluate changes in serum creatinine and chloride concentrations in anesthetized dogs that received 6% hydroxyethyl starch (HES) 670/0.7. DESIGN: Retrospective case series, 2002-2015. SETTING: University veterinary teaching hospital. ANIMALS: Two hundred forty-four client-owned dogs undergoing general anesthesia that received an HES solution. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Medical records of dogs that received an HES solution (6%, 670/0.7) while under general anesthesia during the study period were reviewed. Information obtained from the medical record included patient signalment, reason for anesthesia or diagnosis, body weight, amount of HES solution administered, pre- and postanesthesia creatinine value, pre- and postanesthesia chloride value, and day interval between measurements. Corrected chloride values were used for all statistical analysis. Dogs received a median dose of 6.3 mL/kg hetastarch during anesthesia. Median preanesthesia creatinine and corrected chloride values were 79.5 μmol/L (0.9 mg/dL) (range 8.8-689.5 μmol/L [0.1-7.8 mg/dL]) and 111 mmol/L (111 mEq/L) (range 80-123 mmol/L [80-123 mg/dL]), respectively. Median postanesthesia creatinine was 57.4 μmol/L (0.65 mg/dL) (8.8-716 μmol/L [0.1-8.1 mg/dL]). Median postanesthesia corrected chloride was 115 mmol/L (115 mEq/L) (range 87.5-129.6 mmol/L [87.5-129.6 mEq/L]). Mann-Whitney test analysis revealed a significant decrease in creatinine (Δ Cr 17.7 μmol/L [0.2 mg/dL], P < 0.01) and a significant increase in corrected chloride (Δ Cl 4.1 mmol/L [4.1mEq/L], P < 0.01) between pre- and postanesthesia values. CONCLUSIONS: In a mixed population of hospitalized dogs undergoing general anesthesia that received a median dose of 6 mL/kg of HES, creatinine was lower and chloride was higher in the postanesthetic than in the preanesthetic period. The clinical significance of these changes and the role that HES administration played in them relative to concurrent therapies is unknown. SN - 1476-4431 UR - https://www.unboundmedicine.com/medline/citation/31066159/Retrospective_evaluation_of_paired_plasma_creatinine_and_chloride_concentrations_following_hetastarch_administration_in_anesthetized_dogs_(2002-2015):_244_cases L2 - https://doi.org/10.1111/vec.12836 DB - PRIME DP - Unbound Medicine ER -