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Effects of Opium Addiction on Some Biochemical Factors in Diabetic Rats.
Addict Health. 2018 Apr; 10(2):123-130.AH

Abstract

BACKGROUND

The present study was carried out aiming to investigate the effects of opium on some biochemical factors in diabetic and non-diabetic male and female rats.

METHODS

This experimental study was carried out on 28 male and 28 female Wistar rats. The animals were divided into diabetic addicted (DA), diabetic non-addicted (DNA), non-diabetic addicted (NDA), and non-diabetic non-addicted (NDNA) groups of male and female. A double dose of opium was intraperitoneally administered to the addicted groups. Peripheral blood samples were collected to measure the creatinine, uric acid, cholesterol, triglycerides (TG), total protein, and albumin levels. Three-way analysis of variance (ANOVA) was used to compare the mean levels of biofactors among the study groups.

FINDINGS

Cholesterol and total protein were significantly affected by opium and sex, but not diabetes condition, such that there was a decrease of cholesterol and total protein levels in opium-addicted rats compared to non-opium-addicted ones. However, uric acid, TG, albumin, and creatinine were not affected by opium and diabetes conditions.

CONCLUSION

Opium significantly decreased cholesterol and total protein levels. It could be deduced that the effects of opium on cholesterol and total protein are not sex-dependent, moreover, opium consumption may not have significant effects on biochemical factors in diabetic conditions.

Authors+Show Affiliations

Professor, Neuroscience Research Center, Institute of Neuropharmacology AND Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.PhD Candidate, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Biochemist, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.Dentist, Student Research Committee, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.PhD Candidate, Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah AND Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.PhD, Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University AND Sarem Fertility and Infertility Research Center AND Sarem Cell Research Center, Sarem Women's Hospital, Tehran, Iran.Associate Professor, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31069036

Citation

Asadikaram, Gholamreza, et al. "Effects of Opium Addiction On some Biochemical Factors in Diabetic Rats." Addiction & Health, vol. 10, no. 2, 2018, pp. 123-130.
Asadikaram G, Vakili S, Akbari H, et al. Effects of Opium Addiction on Some Biochemical Factors in Diabetic Rats. Addict Health. 2018;10(2):123-130.
Asadikaram, G., Vakili, S., Akbari, H., Kheirmand-Parizi, M., Sadeghi, E., Asiabanha, M., & Shahrokhi, N. (2018). Effects of Opium Addiction on Some Biochemical Factors in Diabetic Rats. Addiction & Health, 10(2), 123-130. https://doi.org/10.22122/ahj.v10i2.531
Asadikaram G, et al. Effects of Opium Addiction On some Biochemical Factors in Diabetic Rats. Addict Health. 2018;10(2):123-130. PubMed PMID: 31069036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Opium Addiction on Some Biochemical Factors in Diabetic Rats. AU - Asadikaram,Gholamreza, AU - Vakili,Sina, AU - Akbari,Hamed, AU - Kheirmand-Parizi,Marjan, AU - Sadeghi,Erfan, AU - Asiabanha,Majid, AU - Shahrokhi,Nader, PY - 2019/5/10/entrez PY - 2019/5/10/pubmed PY - 2019/5/10/medline KW - Biochemical markers KW - Cholesterol KW - Creatinine KW - Diabetes mellitus KW - Opium addiction KW - Total protein SP - 123 EP - 130 JF - Addiction & health JO - Addict Health VL - 10 IS - 2 N2 - BACKGROUND: The present study was carried out aiming to investigate the effects of opium on some biochemical factors in diabetic and non-diabetic male and female rats. METHODS: This experimental study was carried out on 28 male and 28 female Wistar rats. The animals were divided into diabetic addicted (DA), diabetic non-addicted (DNA), non-diabetic addicted (NDA), and non-diabetic non-addicted (NDNA) groups of male and female. A double dose of opium was intraperitoneally administered to the addicted groups. Peripheral blood samples were collected to measure the creatinine, uric acid, cholesterol, triglycerides (TG), total protein, and albumin levels. Three-way analysis of variance (ANOVA) was used to compare the mean levels of biofactors among the study groups. FINDINGS: Cholesterol and total protein were significantly affected by opium and sex, but not diabetes condition, such that there was a decrease of cholesterol and total protein levels in opium-addicted rats compared to non-opium-addicted ones. However, uric acid, TG, albumin, and creatinine were not affected by opium and diabetes conditions. CONCLUSION: Opium significantly decreased cholesterol and total protein levels. It could be deduced that the effects of opium on cholesterol and total protein are not sex-dependent, moreover, opium consumption may not have significant effects on biochemical factors in diabetic conditions. SN - 2008-4633 UR - https://www.unboundmedicine.com/medline/citation/31069036/Effects_of_Opium_Addiction_on_Some_Biochemical_Factors_in_Diabetic_Rats_ DB - PRIME DP - Unbound Medicine ER -
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